DIOXINS IN BILE IN RELATION TO THOSE IN THE HUMAN LIVER AND BLOOD
スポンサーリンク
概要
- 論文の詳細を見る
The levels of 20 dioxin congeners, 7 polychlorinated dibenzo-p-dioxins(PCDDs), 10 polychlorinated dibenzofurans(PCDFs)and three coplanar polychlorinated biphenyls(Co-PCBs), in bile were examined in comparison with those in the blood and liver, in 27 autopsy cases. Total-TEQ values were the same in the bile(43.2±30.9 pg TEQ/g lipid)and blood(43.1±24.2 pg TEQ/g lipid), and three times higher in the liver(127.8±57.4 pg TEQ/g lipid). Highly chlorinated PCDDs and PCDFs have a tendency to accumulate in the liver, and their levels in bile and blood were relatively low compared with those in the liver, with 1, 2, 3, 4, 6, 7, 8-heptachlorodibenzofuran having the highest tendency among the 20 congeners. Daily excretion in bile was calculated to be 54 pg TEQ at age 65, by assuming that daily bile secretion is 750 ml and is concentrated 7.5-fold in the gallbladder. The correlation between bile and blood total-TEQ was high, with a correlation coefficient of 0.89 among the 27 autopsy cases. Thus, the regression equation of y = 1.14x - 6.02 will provide us levels in bile(total TEQ per g lipid), knowing the blood total-TEQ level, where x is total-TEQ per g lipid of the blood. Furthermore, accumulation of dioxins was estimated to be 0.99, 0.70 and 1.91 pg TEQ/g lipid/year in bile, blood and liver, respectively.
- 日本トキシコロジー学会の論文
- 2001-12-21
著者
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Nagao Minako
東京農業大学 応用生物科
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Nagao Minako
Laboratory Of Protection Of Body Function Faculty Of Applied Bioscience Tokyo University Of Agricult
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KITAMURA Kimiyoshi
Laboratory of Protection of Body Function, Faculty of Applied Bioscience, Tokyo University of Agricu
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YAMADA Taketo
Department of Pathology, School of Medicine, Keio University
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SUNAGA Masahiro
Laboratory of Public Health Nutrition and Epidemiology, Faculty of Applied Bioscience, Tokyo Univers
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HATA Jun-ichi
Department of Pathology, School of Medicine, Keio University
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WATANABE Shaw
Laboratory of Public Health Nutrition and Epidemiology, Faculty of Applied Bioscience, Tokyo Univers
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Nagao Minako
Department Of Nutritional Sciences Faculty Of Applied Biosciences Tokyo University Of Agriculture
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Yamada T
Otsuka Department Of Clinical And Molecular Nutrition Tokushima University School Of Medicine
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Hata J
Keio Univ. School Of Medicine Tokyo
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Hata Jun-ichi
Department Of Pathology And Department Of Pediatrics Keio University School Of Medicine
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Sunaga M
Safety Res. Inst. Chemical Compounds Co. Ltd. Hokkaido Jpn
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Hata Jun-ichi
Department Of Chemical Science And Engineering Graduate School Of Engineering Science Osaka Universi
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Yamada Taketo
Otsuka Department Of Clinical And Molecular Nutrition Tokushima University School Of Medicine
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Yamada Taketo
Department Of Microbiology And Immunology School Of Medicine Keio University
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Watanabe Shaw
Laboratory Of Public Health Nutrition And Epidemiology Faculty Of Applied Bioscience Tokyo Universit
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Yamaoka Takashi
Otsuka Department Of Clinical And Molecular Nutrition Tokushima University School Of Medicine
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Kitamura Kuniaki
National Printing Bureau
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Kitamura Kimiyoshi
Department Of Nutritional Sciences Faculty Of Applied Biosciences Tokyo University Of Agriculture:(p
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YAMADA Taketo
Department of Anesthesiology, School of Medicine, Keio University
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Hata Jun-ichi
Department of Chemical Engineering, Faculty of Engineering Science, Osaka University
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