Experimental Induction of Sialadenitis in Rats by Heterologous Anti-Salivary Gland Antibodies

スポンサーリンク

概要

• 論文の詳細を見る

• The purpose of the present study was to investigate the possibility of experimental induction of sialadenitis in rats by heterologous anti-salivary gland antibodies. Two fractions (Fractions I and II) were separated from rat submaxillary gland by Sephadex-G 200 gel-filtration, and then rabbits were immunized with each fraction. Although cross-reactivity of anti-FrI antiserum obtained from the rabbits against rat liver and rat serum was shown, specific reactivity of both anti-FrI and anti-FrII antisera against rat submaxillary gland was demonstrated by immunodiffusion or the indirect immunofluorescence method. Activity of antibody-dependent cell-mediated cytotoxicity against fresh rat submaxillary gland was also demonstrated using the anti-FrII antiserum in vitro. Sialadenitis with periductal cell infiltrations was induced in the submaxillary glands of many rats injected intraperitoneally with each heterologous antiserum. Similar lesions, however, were also induced in the parotid glands, livers, or kidneys of these rats. By a direct immunofluorescence method, granular deposits of rabbit gammaglobulin were detected in cytoplasma of the infiltrating cells and the small vessels around the lesions of the submaxillary glands. It was suggested, therefore, that the lesions are induced by circulating immune complexes probably formed by non-organspecific antibodies contaminating each antiserum. Salivary gland lesions induced by a similar mechanism were also suggested in patients with Sjogren's syndrome, although the pathological significance in vivo of the anti-salivary gland antibody as an organspecific antibody could not be confirmed by the present study.

