Clinical Trial of Ambroxol (Mucosolvan^[○!R]) in Sjogren's Syndrome
スポンサーリンク
概要
- 論文の詳細を見る
A clinical trial is described in which twelve patients with Sjogren's Syndrome (SS) were given a dose of 135mg ambroxol (Mucosolvan^[○!R]) daily for eight weeks. Nine of the patients completed the trial. Three patients dropped out because they developed side effects (generalized rashes in two patients and stomatitis in one). The side effects, however, were mild and cleared off after cessation of treatment. Ambroxol improved sicca symptoms, especially ocular symptoms, in the SS patients, although lacrimal and salivary gland functions measured by Schirmer test or gum test were not changed. Furthermore, the treatment did not alter any chemical findings determined in the stimulated tear and saliva. Our results suggest that ambroxol is useful for the management of sicca symptoms in some patients with SS.
- 東海大学の論文
著者
-
SHIMIZU Hiroaki
Department of Neurosurgery, Tohoku University Graduate School of Medicine
-
Takaya Masatoshi
Department Of Internal Medicine 4 Tokai University School Of Medicine
-
ARIMORI Shigeru
Department of Internal Medicine, School of Medicine, Tokai University
-
MORIUCHI Junko
Department of Internal Medicine, Tokai University School of Medicine
-
Moriuchi Junko
Departments Of Internal Medicine 4 Tokai University School Of Medicine
-
Moriuchi Junko
Department Of Internal Medicine Tokai University School Of Medicine
-
Arimori Shigeru
Department Of Internal Medicine Tokai University School Of Medicine
-
Arimori Shigeru
東海大学 内科
-
Arimori Shigeru
The Fourth Department Of Internal Medicine Tokai University
-
ICHIKAWA Yukinobu
Department of Internal Medicine, Tokai University School of Medicine
-
TOKUNAGA Masahito
Department of Internal Medicine, School of Medicine, Tokai University
-
Shimizu Hiroaki
Departments Of Internal Medicine Tokai University School Of Medicine
-
Shimizu Hiroaki
東海大学 内科
-
Takaya M
Department Of Internal Medicine 4 Tokai University School Of Medicine
-
Tokunaga Masahito
東海大学 内科
-
Tokunaga Masahito
Department Of Haematology And Immunology Kagoshima University Hospital
-
Ichikawa Y
Department Of Internal Medicine 4 Tokai University School Of Medicine
-
Ichikawa Yukinobu
東海大学 内科
-
Shimizu H
Department Of Internal Medicine Tokai University School Of Medicine
-
Tokunaga M
Department Of Internal Medicine Tokai University School Of Medicine
-
Ichikawa Yukinobu
Department Of Internal Medicine 4 Tokai University School Of Medicine
-
Arimori Shigeru
Department Of Intenal Medicine School Of Medicine Tokai University
-
Shimizu Hiroaki
Department Of Electrical And Computer Engineering Nagoya Institute Of Technology
-
Takaya Masatoshi
Department Of Internal Medicine Tokai University School Of Medicine
-
Takaya M
Department Of Internal Medicine Tokai University School Of Medicine
-
Takaya Masatoshi
Tokai Univ. Isehara Jpn
-
Tokunaga M
Department Of Internal Medicine 4 Tokai University School Of Medicine
-
Arimori Shigeru
Tokai Univ. Isehara
-
Takaya Masatoshi
Department Of Internal Medicine School Of Medicine
-
SHIMIZU Hiroaki
Department of Applied Chemistry, Faculty of Engineering, Osaka University
関連論文
- De Novo Formation of Orbital Cavernous Malformation 9 Years After Surgical Management of Dural Arteriovenous Fistula in the Anterior Middle Fossa : Case Report
- Asymptomatic Moyamoya Disease Subsequently Manifesting as Transient Ischemic Attack, Intracerebral Hemorrhage, and Subarachnoid Hemorrhage in a Short Period : Case Report
- Papillary Necrosis and the Antinuclear Factor
- Acute Pancreatitis and Cushing's Disease
- Cardiac Tamponade in the Blastic Crisis of Chronic Myelogenous Leukemia
- Sjogren's Syndrome and Pregnancy
- Antiphospholipid Antibodies in Systemic Lupus Erythematosus
- Expression of MHC Class II Antigens and Other T Cell Activation Antigens on T Cells and Salivary Duct Epithelial Cells in the Salivary Gland of Cases of Sjogren's Syndrome
- A Clinical Study of Patients with Idiopathic Thrombocytopenic Purpura
- Anticardiolipin Antibodies by an Enzyme-Linked Immunosorbent Assay : Fundamental Studies on the Conditions for Antigen-Application and Specificity of the Assay
- B-Cell Malignant Lymphoma Associated with Monoclonal Macroglobulinemia and Cryoglobulinemia
- Clinical Trial of Ambroxol (Mucosolvan^[○!R]) in Sjogren's Syndrome
- Prospective Studies on the Progress of Sicca Symptoms in Sjogren's Syndrome : Subclinical Disease Develops into the Clinical Syndrome
