Balance of Intake and Excretion of 20 Congeners of Polychlorinated Dibenzo-p-dioxin, Polychlorinated Dibenzofuran and Coplanar Polychlorinated Biphenyl in Healthy Japanese Men

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概要

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• Daily intake from meals, and excretion from feces and sebum of 20 congeners of polychlorinated dibenzo-p-dioxin (PCDD), polychlorinated dibenzofuran (PCDF) and coplanar polychlorinated biphenyl (Co-PCB) were analyzed in healthy Japanese men who are considered to be a standard for the Japanese. Daily intake of these congeners was 84.2±12.5 pg toxic equivalent (TEQ) and daily excretion from feces and sebum were 18.3±5.9 and 23.8±5.6 pg TEQ, respectively, indicating 22% the daily intake of dioxins from meals is excreted from feces and 29% from sebum. 1, 2, 3, 7, 8-Pentachlorodibenzo-p-dioxin (1, 2, 3, 7, 8-PeCDD), 2, 3, 4, 7, 8-pentachlorodibenzofuran (2, 3, 4, 7, 8-PeCDF) and 3, 3', 4, 4', 5-pentachlorobiphenyl (3, 3', 4, 4', 5-PeCB) were most abundant in TEQ, in meals, feces, sebum and blood. Co-PCBs were most efficiently excreted among three congener groups in TEQ, especially from sebum. Octachlorodibenzo-p-dioxin (OCDD), 2, 3, 7, 8-tetrachlorodibenzofuran (2, 3, 7, 8-TCDF) and 3, 3', 4, 4'-tetrachlorobiphenyl (3, 3', 4, 4'-TCB) were well absorbed from intestine and excreted at more than 100% of intake, mainly from the sebum. In contrast, 1, 2, 3, 4, 7, 8-hexachlorodibenzo-p-dioxin (1, 2, 3, 4, 7, 8-HxCDD) and 1, 2, 3, 7, 8, 9hexachlorodibenzofuran (1, 2, 3, 7, 8, 9-HxCDF) were excreted at relatively low levels from sebum, although well absorbed from the intestine, and the excretion ratios were lowest among the 20 congeners. It was suggested that 80.5-85.2% TEQ of each congener-group might be absorbed from the intestine, after taking bile excretion into consideration.

• 社団法人日本薬学会の論文
• 2001-04-01

著者

• WATANABE Shaw

  Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

• Nagao Minako

  東京農業大学 応用生物科

• Nagao Minako

  Laboratory Of Protection Of Body Function Faculty Of Applied Bioscience Tokyo University Of Agricult

• Kitamura Kimiyoshi

  Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

• Nagahashi Masahito

  Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

• Sunaga Masahiro

  Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

• Nagao Minako

  Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

• Nagao Minako

  Department Of Nutritional Sciences Faculty Of Applied Biosciences Tokyo University Of Agriculture

• Sunaga M

  Safety Res. Inst. Chemical Compounds Co. Ltd. Hokkaido Jpn

• Watanabe Shaw

  Department Of Nutrition Tokyo University Of Agriculture

• Watanabe Shaw

  Laboratory Of Public Health Nutrition And Epidemiology Faculty Of Applied Bioscience Tokyo Universit

• Kitamura Kuniaki

  National Printing Bureau

• Kitamura Kimiyoshi

  Department Of Nutritional Sciences Faculty Of Applied Biosciences Tokyo University Of Agriculture:(p

• Kitamura Kimiyoshi

  Department Of Applied Bioscience Tokyo University Of Agriculture

• Nagahashi Masahito

  Department Of Nutritional Science Faculty Of Applied Bioscience Tokyo University Of Agriculture

• Watanabe Shaw

  Department Of Agriculture Tokyo Agricultural University

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