Effects of Dietary Polyamines on the Promotion of Mammary Tumor in Rats

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概要

• 論文の詳細を見る

• The effects of dietary polyamines have been investigated on 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP)- induced carcinogenesis of the breast in rats by feeding spermidine (Spd) at three different concentrations. The cumulative incidence of mammary tumor in the group treated with PhIP plus Spd was 92% (low spermidine diet) and 68% (high spermidine diet), compared to 50% in the PhIP group with a control diet. These results suggest that dietary polyamines may enhance the promotion of PhIP- in- duced mammary carcinogenesis. In addition, however, a low spermidine diet can promote the development of tumor in rats, but on the other hand a high spermidine diet may suppress the mammary carcinogenesis.

• 公益社団法人日本薬学会の論文
• 2002-08-01

著者

• WADA Masahiro

  Faculty of Pharmaceutical Sciences, Josai University

• Udaka S

  Faculty Of Applied Bio-science Tokyo University Of Agriculture

• Udaka Shigezo

  Faculty Of Agriculture Nagoya University:department Of Brewing And Fermentation Tokyo University Of

• Funada-Wada Ulala

  Faculty of Pharmaceutical Sciences, Josai University

• Mano Hiroshi

  Faculty of Pharmaceutical Sciences, Josai University

• Higashiguchi Mizuka

  Faculty of Pharmaceutical Sciences, Josai University

• Haba Ryouta

  Faculty of Applied Bioscience, Tokyo University of Agriculture

• Watanabe Shew

  Faculty of Applied Bioscience, Tokyo University of Agriculture

• Watanabe Shaw

  Laboratory Of Public Health Nutrition And Epidemiology Faculty Of Applied Bioscience Tokyo Universit

• Udaka Shigezo

  Dept. Of Food Science And Technology Faculty Of Agriculture Nagoya University

• Wada Masahiro

  Faculty Of Pharmaceutical Science Josai University

• Mano Hiroshi

  Faculty Of Pharmaceutical Science Josai University

• WADA Masahiro

  Faculty of Education, Okayama University

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