- Report of a Case with Chronic Myelomonocytic Leukemia : Demonstration of Leukemic Monocytes Lacking Nonspecific Esterase by Flowcytometry Using Monoclonal Antibodies
- Nodular Sclerosing Hodgkin's Disease with Massave Skin Invasion
- Alloimmunization Following Platelet Transfusions in Patients with Acute Nonlymphocytic Leukemia
- A Study of Correlation between Histological, Staging Classification and Prognosis of Malignant Lymphoma
- Trial of Long-Term Leukapheresis in the Treatment of Adult T-Cell Leukemia
- A Case Report of Henoch-Schoenlein Purpura Nephritis Associated with a Postbulbar Duodenal Ulcer
- Hyperosmolar Nonketotic Diabetic State Associated with Disseminated Intravascular Coagulation and Acute Renal Failure : A Case Report
- Impaired Granulocyte Function in Patients with Diabetes Mellitus
- Experimental Induction of Sialadenitis in Rats by Heterologous Anti-Salivary Gland Antibodies
- Immunofluorescent Studies on Acute Phase Reactants in Patients with Various Types of Chronic Glomerulonephritis
- Comparison of Protected Isolation Techniques between the Laminar Airflow Room and the Life Island Unit
- Malignant Histiocytosis with Marked Cellular Atypia : An Autopsy Case with an Immunohistochemical Study on Neoplastic Histiocytes
- Quantitative assessment using visual analog scales for sicca symptoms of sjogren's syndrome
- Evaluation of Cefmetazole and Piperacillin with or without Tobramycin for Infections in Patients with Hematological Disorders
- Chemoimmunotherapy with Krestin in Acute Leukemia
- Human Bone Marrow Contains Fibroblast Colony Forming Cells
- A case of systemic lupus erythematosus with various central and pripheral neurological disorders developed with motor paralytic bladder as a major manifestation
- Psychological stress, disease activity and functional disability in patients with rheumatoid arthritis : a comparison with other chronic rheumatic or autoimmune disease patients
- Comparison of Antinuclear Antibody and Other Immunohematological Profiles among Primary Sjogren's Syndrome, Secondary Sjogren's Syndrome Associated with Rheumatoid Arthritis or Systemic Lupus Erythematosus, and Corresponding Systemic Disease
- Thrombomodulin levels in the plasma and joint fluid from patients with rheumatoid arthritis
- A Case of Acute Myeloblastic Leukemia with Chromosomes Showing 46, XY=11/46, XY, 21q-=39
- Bone Marrow Fibroblasts-Conditioned Medium Regulates the Proliferation of Leukemic Cells
- Small-dose Cytosine Arabinoside in the Treatment of Elderly Patients with Acute Leukemia and Refractory Anemia with Excess of Blast
- Septicemia during Compromised Host Treated in a Protected Isolation Unit
- The Effect of Bestatin on Patients with Acute and Chronic Leukemia and Malignant Lymphoma
- Bacteriological Evaluation of an Isolation Ward during Patient Occupancy
- The Utility of Protective Environment and Prophylactic Antibiotics in the Therapy of Leukemia
- The Level of Purification and Sterilization Methods in the Bioclean Room
- Sialographical diagnosis of Sjogren's syndrome : comparison between high osmotic (ionic) and low osmotic (non-ionic) contrast media
- Retrovirus-like Particles in Human Thymomas
- Characterization of Sicca Symptoms in Patients with Sjogren's Syndrome, and Reports of Six Cases Lacking Subjective Sicca Features ("Subclinical Sjogren's Syndrome")
- Spinal Granulocytic Sarcoma Manifesting as Radiculopathy in a Nonleukemic Patient
- Congestive Myelopathy Due to Cervical Perimedullary Arteriovenous Fistula Evaluated by Apparent Diffusion Coefficient Values : Case Report
- Decreased Insulin Binding of Mononuclear Leukocytes in Diabetic Patients with Hyperlipidemia
- Significance of LDL binding Lymphocytes in Patients with Hyperlipidemia
- Studies on Insulin Binding Activity of Diabetic Neutrophils
- Clinical Evaluation of 117 Patients with Sjogren's Syndrome
- Circulating Immune Complexes in Sjogren's Syndrome
- Lymphocytotoxic Antibody in Sjogren's Syndrome
- Cellular Immunity to Secretory IgA (As a Common Duct Antigen of Exocrine Glands) in Sjogren's Syndrome
- Correlation between Postsialographical Changes of Salivary Isoamylase Levels in Serum and Histopathological Findings in Sublingual Glands in Patients with Sjogren's Syndrome
- Antibody-Dependent Cell-Mediated Cytotoxicity by Peripheral Blood Mononuclear Cells from Patients with Sjogren's Syndrome, with Special Reference to Differentiation from Phagocytic Activity
- Clinical Studies on Patients with Systemic Lupus Erythematosus Associated with Sjogren's Syndrome
