A Case of Neonatal Lupus Erythematosus Presenting Delayed Dilated Cardiomyopathy With Circulating Autoantibody to Annexin A6

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概要

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• Patients with neonatal lupus erythematosus (NLE) often have congenital heart block with or without heart failure and are born to mothers who have anti-SS-A and/or anti-SS-B antibodies. NLE has been considered to result from the placental transmission of maternal autoantibodies into the fetal circulation causing myocardial damage. We report a case of NLE with congenital heart block who had undergone pacemaker implantation at the age of 17, and then developed dilated cardiomyopathy (DCM) at the age of 19, which is much later than in most other cases. The patients mother was positive for anti-SS-A and anti-SS-B antibodies, whereas the patient was negative for both anti-SS-A and anti-SS-B antibodies. There were some autoantibodies against cell surface antigens of cardiac myocytes in the serum from the patient, and annexin A6 was identified as one of the autoantigens. This is the first report demonstrating that annexin A6 is involved in the myocardial injury in patients with NLE. The results indicate that inhibition of annexin A6 function may prevent autoantibody-mediated myocardial injury in at least some cases of DCM.

• インターナショナル・ハート・ジャーナル刊行会の論文

著者

• NAGAI Ryozo

  Department of Cardiovascular Medicine, University of Tokyo

• Imai Yasushi

  Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo

• Hirata Yasunobu

  Department of Cardiovascular Medicine, The University of Tokyo

• Hirata Yasunobu

  Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo

• MATSUMOTO AKIHIRO

  Department of Urology, Graduate School of Medicine, Chiba University, and Chiba University Hospital

• Nagai Ryozo

  武蔵野赤十字病院

• Fukuda Taira

  Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo

• FUJIMURA Tsutomu

  Division of Biochemical Analysis, Central Laboratory of Medical Sciences

• MURAYAMA Kimie

  Division of Biochemical Analysis, Central Laboratory of Medical Sciences

• Seko Yoshinori

  Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo

• Taka Hikari

  Division of Proteomics and Biomolecular Science, BioMedical Research Center, Graduate School of Medi

• Mineki Reiko

  Division of Proteomics and Biomolecular Science, BioMedical Research Center, Graduate School of Medi

• Imai Yasushi

  Department Of Cardiovascular Medicine Graduate School Of Medicine The University Of Tokyo

• Seko Yoshinori

  東京大学 大学院医学研究科循環器内科

• Seko Yoshinori

  Department Of Cardiology Institute For Adult Diseases Asahi Life Foundation

• Murayama K

  Central Laboratory Of Medical Sciences Juntendo University School Of Medicine

• Taka Hikari

  Central Laboratory Of Medical Sciences Juntendo University School Of Medicine

• Taka Hikari

  Division Of Proteomics And Biomolecular Science Biomedical Research Center Graduate School Of Medici

• Mineki Reiko

  Division Of Biochemical Analysis Central Laboratory Of Medical Science Juntendo University School Of

• Fujimura Tsutomu

  Division Of Biochemical Analysis Central Laboratory Of Medical Sciences

• Murayama Kimie

  Division Of Biochemical Analysis Central Laboratory Of Medical Sciences

• Hirata Yasunobu

  Department Of Advanced Clinical Science And Therapeutics Cardiovascular Medicine Graduate School Of

• Matsumoto Akihiro

  Department Of Cardiothoracic Surgery The University Of Tokyo

• Nagai Ryozo

  Department Cardiovascular Medicine The University Of Tokyo Hospital

• Fukuda Taira

  Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo

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