Abnormal Regulation of Granulopoiesis by Bone Marrow Fibroblasts in Leukemia
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概要
- 論文の詳細を見る
Effects of human bone marrow fibroblasts (BMF) on the differentiation of human colony forming units in culture (CFU-C) were investigated in five normal adults, 10 patients with acute leukemia (AL) at the time of diagnosis, five patients with AL at complete remission (CR) and six patients with chronic myelogenous leukemia (CML). To determine the effects of BMF on granulopoiesis, normal bone marrow cells were cultured in agar medium on BMF liquid-phase cultures, and the numbers of CFU-C were counted. BMF from either normal subjects, AL at the time of complete remission (CR) or CML enhanced the growth of CFU-C in a few spontaneous CFU-C groups (<3 colonies/10^5 cells), whereas BMF obtained from AL at the time of diagnosis failed to enhance the growth. In contrast, BMF from either normal subjects, AL at the time of diagnosis and CR, or CML inhibited the growth of CFU-C in many spontaneous CFU-C groups (>10 colonies/10^5 cells). BMF from AL at the time of diagnosis showed significantly higher inhibitory effect than those from normal subjects (p<0.01). When giant cell tumor-conditioned medium was used as a source of colony stimulating factor, 26 BMF in total from various subjects inhibited the growth of CFU-C except for four cases (two normal subjects and two AL patients at CR). The degree of inhibition of CFU-C growth by BMF from AL at the time of diagnosis was significantly higher than in normal subjects (p<0.01). These results show that human BMF have both inhibitory and stimulatory effects on granulopoietic progenitor cells, and that these effects are impaired in AL at the time of diagnosis.
- 東海大学の論文
著者
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Arimori Shigeru
Department Of Internal Medicine Tokai University School Of Medicine
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Arimori Shigeru
東海大学 内科
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Arimori Shigeru
The Fourth Department Of Internal Medicine Tokai University
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NAGAO Tadami
The Fourth Department of Internal Medicine, School of Medicine, Tokai University
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長尾 忠美
東海大学医学部第四内科
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Nagao Tadami
Department Of Internal Medicine Tokai University School Of Medicine
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長尾 忠美
東海大 第4内科
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Nagao Tadami
The Fourth Department Of Internal Medicine School Of Medicine Tokai University
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Shimizu Masaki
Department Of Internal Medicine School Of Medicine Tokai University
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Nagao Tadami
Internal Medicine School Of Medicine Tokai University
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SHIMIZU Masaki
The Fourth Department of Internal Medicine, School of Medicine, Tokai University
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Arimori Shigeru
The Fourth Department Of Internal Medicine School Of Medicine Tokai University
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Arimori Shigeru
Tokai Univ. Isehara
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