Growth and Functional Behavior Neuroblastomas in Man and Nude Mice
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概要
- 論文の詳細を見る
Nine human neuroblastoma were serially transplanted in nude mice. These tumor lines were established from the patients older than 1 year 10 month year old. None of the tumors taken from under the age of 1 year and 7 months grew in nude mice. All transplanted tumors produced catecholamines in varying degree. The growth of low catecholamines producing tumors was apparently aggressive compared with high catecholamines producing tumor lines. These results may indicate that tumor aggressiveness decreases with increased functional differentiation in human neuroblastoma in nude mice. The contents of catecholamine was closely correlated with the number and size of secretory granules in tumor cells. This human neuroblastoma/nude mice system may prove to be a useful tool for basic research on the biological behavior as well as on the cytological and functional differentiation of human neurobalstoma.
- 東海大学の論文
- 1980-09-13
著者
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UEYAMA Yoshito
Department of Pathology, School of Medicine, Tokai University
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TAMAOKI Norikazu
Department of Pathology, School of Medicine, Tokai University
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Ueyama Y
Tokai Univ. School Of Medicine Kanagawa Jpn
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Ueyama Y
Tokai Univ. School Of Medicine Isehara‐shi Jpn
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HATA Jun-ichi
Department of Pathology, School of Medicine, Keio University
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Ueyama Yoshito
Department Of Pathology School Of Medicine Tokai University
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Hata Junichi
Department Of Pathology Keio University School Of Medicine
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Hata J
Keio Univ. School Of Medicine
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Hata Jun-ichi
Department Of Chemical Science And Engineering Graduate School Of Engineering Science Osaka Universi
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Tamaoki Norikazu
Department Of Pathology School Of Medicine Tokai University
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UEYAMA Yoshito
Department of Dermatology, Division of Specialized Clinical Science, Tokai University School of Medicine
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Hata Jun-ichi
Department of Chemical Engineering, Faculty of Engineering Science, Osaka University
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