Modulation of Peripheral Blood Lymphocyte Subsets during Methylprednisolone Pulse Therapy

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概要

• 論文の詳細を見る

• We determined fluctuations in circulating lymphocyte subsets induced by methylprednisolone pulse therapy (MPT) and the continuous administration of prednisolone (PSL) in 17 patients with autoimmune or systemic rheumatic disease. Two-color flow cytometry, using monoclonal antibodies to various lymphocyte subsets, was perfomed to identify a possible association between the clinical efficacy of treatment and modulative effects on each subset. Both MPT and continuous oral PSL showed suppressive effects on most of the lymphocyte subsets: CD4^+, CD45RA^- or CD45RA^+CD4^+, CD8^+, CD11b^-CD8^+, CD5^+ B, and CD57^+ or CD57^- CD16^+ cells. Modulation of lymphocyte subsets were more profound with MPT than with continuous oral PSL. The results are relevant to the different degrees of immuno-suppression effected by the two treatment modalities. We found that the number of CD45RA^-CD4^+ cells after MPT treatment correlated with the clinical efficacy of the treatment: the less CD45RA^-CD4^+ cell numbers decreased after MPT treatment, the greater was the clinical efficacy of the treatment. The results probably are associated with a rapid recovery of the subset after MPT treatment in the responders. Thus, the sequential monitoring of circulating lymphocyte subsets is useful in predicting the clinical effects of MPT treatment.

• 東海大学の論文

著者

• ICHIKAWA Yukinobu

  The Fourth Department of Internal Medicine, School of Medicine, Tokai University

• Ichikawa Yukinobu

  東海大学 内科

• Ichikawa Yukinobu

  4th Dept. Medicine Tokai Univ. School Of Med. Isehara

• Ichikawa Yukinobu

  Departments Of Internal Medicine 4 Tokai University School Of Medicine

• Ichikawa Y

  Departments Of Internal Medicine 4 Tokai University School Of Medicine

• FUKUDA Ryuki

  The Fourth Department of Internal Medicine, School of Medicine, Tokai University

• HORIKI Terumi

  The Fourth Department of Internal Medicine, School of Medicine, Tokai University

• SASAO Tamotsu

  The Fourth Department of Internal Medicine, School of Medicine, Tokai University

• KAWADA Hiroshi

  The Fourth Department of Internal Medicine, School of Medicine, Tokai University

• Fukuda Ryuuki

  Department Of Internal Medicine Tokai University School Of Medicine

• Fukuda Ryuki

  The Fourth Department Of Internal Medicine School Of Medicine Tokai University

• Horiki Terumi

  Department Of Internal Medicine 4 Tokai University School Of Medicine

• Horiki T

  Departments Of Internal Medicine 4 Tokai University School Of Medicine

• Sasao Tamotsu

  Departments Of Internal Medicine 4 Tokai University School Of Medicine

• Kawada Hiroshi

  The Fourth Department Of Internal Medicine School Of Medicine Tokai University

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