A Novel Imprinted Gene, KCNQ1DN, within the WT2 Critical Region of Human Chromosome 11p15.5 and Its Reduced Expression in Wilms' Tumors.
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概要
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WT2 is defined by a maternal-specific loss of heterozygosity on human chromosome 11p15.5 in Wilms' and other embryonal tumors. Therefore, the imprinted genes in this region are candidates for involvement in Wilms' tumorigenesis. We now report a novel imprinted gene, KCNQ1DN (KCNQ1 downstream neighbor). This gene is located between p57KIP2 and KvLQT1 (KCNQ1) of 11p15.5 within the WT2 critical region. KCNQ1DN is imprinted and expressed from the maternal allele. We examined the expression of KCNQ1DN in Wilms' tumors. Seven of eighteen (39%) samples showed no expression. In contrast, other maternal imprinted genes in this region, including p57KIP2, IMPT1, and IPL exhibited almost normal expression in these samples, although some samples expressed IGF2 biallelically. These results suggest that KCNQ1DN existing far from the H19/IGF2 region may play some role in Wilms' tumorigenesis along with IGF2.
- 社団法人 日本生化学会の論文
著者
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HIGASHIMOTO Ken
Department of Biomolecular Sciences, Division of Molecular Biology and Genetics, Faculty of Medicine
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Kaneko Yasuhiko
Department Of Cancer Chemotherapy Saitama Cancer Center Hospital
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Zhu Xike
Department Of Biochemistry Saga Medical School
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MASAKI Zenjiro
Division of Urology Department of Surgery Saga Medical School
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Yatsuki Hitomi
Department Of Biochemistry Saga Medical School
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Jinno Yoshihiro
Department Of Human Genetics Nagasaki University School Of Medicine
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Fukuzawa Ryuji
Department Of Pathology Keio University School Of Medicine
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Xin Zhenghan
Department Of Biochemistry Saga Medical School
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Soejima Hidenobu
Department Of Biomolecular Sciences Faculty Of Medicine Saga University
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Hata Jun-ichi
Department of Chemical Engineering, Faculty of Engineering Science, Osaka University
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Mukai Tsunehiro
Department of Biochemistry and Department of Surgery, Saga Medical School
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Saton Yuji
Department of Biochemistry and Department of Surgery, Saga Medical School
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- A Novel Imprinted Gene, KCNQ1DN, within the WT2 Critical Region of Human Chromosome 11p15.5 and Its Reduced Expression in Wilms' Tumors.