Platelet Activation in Patients with Alcoholic Liver Disease
スポンサーリンク
概要
- 論文の詳細を見る
Objective: To elucidate the mechanisms of thrombocytopenia in alcoholic liver diseases, we investigated activation status of platelets in patients with alcoholic fatty liver (Al-FL), alcoholic liver cirrhosis (Al-LC) or hepatitis-C liver cirrhosis C (C-LC). Methods: Platelet activation was evaluated by flow cytometry using monoclonal antibodies against P-selectin (CD62P) and the fibrinogen receptor (PAC-1), both specific for platelet activation, and anti-CD61 antibody for the presence of microparticles (PMP) in seven patients with Al-FL, thirteen patients with Al-LC and, as a non-alcoholic liver disease control, nine patients with C-LC. As a normal control, seventeen healthy subjects without liver dysfunction were also evaluated. Results: Compared with the healthy controls, the platelet count was significantly decreased in patients with alcoholic liver diseases or C-LC. Ten days after discontinuation of alcohol intake, the platelet count was significantly higher in both the Al-FL and Al-LC groups than that measured on admission. There was an inverse correlation between the platelet count and PMP, a marker of platelet activation. The Al-FL, Al-LC and C-LC groups showed significantly higher percentages of platelets positive for CD62P than the healthy controls. The PAC-1 positivity was increased only in the C-LC group. PMP were significantly increased in the Al-FL, Al-LC and C-LC groups compared to that in the healthy group. In the Al-LC group, PMP were significantly decreased 10 days after discontinuation of alcohol intake from that measured on admission. Conclusion: Patients with alcoholic liver diseases have increased platelet activation, which may contribute to the occurrence of thrombocytopenia. The formation of PMP might be one of the important factors of thrombocytopenia in alcoholic liver diseases.
- 東海大学の論文
著者
-
Shiraishi Koichi
Department of Applied Physics, Fukuoka University
-
FUSEGAWA Hisae
Department of Blood Transfusion Service Center Tokai University Hospital
-
Fusegawa H
Department Of Internal Medicine National Hospital Organization Kanagawa National Hospital
-
Watanabe Norihito
Department Of Internal Medicine Tokai University School Of Medicine
-
Watanabe Norihito
Department Of Internal Medicine School Of Medicine Keio University
-
MATSUZAKI Shohei
Digestive and Liver Disease Center, Tokai University Tokyo Hospital
-
MATSUZAKI Shohei
Department of Internal Medicine III, Tokai University School of Medicine
-
Matsuzaki S
Digestive And Liver Disease Center Tokai University Tokyo Hospital
-
Matsuzaki S
Department Of Internal Medicine Tokai University School Of Medicine
-
Matsuzaki Shohei
Department Of Medicine (gastroenterology) Tokai University School Of Medicine
-
Matsuzaki Shohei
Department Of Gastroenterology I Tokai University School Of Medicine
-
Matsuzaki Shohei
Division Of Gastroenterology Department Of Internal Medicine Tokai University School Of Medicine
-
OGASAWARA Fusao
Department of Internal Medicine, Tokai University School of Medicine
-
HARUKI Yasuo
Department of Medical Informatics, Tokai University School of Medicine
-
Haruki Yasuo
Department Of Anatomy School Of Medicine Tokai University
-
Watanabe Norihito
Division Of Gastroenterology Department Of Internal Medicine Tokai University School Of Medicine
-
Matsuzaki Shouji
Department Of Urology Tokai University School Of Medicine
-
Ogasawara Fusao
Department Of Internal Medicine Tokai University School Of Medicine
-
Haruki Y
Department Of Medical Informatics Tokai University School Of Medicine
-
Shiraishi Koichi
Department Of Internal Medicine Tokai University School Of Medicine
-
Shiraishi Koichi
Department Of Applied Physics Fukuoka University
関連論文
- Data of Project on Atmospheric Circulation and Material Cycle in the Antarctic, Part 3. Backscattering Properties of Tropospheric Clouds and Aerosols Observed by a Lidar at Dome Fuji Station in 1997
- Lidar Observations of Polar Stratospheric Clouds over Ny-Aalesund in the Winters of 1994/95-1996/97: Impact of the Temperature and the Temperature History on the PSC Structure
- 1. Determination of the Mixing State of PSC Particles(The Mixing State of Polar Stratospheric Cloud Particles in "Sandwich Structure" Observed by Lidar)
- LIDAR OBSERVATION ABOVE SVALBARD, NORWAY IN THE WINTER OF 1996/97 : Characteristics of Backscattering Ratio and Depolarization Ratio of PSC Particles
- LARGE SIZE LIQUID PSC PARTICLES OBSERVED OVER NY-ALESUMD
- LIDAR OBSERVATIONS ABOVE NY-ALESUND, SVALBARD, NORWAY DURING WINTER 1995/96
- Lidar observed polar stratospheric clouds over Svalbard in mid-December 1994 (scientific paper)
- Polar vortex meandering and stratospheric aerosol distribution: Lidar measurements at Fairbanks, Alaska (scientific paper)
- Antiphospholipid Antibodies in Systemic Lupus Erythematosus
- Serial Monitoring of Basal Metabolic Rate for Therapeutic Evaluation in an Isaacs Syndrome Patient with Chronic Fluctuating Symptoms
- Current status of ectopic varices in Japan : Results of a survey by the Japan Society for Portal Hypertension
