COMPARATIVE TOXICITY STUDY OF 3-AMINOPHENOL IN NEWBORN AND YOUNG RATS
スポンサーリンク
概要
- 論文の詳細を見る
Repeated dose toxicity of 3-aminophenol was examined on oral administration to newborn and young rats, and susceptibility was analyzed in terms of the no observed adverse effect level (NOAEL) and the unequivocally toxic level. In the 18-day newborn rat study, starting at day 4 after birth, tremors and depression of body weight gain were observed, as well as hypertrophy of thyroid follicular epithelial cells and increases of relative liver and kidney weights at 240 mg/kg. Increase of relative liver weights in males and decrease of blood sugar in females without any histopathological changes at 80 mg/kg were not considered to be adverse effects. No chemical-related changes were observed at 24 mg/kg. Abnormalities of external development and reflex ontogeny in the newborn were not observed. In the 28-day study, starting at 5 weeks of age, depression of body weight gain, tremors, anemia, and liver, kidney and thyroid toxicity were observed at 720 mg/kg. Although slight pigmentation in the renal proximal tubular epithelium was observed in females at 240 mg/kg, this was not considered to be an adverse effect because of the lack of changes in related toxicological parameters. It was concluded that the NOAEL is 80 mg/kg/day in newborn rats and 240 mg/kg/day in young rats, with unequivocally toxic levels of 240 mg/kg/day and 720 mg/kg/day, respectively. Based on these two endpoints, the susceptibility of newborn rats to the chemical was approx. 3 times higher than that of young rats, consistent with our previous results for 4-nitrophenol and 2, 4-dinitrophenol.
- 日本トキシコロジー学会の論文
- 2002-12-25
著者
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HASEGAWA Ryuichi
Division of Medical Safety Science, National Institute of Health Sciences
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Hasegawa Ryuichi
ボゾリサーチセンター
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Hasegawa Ryuichi
National Institute Of Health Sciences
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Hasegawa Ryuichi
Division Of Toxicology National Institute Of Health Sciences
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KAMATA Eiichi
Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Science
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Kamata E
National Institute Of Health Sciences
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SUNAGA Masao
Safety Research Division, Safety Research Institute for Chemical Compounds Co., Ltd.
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NISHIMURA Nobuo
Gotemba Laboratory, BOZO Research Center Inc.
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ENAMI Tomonori
Gotemba Laboratory, BOZO Research Center Inc.
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KOIZUMI Mutsuko
Division of Risk Assessment, National Institute of Health Sciences
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Kamata Eiichi
Division Of Risk Assessment Biological Safety Research Center National Institute Of Health Sciences
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Nishimura Nobuo
ボゾリサーチセンター
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Hasegawa Ryuich
Division Of Toxicology National Institute Of Health Sciences
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HORIKAWA Hironao
Safety Research Institute for Chemical Compounds Co., Ltd.
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Hasegawa Ryuichi
Division Of Medical Safety Science
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Hasegawa Ryuichi
Department Of Intensive Care Medicine Tohoku University Hospital
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Sunaga M
Safety Res. Inst. Chemical Compounds Co. Ltd. Hokkaido Jpn
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Enami Tomonori
Bozo Research Center Inc. Gotemba Laboratory
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Kamata Eiichi
National Institute Of Hygienic Sciences
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Nishimura Nobuo
Gotemba Laboratory Bozo Research Center
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Koizumi Mutsuko
Division Of Risk Assessment Biological Safety Research Center National Institute Of Health Sciences
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Koizumi Mutsuko
Division Of Medicinal Safety Science National Institute Of Health Sciences
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Enami Tomonori
Gotemba Laboratory Bozo Research Center Inc.
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Horikawa Hironao
Safety Research Institute For Chemical Compounds Co. Ltd.
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Kamata Eiichi
Division Of Risk Assessment Biological Safery Research Center National Institute Of Health Sciences
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Koizumi Mutsuko
Division Of Risk Assessment National Institute Of Health Sciences
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Koizumi Mutsuko
Division Of Risk Assessment Biological Safely Research Center National Institute Of Health Sciences
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Hirata Koizumi
Division Of Risk Assessment Biological Safely Research Center National Institute Of Health Sciences
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