Platelet Activation in Patients with Chronic Hepatitis C
スポンサーリンク
概要
- 論文の詳細を見る
Objective: To elucidate the mechanisms of thrombocytopenia in chronic hepatitis C (CHC), we investigated platelet activation in patients with chronic viral liver diseases. Methods: Platelet activation was evaluated with flow cytometry in twenty-five patients with chronic viral hepatitis and 11 patients with liver cirrhosis of viral etiology. Liver biopsies were carried out in all patients. Results: The platelet counts decreased significantly in patients with CHC and in patients with liver cirrhosis compared to controls, but not in patients with chronic hepatitis B (CHB). Patients with CHC had a significantly higher percentage of platelets positive for activation-dependent monoclonal antibodies (MoAbs), and also had a higher percentage of platelet microparticles (PMP), a marker of platelet activation, than patients with CHB. There was a significant correlation between the percentage of PMP and the levels of liver fibrosis markers, such as serum hyaluronate and N-terminal propeptide of type III procollagen (P-III-P), in CHC, suggesting the relationship between platelet activation and liver fibrosis. Platelet activation was markedly enhanced in CHC patients with high histological scores of liver fibrosis. Conclusion: Patients with CHC have increased platelet activation, which may contribute to the occurrence of thrombocytopenia in CHC. Liver fibrosis may play a role in activation of platelets in CHC.
- 東海大学の論文
著者
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MIYACHI Hayato
Department of Laboratory Medicine, Tokai University School of Medicine
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Shiraishi Koichi
Department of Applied Physics, Fukuoka University
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FUSEGAWA Hisae
Department of Blood Transfusion Service Center Tokai University Hospital
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ANDO Yasuhiko
Department of Blood Transfusion Service Center Tokai University Hospital
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Fusegawa H
Department Of Internal Medicine National Hospital Organization Kanagawa National Hospital
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Miyachi H
Tokai Univ. School Of Medicine Kanagawa
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Miyachi Hayato
Department Of Laboratory Medicine Tokai University School Of Medicine
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Miyachi Hayato
東海大学 薬理
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Shimizu Masaki
Department Of Internal Medicine School Of Medicine Tokai University
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MATSUZAKI Shohei
Digestive and Liver Disease Center, Tokai University Tokyo Hospital
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MATSUZAKI Shohei
Department of Internal Medicine III, Tokai University School of Medicine
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Matsuzaki S
Digestive And Liver Disease Center Tokai University Tokyo Hospital
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Matsuzaki S
Department Of Internal Medicine Tokai University School Of Medicine
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Matsuzaki Shohei
Department Of Medicine (gastroenterology) Tokai University School Of Medicine
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Matsuzaki Shohei
Department Of Gastroenterology I Tokai University School Of Medicine
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Matsuzaki Shohei
Division Of Gastroenterology Department Of Internal Medicine Tokai University School Of Medicine
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OGASAWARA Fusao
Department of Internal Medicine, Tokai University School of Medicine
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HARUKI Yasuo
Department of Medical Informatics, Tokai University School of Medicine
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Haruki Yasuo
Department Of Anatomy School Of Medicine Tokai University
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SHIMIZU Mie
Department of Laboratory Medicine, Tokai University School of Medicine
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Matsuzaki Shouji
Department Of Urology Tokai University School Of Medicine
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Shimizu Mie
Department Of Laboratory Medicine Tokai University School Of Medicine
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Ando Y
Department Of Laboratory Medicine Tokai University School Of Medicine
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Ando Yasuhiko
Department Of Laboratory Medicine Tokai University School Of Medicine
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Ogasawara Fusao
Department Of Internal Medicine Tokai University School Of Medicine
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Haruki Y
Department Of Medical Informatics Tokai University School Of Medicine
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Shiraishi Koichi
Department Of Internal Medicine Tokai University School Of Medicine
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Shiraishi Koichi
Department Of Applied Physics Fukuoka University
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MIYACHI HAYATO
Department of Internal Medicine, School of Medicine, Keio University
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