Therapeutic Monoclonal Antibodies
スポンサーリンク
概要
- 論文の詳細を見る
Over a hundred years has passed since the discovery of the "magic bullet" serum therapy by Kitasato and Behring, the first ever therapeutic use of antibodies. More than 80 years later, the investigation of immunoglobulin structure and function and the development of cell and molecular biology introduced the production of monoclonal antibodies (MoAbs). In the 35 years since the first process for creating MoAbs was introduced, they have remained the centerpiece of the growing biotechnology and pharmaceutical industry. Herein, I review the history, development, and clinical settings of therapeutic MoAbs that have had a significant impact on life-saving medicine.
- The Keio Journal of Medicineの論文
- 2011-06-01
著者
-
YAMADA Taketo
Department of Pathology, School of Medicine, Keio University
-
Yamada Taketo
Department Of Pathology School Of Medicine Keio University
-
Yamada Taketo
Department Of Microbiology And Immunology School Of Medicine Keio University
-
YAMADA Taketo
Department of Anesthesiology, School of Medicine, Keio University
関連論文
- Altered cellular immunity in transgenic mice with T cell-specific expression of human D4-guanine diphosphate-dissociation inhibitor (D4-GDI)
- DIOXINS IN BILE IN RELATION TO THOSE IN THE HUMAN LIVER AND BLOOD
- Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in colorectal cancer
- Establishment of an ovarian metastasis model and possible involvement of E-cadherin down-regulation in the metastasis
- Tumor angiogenesis in the bone marrow of multiple myeloma patients and its alteration by thalidomide treatment
- Thalidomide for the Treatment of Refractory Multiple Myeloma : Association of Plasma Concentrations of Thalidomide and Angiogenic Growth Factors with Clinical Outcome
- Elevated Level of Plasma Basic Fibroblast Growth Factor in Multiple Myeloma Correlates with Increased Disease Activity
- PE-217 Autoimmunity Against Type 2 Muscarinic Acetylcholine Receptor Induces Myocaditis Followed by Dilated Cardiomyopathy in Mice(Cardiomyopathy, basic/clinical-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Effect of Storage Temperature on Cell Viability in Cryopreserved Canine Aortic, Pulmonic, Mitral, and Tricuspid Valve Homografts
- Specific expression of hepatocyte nuclear factor-1β in the ovarian clear cell adenocarcinoma and its application to cytological diagnosis
- Primary bone carcinosarcoma: Chondrosarcoma and squamous cell carcinoma with keratin pearl formation
- Amiodarone-related pulmonary mass and unique membranous glomerulonephritis in a patient with valvular heart disease : Diagnostic pitfall and new findings
- Responsiveness of chemotherapy based on the histological type and Wilms' tumor suppressor gene mutation in bilateral Wilms' tumor
- Apoptosis of Human Embryonal Carcinoma Cells with in vitro Differentiation
- Gliomatosis Cerebri Mimicking Chemotherapy-Induced Leukoencephalopathy in a Patient with non-Hodgkins Lymphoma
- Aortic Intramural Hematoma With Severe Aortic Regurgitation
- Simple and Rapid Method for Detection of Apoptotic Cells by Flow Cytometry
- Prospective study of combination therapy with low-dose thalidomide plus prednisolone ameliorating cytopenia in primary myelofibrosis
- Therapeutic Monoclonal Antibodies
- Transgenic rescue of desmoglein 3 null mice with desmoglein 1 to develop a syngeneic mouse model for pemphigus vulgaris