- Study on Causes and Ratio of the Liver Function Abnormalities in General Health Check-up
- Eight-week oral administration of meloxicam, a non-steroidal anti-inflammatory drug, prevents dose reduction of pegylated interferon α-2a in the treatment of chronic hepatitis C
- An endothelin A receptor antagonist induces dilatation of sinusoidal endothelial fenestrae : implications for endothelin-1 in hepatic microcirculation
- Increases Over the Past 10 Years in Fatty Liver, Non-alcoholic Fatty Liver and Suspicious Non-alcoholic Steatohepatitis as Seen in Ultrasound Examinations Attending General Health Check-ups
- Increase in the prevalence of fatty liver in Japan over the past 12 years : analysis of clinical background
- Immunohistochemical studies on the expression of P-glycoprotein and p53 in relation to histological differentiation and cell proliferation in hepatocellular carcinoma
- The Serum Soluble HLA-DR Antigens as a Predictive Marker of the Response to Interferon-α Treatment in Patients with Chronic Hepatitis C
- Serum concentrations of soluble HLA-class I and CD8 forms in patients with viral hepatic disorders
- The changes of serum soluble HLA-class I and CD8 concentrations during interferon treatment of chronic hepatitis C patients
- Development of quantitative neuropsychological tests for diagnosis of subclinical hepatic encephalopathy in liver cirrhosis patients and establishment of diagnostic criteria-multicenter collaborative study in Japanese
- Hemophagocytic syndrome in ileum-origin B-cell lymphoma
- Microcirculatory Disturbance of the Liver : an Important Background for Oxidative Stress in Liver Disease(The 4th Joint Symposium between Tokai University School of Medicine and Semmelweis University School of Medicine 7-9, June, 1993, Budapest)
- DEMONSTRATION OF THE LOCALIZATION OF MUSCARINIC ACETYLCHOLINE RECEPTORS IN THE GASTRIC MUCOSA : LIGHT AND ELECTRON MICROSCOPIC AUTORADIOGRAPHIC STUDIES USING ^3H-QUINUCLIDINYL BENZILATE
- Platelet Activation in Patients with Alcoholic Liver Disease
- Follow-up of Clinical Efficacy of Iontophoresis Therapy for Postherpetic Neuralgia (PHN)
- SEQUENTIAL ANALYSIS OF RECURRENT CALCIUM CALCULI BY INFRARED SPECTROSCOPY
- Treatment of Bilateral Urolithiasis
- Platelet Activation in Patients with Chronic Hepatitis C
- Focal Fatty Infiltrations in Chronic Hepatic Porphyria Without Skin Lesions
- Treatments of Generalized Pustular Psoriasis : A Multicenter Study in Japan
- Initiation, Persistence, and Cessation of the Series of Intracellular Ca2+ Responses during Fertilization of Bovine Eggs
- Urolithiasis in Geriatric Patients
- Urinary Citrate in Kidney Stone Disease
- Efficacy of a long-term follow-up of urolithiasis patients at so-called stone clinic
- A Newly Discovered Effect of Conjugated Linoleic Acid : Damage to the Hatchability of Fowl Eggs
- A Newly Discovered Effect of Conjugated Linoleic Acid : Damage to the Hatchability of Fowl Eggs
- Discrimination of the mixed state in PSCs by the means of combined lidar and OPC observations
- Variations of Volcanic Aerosols Observed in Fukuoka-A Comparison of Mt. El Chichon and Mt. Pinatubo Events-
- Seasonal Variation of Pinatubo Volcanic Aerosols in the Stratosphere Observed by Lidar in Fukuoka
- Abnormality of energy metabolism in the skeletal muscle of patients with Liver Cirrhosis and changes under administration of Glucose and Branched-Chain Amino Acids
- Re-growth of residual stone fragments after extracorporeal shock-wave lithotripsy (ESWL)
- Initiation, Persistence, and Cessation of the Series of Intracellular Ca^ Responses during Fertilization of Bovine Eggs
- Effect of Ovarian Steroids on Uptake of Radioactive Amino Acids by Brain Tissues
- Progestin Receptors in Ovaries of 4-day Cycling Rats. : An Autoradiographic Study
- Estrogen Receptor in the "Non-lymphocytes" in the Thymus of the Ovariectomized Rat
- Lifestyle and Colorectal Cancer : A Case-control Study
- The Presence of An Estrogen Receptor in The Castrated Mouse Thymus
- In Vivo Effect of Sex Steroids on Uptake of ^3H-leucine by Female Mouse Brain
- In Vivo Effect of Progesterone on Protein Synthesis in Female Ovariectomized Rat Hypothalamus
- Is Interest in Art Effective in Health-Related Quality of Life? : Results of a Cross-Sectional Survey on Lifestyle and Health Promotion
- Application of telepsychiatry : A preliminary study
- Effect of Progesterone and FSH on Testes of Immature Chickens
- Progestin Receptors in Testes from Various Animal Species
- Estrogen Receptor in Rat Thymus Cytosol
- Specific Progestin Binding in Vitro by Anterior Pituitary and Brain Tissues of Male Rats
- Cytoplasmic Estrogen Receptor in Castrated Rat Thymus
- Progestin Binding by Brain Cell Nuclei of Ovariectomized Estrogen-Primed Rats
- Progesterone Binding by Cell Nuclei of the Hypothalamus of Estrogen-primed Ovariectomized Rats
- Accumulation and Binding of 3H-Estradio1-17β by Lymphoid Tissues of Castrated Mice
- Existence and Properties of Progesterone-binding Proteins in Female Rat Hypothalamus
- Uptake and Binding of ^3H-testosterone by Lymphoid Tissues of Castrated Mice
- