Thrombomodulin levels in the plasma and joint fluid from patients with rheumatoid arthritis
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概要
- 論文の詳細を見る
The hemostatic mechanism is thought to contribute to the inflammatory process of rheumatoid arthritis (RA). Thrombomodulin (TM), an inhibitor of blood coagulation, is synthesized by various cells which are recognized in the inflammatory lesions of RA. To elucidate a possible relation of TM with the process of RA, therefore, we measured soluble forms of TM in the plasma and joint fluid (JF) from RA patients by a recently developed sandwich enzyme immunoassay using monoclonal antibodies. TM levels in the plasma and JF were not significantly elevated in RA patients, although TM levels in plasma were positively correlated with those in JF. The plasma TM levels were related to renal functions (serum creatinine levels), but the levels showed no connection with systemic inflammatory indices of RA such as erythrocyte sedimentation rates, serum C-reactive protein levels and Lansbury's activity index. In the JF, TM levels were not correlated with the numbers of neutrophils or monocytes/macrophages associated with articular inflammations. Our results indicate that TM levels in the plasma and JF do not reflect systemic and articular inflammations of RA, and suggest that TM molecules in JF are mainly recruited from circulating TM.
- 東海大学の論文
著者
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SHIMIZU Hiroaki
Department of Neurosurgery, Tohoku University Graduate School of Medicine
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Takaya Masatoshi
Department Of Internal Medicine 4 Tokai University School Of Medicine
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MORIUCHI Junko
Department of Internal Medicine, Tokai University School of Medicine
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Moriuchi Junko
Departments Of Internal Medicine 4 Tokai University School Of Medicine
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Moriuchi Junko
Department Of Internal Medicine Tokai University School Of Medicine
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ICHIKAWA Yukinobu
Department of Internal Medicine, Tokai University School of Medicine
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UCHIYAMA Mitsuaki
Department of Internal Medicine, Tokai University School of Medicine
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MORITA Kazuyuki
Department of Internal Medicine, School of Medicine, Tokai University
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Shimizu Hiroaki
Departments Of Internal Medicine Tokai University School Of Medicine
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Shimizu Hiroaki
東海大学 内科
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Uchiyama Mitsuaki
Department Of Internal Medicine 4 Tokai University School Of Medicine
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Uchiyama Mitsuaki
東海大学 内科
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Tokunaga Masahito
東海大学 内科
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Morita Kazuyuki
Department Of Internal Medicine Tokai University School Of Medicine
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Ichikawa Y
Department Of Internal Medicine 4 Tokai University School Of Medicine
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Ichikawa Yukinobu
東海大学 内科
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Mishima Kengo
Department Of Internal Medicine Tokai University School Of Medicine
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Mishima Kengo
東海大学 内科
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HORIKI Terumi
Departments of Internal Medicine 4, Tokai University School of Medicine
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Shimizu H
Department Of Internal Medicine Tokai University School Of Medicine
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HOSHINA Yuichi
Department of Internal Medicine, Tokai University School of Medicine
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Horiki Terumi
Department Of Internal Medicine 4 Tokai University School Of Medicine
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Horiki T
Departments Of Internal Medicine 4 Tokai University School Of Medicine
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Tokunaga M
Department Of Internal Medicine Tokai University School Of Medicine
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Hoshina Yuichi
Department Of Internal Medicine 4 Tokai University School Of Medicine
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Ichikawa Yukinobu
Department Of Internal Medicine 4 Tokai University School Of Medicine
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Shimizu Hiroaki
Department Of Electrical And Computer Engineering Nagoya Institute Of Technology
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Mishima Kengo
Department Of Internal Medicine Tokai University School Of Medicine Isehara Kanagawa
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Takaya M
Department Of Internal Medicine Tokai University School Of Medicine
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Takaya Masatoshi
Tokai Univ. Isehara Jpn
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Tokunaga M
Department Of Internal Medicine 4 Tokai University School Of Medicine
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Takaya Masatoshi
Department Of Internal Medicine School Of Medicine
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SHIMIZU Hiroaki
Department of Applied Chemistry, Faculty of Engineering, Osaka University
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