- Prevention of Symptomatic Vasospasm After Aneurysmal Subarachnoid Hemorrhage by Intraoperative Cisternal Fibrinolysis Using Tissue-Type Plasminogen Activator Combined With Continuous Cisternal Drainage
- Clinical features of Sjogren's syndrome associated with recurrent annular erythema
- Molecular markers of coagulation and fibrinolysis as indicators for the disease activity of rheumatoid arthritis
- Spontaneous and anti-Fas antibody-mediated apoptosis of the peripheral blood lymphocytes in Sjogren's syndrome, rheumatoid arthritis and systemic lupus erythematosus
- Decay-Accelerating Factor (DAF, CD55)-Negative T Lymphocytes in the Peripheral Blood of Sjogren's Syndrome Patients
- Usefulness of intraoperative fluorescence imaging to evaluate local anatomy in hepatobiliary surgery
- High-level Expression of P-glycoprotein and 85 kD Protein as Assessed by Flow Cytometry and Immunocytochemistry in Leukemias and Malignant Lymphomas
- Increase in Pulmonary Blood Flow during Cold Stimulation of the Mouth in Patients with Systemic Lupus Erythematosus
- Effective Methylprednisolone "Pulse" Therapy in Myeloerythroid Aplasia Associated with Systemic Lupus Erythematosus : Case Report and Literature Review
- Correlation of Suppressor T Cell Function and T Cell Subsets in Systemic Lupus Erythematosus
- Prognostic Factors in Adult Patients with Acute Leukemia
- Recent advance in the treatment of hilar cholangiocarcinoma : hepatectomy with vascular resection
- Ultrastructure of Mutual Adhesion and Multinuclearity of Erythroblasts in a Patient with Dyserythropoietic Anemia
- A Case of Intrasellar Craniopharyngioma
- A Case Report of Aldosterone Producing Adenoma with Masked Hyperaldosteronemia
- Factor VIII, von Willebrand Factor and Platelet Adhesiveness in Diabetic Retinopathy
- Influence of Pantethine on Platelet Volume, Microviscosity, Lipid Composition and Functions in Diabetes Mellitus with Hyperlipidemia
- A New Method to Quantitate Lipid Contents in Human Platelets by Thin Layer Chromatography with Flame lonization Detection
- Bone Marrow Transplantation in Children
- Clinical Implications of Unusual NeuroD and mASH1 Expression in a Patient with Primary Large-Cell Neuroendocrine Carcinoma of the Duodenum : Report of a Case
- Abnormal Regulation of Granulopoiesis by Bone Marrow Fibroblasts in Leukemia
- CCAAT/enhancer binding protein-β promotes the survival of intravascular rat pancreatic tumor cells via antiapoptotic effects
- Treatment with an oral fluoropyrimidine, S-1, plus cisplatin in patients who failed postoperative gemcitabine treatment for pancreatic cancer : a pilot study
- Right hepatectomy combined with retrohepatic caval resection, using a left renal vein patch graft for advanced cholangiocarcinoma
- Establishment of Gemcitabine-Resistant Human Pancreatic Cancer Cells and Effect of Brefeldin-A on the Resistant Cell Line
- Extended hepatic resection and outcomes in intrahepatic cholangiocarcinoma
- Cell Surface Antigens Expressed on Polymorphonuclear Cells in the Peripheral Blood from Patients with Inflammatory Rheumatic Diseases : Two-Color Flow-cytometric Analysis
- "Yellow Nail Syndrome" and Rheumatoid Arthritis
- Erythrocyte Superoxide Dismutase in Various Hematological Diseases
- In Vitro and In Vivo Evaluation of Prolonged Release Microspheres and Tablets Containing Calcitonin Gene-related Peptide
- Bypass Surgery for Occluded Internal Carotid Artery Revascularized by Vasa Vasorum : Case Report
- Superoxide Scavenging Activity of Leukocytes in Rheumatoid Arthritis and Behcet's Diseases
- Thoracic Intradural Arachnoid Cyst Associated With Surgical Removal of Epidural Hematoma
- Intramedullary Spinal Tuberculoma : Case Report
- Effect of Pantethine on ADP-Induced Aggregation, Microviscosity and Ultramicrostructure of Human Platelets
- Immunosuppression Following Surgical and Traumatic Injury
- Nonoliguric Acute Renal Failure in Acute Pancreatitis
- One hundred seven consecutive surgical resections for hilar cholangiocarcinoma of Bismuth types II, III, IV between 2001 and 2008
- Surgical strategy for mucin-producing bile duct tumor
- Immunological Mechanisms of Cytotoxicity in Patients with Chronic Glomerulonephritis
- A New Approach to the Treatment of Myasthenia Gravis : Continuous Administration of Small Doses of Prednisolone
- Differences of Microviscosity and Lipid Composition in Normal Human T and B Lymphocytes
- T Lymphoreceptopathy in Systemic Lupus Erythematosus
- Antibodies Against Myofibrillar Proteins in Myasthenia Gravis Patients