Effects of Dioxins on Human Health : A Review
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概要
- 論文の詳細を見る
The toxicity of 2, 3, 7, 8-tetrachlorodibenzodioxin (TCDD) has been known since 1950s. TCDD is a by-product of herbicide 2, 4-dichloroacetophenol (2, 4-D) and 2, 4, 5-trichloroacetophenol (2, 4, 5- T), but it was first found in fryash of municipal incinerator in 1979 in Japan. In 1998, the survey of municipal incinerators revealed that 105 out of 1, 641 produced above the allowed emission level of 80 ng TEQ/m3. Total annual release of dioxins is estimated to be about 5, 000 g TEQ in 1997 in Japan. Japanese government started a comprehensive survey for dioxin levels in milk and blood of residents around incinerators, and their health effects. Human effects by dioxin exposures in Western countries were mostly acute and at high level in accidentally and/or occupationally. Health effects of low-dose and long lasting exposure has not been well understood.Certain amount of polychlorinated dibenzo-p-dioxins (PCDD), dibenzofurans (PCDF) and polychlorinated biphenyls (PCB) is accumulated in our body. Mothers milk is also contaminated by PCDD/PCDF. Health effects of the polychlorinated chemicals are summarized, and the necessity of regulations and recommendations for making a guideline is discussed in this review. J Epidemiol, 1999 citation=4. IARC. Monographs on the Evaluation of Carcinogenic Risks to Humans. Vol 69. Polychlorinated dibenzo-para- dioins and polychlorinated dibenzofurans. IARC, Lyon, 1998.; 9 : 1-13
著者
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Nagahashi Masahito
Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
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Watanabe Shaw
Department Of Nutrition Tokyo University Of Agriculture
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Watanabe Shaw
Laboratory Of Public Health Nutrition And Epidemiology Faculty Of Applied Bioscience Tokyo Universit
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Kitamura Kuniaki
National Printing Bureau
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Kitamura Kimiyoshi
Department Of Nutritional Sciences Faculty Of Applied Biosciences Tokyo University Of Agriculture:(p
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Kitamura Kimiyoshi
Department Of Applied Bioscience Tokyo University Of Agriculture
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Nagahashi Masahito
Department Of Nutritional Science Faculty Of Applied Bioscience Tokyo University Of Agriculture
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Watanabe Shaw
Department Of Agriculture Tokyo Agricultural University
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