Expression of MHC Class II Antigens and Other T Cell Activation Antigens on T Cells and Salivary Duct Epithelial Cells in the Salivary Gland of Cases of Sjogren's Syndrome
スポンサーリンク
概要
- 論文の詳細を見る
We studied infiltrating T cells and salivary duct epithelial cells in the sublingual glands of 10 patients with primary Sjogren's syndrome (SS) using monoclonal antibodies (MoAb) to T cell subsets (OKT-series), natural killer cells (Leu7) and activation antigens of T cells such as OKT10, OKT9, interleukin 2 receptor (anti-Tac antibody) and major histocompatibility complex (MHC) class II antigens (anti-DR and anti-DQ antigens). DR antigens were identified on salivary duct epithelial cells, suggesting that the cells might function as antigen-presenting cells (APC). Among the salivary duct epithelial cells, OKT8+ cells, which are known to be suppresor/cytotoxic cells, were found in 9 out of 10 patients. Three types of mononuclear cell infiltrations were also evaluated separately: (1) periductal foci, (2) periacinal foci and (3) lymph follicles. We found that the majority of the infiltrating cells in the central portion of the periductal foci were activated T cells (OKT3+, OKT4+, OKIa-1+, DR+ and DQ+), but OKT9, OKT10 and Tac antigens were rarely found in this portion. However, most of the infiltrating cells in the peripheral portion of the periductal foci were OKT10+, and some of them were also positive for OKT9 antigen (transferrin receptor). The results indicated that the T cells in the peripheral portion of the periductal foci are at an early or intermediate phase of activation, whereas the T cells around the salivary ducts are at a later phase. Infiltrating cells in the periacinal foci resembled the cells on the peripheral portion of the periductal foci. Cells within lymph follicles were mainly B cells although scattered OKT4+ or OKT8+ cells were also present.
- 東海大学の論文
著者
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SHIMIZU Hiroaki
Department of Neurosurgery, Tohoku University Graduate School of Medicine
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Takaya Masatoshi
Department Of Internal Medicine 4 Tokai University School Of Medicine
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ARIMORI Shigeru
Department of Internal Medicine, School of Medicine, Tokai University
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MORIUCHI Junko
Department of Internal Medicine, Tokai University School of Medicine
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Moriuchi Junko
Departments Of Internal Medicine 4 Tokai University School Of Medicine
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Moriuchi Junko
Department Of Internal Medicine Tokai University School Of Medicine
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Arimori Shigeru
Department Of Internal Medicine Tokai University School Of Medicine
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Arimori Shigeru
東海大学 内科
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Arimori Shigeru
The Fourth Department Of Internal Medicine Tokai University
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ICHIKAWA Yukinobu
Department of Internal Medicine, Tokai University School of Medicine
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UCHIYAMA Mitsuaki
Department of Internal Medicine, Tokai University School of Medicine
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Shimizu Hiroaki
Departments Of Internal Medicine Tokai University School Of Medicine
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Shimizu Hiroaki
東海大学 内科
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Uchiyama Mitsuaki
Department Of Internal Medicine 4 Tokai University School Of Medicine
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Uchiyama Mitsuaki
東海大学 内科
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Takaya M
Department Of Internal Medicine 4 Tokai University School Of Medicine
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Tokunaga Masahito
東海大学 内科
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Ichikawa Y
Department Of Internal Medicine 4 Tokai University School Of Medicine
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Ichikawa Yukinobu
東海大学 内科
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Shimizu H
Department Of Internal Medicine Tokai University School Of Medicine
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Tokunaga M
Department Of Internal Medicine Tokai University School Of Medicine
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Ichikawa Yukinobu
Department Of Internal Medicine 4 Tokai University School Of Medicine
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Arimori Shigeru
Department Of Intenal Medicine School Of Medicine Tokai University
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Shimizu Hiroaki
Department Of Electrical And Computer Engineering Nagoya Institute Of Technology
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Takaya Masatoshi
Department Of Internal Medicine Tokai University School Of Medicine
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Takaya M
Department Of Internal Medicine Tokai University School Of Medicine
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Takaya Masatoshi
Tokai Univ. Isehara Jpn
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Tokunaga M
Department Of Internal Medicine 4 Tokai University School Of Medicine
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Arimori Shigeru
Tokai Univ. Isehara
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Takaya Masatoshi
Department Of Internal Medicine School Of Medicine
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SHIMIZU Hiroaki
Department of Applied Chemistry, Faculty of Engineering, Osaka University
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