Malignant Histiocytosis with Marked Cellular Atypia : An Autopsy Case with an Immunohistochemical Study on Neoplastic Histiocytes
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概要
- 論文の詳細を見る
A 71-year-old male presenting high fever, pancytopenia, liver dysfunction and jaundice died without a confirmed diagnosis. Microscopically, histiocytes with marked atypia and erythrophagocytosis had infiltrated the spleen, enlarged lymph nodes, liver, and bone marrow. From the above features this case was diagnosed as malignant histiocytosis. The infiltrating histiocytes were classified into three categories: 1) phagocytic cells, 2) atypical, mostly non-phagocytic cells, and 3) bizarre cells including multinucleated giant cells. An immunohistochemical study of histiocyte markers demonstrated that lysozyme was positive in the atypical cells and some phagocytic cells, whereas alpha-1-antitrypsin tended to be localized in the phagocytic cells. Bizarre cells were negative for both markers. No S-100 protein was demonstrated in the neoplastic cells. These immunohistochemical features suggested monocyte-phagocytic origin of the tumor in this case.
- 東海大学の論文
著者
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SHIMAMURA Kazuo
Department of Pathology, Tokai University School of Medicine
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ARIMORI Shigeru
Department of Internal Medicine, School of Medicine, Tokai University
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Sato Teiko
Department Of Pathology Tokai University School Of Medicine
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Sato Teiko
Department Of Pathology School Of Medicine Tokai University
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YAMAUCHI Kunihiko
Department of Internal Medicine, Tokai University School of Medicine
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UEYAMA Yoshito
Department of Pathology, School of Medicine, Tokai University
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TAMAOKI Norikazu
Department of Pathology, School of Medicine, Tokai University
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Yamauchi Kunihiko
Department Of Internal Medicine School Of Medicine Tokai University
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Ueyama Y
Dep. Of Pathology Tokai Univ. School Of Medicine
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Ueyama Y
Tokai Univ. School Of Medicine Kanagawa Jpn
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Ueyama Y
Tokai Univ. School Of Medicine Isehara‐shi Jpn
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Ueyama Yoshito
Department Of Pathology Tokai University School Of Medicine
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Tamaoki N
Central Inst. For Experimental Animals
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Sato Teiko
Department Of Pathology Asahikawa Kosei Hospital
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Yamauchi Kunihiko
Department Of Condensed Matter Physics The Institute Of Scientific And Industrial Research Osaka Uni
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Tani N
The 6th Department Of Internal Medicine School Of Medicine Tokai University
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Ueyama Yoshito
Department Of Pathology School Of Medicine Tokai University
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Tani Norio
The 6th Department Of Internal Medicine School Of Medicine Tokai University
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Shimamura Kazuo
Department Of Pathology Tokyo University School Of Medicine
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Shimamura Kazuo
Department Of Advanced Cardiovascular Therapuitics Osaka University Graduate School Of Medicine
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Arimori Shigeru
Department Of Intenal Medicine School Of Medicine Tokai University
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Tamaoki Norikazu
Central Inst. For Experimental Animals
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Tamaoki Norikazu
Department Of Pathology School Of Medicine Tokai University
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Umezawa Y
Department Of Dermatology Tokai University School Of Medicine
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Ueyama Yoshihito
Department Of Pathology Tokai University School Of Medicine
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UEYAMA Yoshito
Department of Dermatology, Division of Specialized Clinical Science, Tokai University School of Medicine
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