• 東海大学の論文

著者

• Takaya Masatoshi

  Department Of Internal Medicine 4 Tokai University School Of Medicine

• Arimori Shigeru

  Department Of Internal Medicine Tokai University School Of Medicine

• Arimori Shigeru

  東海大学 内科

• Arimori Shigeru

  The Fourth Department Of Internal Medicine Tokai University

• ICHIKAWA Yukinobu

  The Fourth Department of Internal Medicine, School of Medicine, Tokai University

• TAKAYA Masatoshi

  The Fourth Department of Internal Medicine, School of Medicine, Tokai University

• Takaya M

  Department Of Internal Medicine 4 Tokai University School Of Medicine

• Tokunaga Masahito

  東海大学 内科

• Ichikawa Y

  Department Of Internal Medicine 4 Tokai University School Of Medicine

• Ichikawa Yukinobu

  東海大学 内科

• Tokunaga M

  Department Of Internal Medicine Tokai University School Of Medicine

• Takaya Masatoshi

  Department Of Internal Medicine Tokai University School Of Medicine

• Takaya M

  Department Of Internal Medicine Tokai University School Of Medicine

• Takaya Masatoshi

  The Fourth Department Of Internal Medicine School Of Medicine Tokai University

• Arimori Shigeru

  The Fourth Department Of Internal Medicine School Of Medicine Tokai University

• Takaya Masatoshi

  Tokai Univ. Isehara Jpn

• Tokunaga M

  Department Of Internal Medicine 4 Tokai University School Of Medicine

• Arimori Shigeru

  Tokai Univ. Isehara

• Takaya Masatoshi

  Department Of Internal Medicine School Of Medicine

関連論文

• Acute Pancreatitis and Cushing's Disease
• Cardiac Tamponade in the Blastic Crisis of Chronic Myelogenous Leukemia
• Sjogren's Syndrome and Pregnancy
• Antiphospholipid Antibodies in Systemic Lupus Erythematosus
• Expression of MHC Class II Antigens and Other T Cell Activation Antigens on T Cells and Salivary Duct Epithelial Cells in the Salivary Gland of Cases of Sjogren's Syndrome
• A Clinical Study of Patients with Idiopathic Thrombocytopenic Purpura
• Anticardiolipin Antibodies by an Enzyme-Linked Immunosorbent Assay : Fundamental Studies on the Conditions for Antigen-Application and Specificity of the Assay
• B-Cell Malignant Lymphoma Associated with Monoclonal Macroglobulinemia and Cryoglobulinemia
• Clinical Trial of Ambroxol (Mucosolvan^[○!R]) in Sjogren's Syndrome
• Prospective Studies on the Progress of Sicca Symptoms in Sjogren's Syndrome : Subclinical Disease Develops into the Clinical Syndrome
• Report of a Case with Chronic Myelomonocytic Leukemia : Demonstration of Leukemic Monocytes Lacking Nonspecific Esterase by Flowcytometry Using Monoclonal Antibodies
• Nodular Sclerosing Hodgkin's Disease with Massave Skin Invasion
• Alloimmunization Following Platelet Transfusions in Patients with Acute Nonlymphocytic Leukemia
• A Study of Correlation between Histological, Staging Classification and Prognosis of Malignant Lymphoma
• Trial of Long-Term Leukapheresis in the Treatment of Adult T-Cell Leukemia
• Experimental Induction of Sialadenitis in Rats by Heterologous Anti-Salivary Gland Antibodies
• Comparison of Protected Isolation Techniques between the Laminar Airflow Room and the Life Island Unit
• Quantitative assessment using visual analog scales for sicca symptoms of sjogren's syndrome
• Fatal Alveolar Hemorrhage in a Patient with Mixed Connective Tissue Disease Presenting Polymyositis Features
• Modulation of Peripheral Blood Lymphocyte Subsets during Methylprednisolone Pulse Therapy
• Evaluation of Cefmetazole and Piperacillin with or without Tobramycin for Infections in Patients with Hematological Disorders
• Chemoimmunotherapy with Krestin in Acute Leukemia
• Human Bone Marrow Contains Fibroblast Colony Forming Cells
• A case of systemic lupus erythematosus with various central and pripheral neurological disorders developed with motor paralytic bladder as a major manifestation
• Psychological stress, disease activity and functional disability in patients with rheumatoid arthritis : a comparison with other chronic rheumatic or autoimmune disease patients
• Comparison of Antinuclear Antibody and Other Immunohematological Profiles among Primary Sjogren's Syndrome, Secondary Sjogren's Syndrome Associated with Rheumatoid Arthritis or Systemic Lupus Erythematosus, and Corresponding Systemic Disease
• Thrombomodulin levels in the plasma and joint fluid from patients with rheumatoid arthritis
• Bone Marrow Fibroblasts-Conditioned Medium Regulates the Proliferation of Leukemic Cells
• Small-dose Cytosine Arabinoside in the Treatment of Elderly Patients with Acute Leukemia and Refractory Anemia with Excess of Blast
• Septicemia during Compromised Host Treated in a Protected Isolation Unit
• The Effect of Bestatin on Patients with Acute and Chronic Leukemia and Malignant Lymphoma
• Bacteriological Evaluation of an Isolation Ward during Patient Occupancy
• The Utility of Protective Environment and Prophylactic Antibiotics in the Therapy of Leukemia
• The Level of Purification and Sterilization Methods in the Bioclean Room
• Sialographical diagnosis of Sjogren's syndrome : comparison between high osmotic (ionic) and low osmotic (non-ionic) contrast media
• Retrovirus-like Particles in Human Thymomas
• Characterization of Sicca Symptoms in Patients with Sjogren's Syndrome, and Reports of Six Cases Lacking Subjective Sicca Features ("Subclinical Sjogren's Syndrome")
• Clinical Evaluation of 117 Patients with Sjogren's Syndrome
• Circulating Immune Complexes in Sjogren's Syndrome
• Lymphocytotoxic Antibody in Sjogren's Syndrome
• Cellular Immunity to Secretory IgA (As a Common Duct Antigen of Exocrine Glands) in Sjogren's Syndrome
• Correlation between Postsialographical Changes of Salivary Isoamylase Levels in Serum and Histopathological Findings in Sublingual Glands in Patients with Sjogren's Syndrome
• Antibody-Dependent Cell-Mediated Cytotoxicity by Peripheral Blood Mononuclear Cells from Patients with Sjogren's Syndrome, with Special Reference to Differentiation from Phagocytic Activity
• Clinical Studies on Patients with Systemic Lupus Erythematosus Associated with Sjogren's Syndrome
• Clinical features of Sjogren's syndrome associated with recurrent annular erythema
• Molecular markers of coagulation and fibrinolysis as indicators for the disease activity of rheumatoid arthritis
• Spontaneous and anti-Fas antibody-mediated apoptosis of the peripheral blood lymphocytes in Sjogren's syndrome, rheumatoid arthritis and systemic lupus erythematosus
• Decay-Accelerating Factor (DAF, CD55)-Negative T Lymphocytes in the Peripheral Blood of Sjogren's Syndrome Patients
• Correlation of Suppressor T Cell Function and T Cell Subsets in Systemic Lupus Erythematosus
• Prognostic Factors in Adult Patients with Acute Leukemia
• Ultrastructure of Mutual Adhesion and Multinuclearity of Erythroblasts in a Patient with Dyserythropoietic Anemia
• A Case Report of Aldosterone Producing Adenoma with Masked Hyperaldosteronemia
• Influence of Pantethine on Platelet Volume, Microviscosity, Lipid Composition and Functions in Diabetes Mellitus with Hyperlipidemia
• A New Method to Quantitate Lipid Contents in Human Platelets by Thin Layer Chromatography with Flame lonization Detection
• Abnormal Regulation of Granulopoiesis by Bone Marrow Fibroblasts in Leukemia
• Cell Surface Antigens Expressed on Polymorphonuclear Cells in the Peripheral Blood from Patients with Inflammatory Rheumatic Diseases : Two-Color Flow-cytometric Analysis
• "Yellow Nail Syndrome" and Rheumatoid Arthritis
• Impaired Protection against Free Radicals in Various Immune Diseases(The 4th Joint Symposium between Tokai University School of Medicine and Semmelweis University School of Medicine 7-9, June, 1993, Budapest)
• Superoxide Scavenging Activity of Leukocytes in Rheumatoid Arthritis and Behcet's Diseases
• Effect of Pantethine on ADP-Induced Aggregation, Microviscosity and Ultramicrostructure of Human Platelets
• Immunological Mechanisms of Cytotoxicity in Patients with Chronic Glomerulonephritis
• Essential Thrombocythemia Developing into Refractory Anemia and Complicated by Acute Myeloid Leukemia
• Differences of Microviscosity and Lipid Composition in Normal Human T and B Lymphocytes
• T Lymphoreceptopathy in Systemic Lupus Erythematosus
• Fundamental Studies on Human T Lymphocyte Subsets
• Antibodies Against Myofibrillar Proteins in Myasthenia Gravis Patients
• Acquisition of CD13 and CD33 Expression at Relapse on Acute Myeloid Leukemia Cells with an Unusual Phenotype: MPO+CD13-CD33-.
• Thymic Carcinoma Associated with Pinealoma and Terminating with Peroxidase-negative Acute Myeloid Leukemia.
• Circadian Variations and Prednisolone-Induced Alterations of Circulating Lymphocyte Subsets in Man.

もっと見る 閉じる

スポンサーリンク