Expression and Imprinting Status of Human PEG8/IGF2AS, a Patemally Expressed Antisense Transcript from the IGF2 Locus, in Wilms' Tumors.
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概要
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A large imprinted gene cluster in human chromosome 11p15.5 has been implicated in Beckwith-Wiedemann syndrome and Wilms' tumor. We have identified a paternally expressed imprinted gene, PEG8/IGF2AS, in this locus. It is transcribed in the opposite direction to the IGF2 transcripts and some genomic regions are shared with the IGF2 gene, as in the case of the mouse imprinted Igf2as gene reported previously by T. Moore et al. As to the relationship between these genomic regions, the human and mouse genes are very similar but there is no homology in their middle parts. Interestingly, PEG8/ IGF2AS and IGF2 were found to be overexpressed in Wilms' tumor samples, at levels over ten and a hundred times higher than that in normal kidney tissues neighboring the tumors, respectively. These findings indicate that PEG8/IGF2AS is a good marker of Wilms' tumor and also suggest the possibility of PEG8/IGF2AS being one of the candidate Wilms' tumor genes.
- 社団法人 日本生化学会の論文
著者
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Kai Masayuki
Gene Research Center Tokyo Institute Of Technology
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KOHDA Takashi
Gene Research Center, Tokyo Institute of Technology
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KANEKO-ISHINO Tomoko
CREST, Japan Science and Technology Corporation (JST)
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Ishino Fumitoshi
Gene Research Center Tokyo Institute Of Technology
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Kaneko Yasuhiko
Department Of Cancer Chemotherapy Saitama Cancer Center Hospital
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Aisaka Kohzo
Department Of Ob Gyn Odaira Memorial Tokyo Hitachi Hospital
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Kuroiwa Yoshimi
Gene Research Center Tokyo Institute Of Technology
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Okutsu Tomohisa
Gene Research Center Tokyo Institute Of Technology
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Kagitani Fusako
Gene Research Center Tokyo Institute Of Technology
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Tsutsumi Osamu
Department of Applied Chemistry for Resources, Tokyo University of Agriculture and Technology
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SURANI M.
Wellcome/CRC Institute of Cancer and Developmental Biology, Physiological Laboratory, University of Cambridge
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Yokomori Kinji
Gene Research Center, Tokyo Institute of Technology
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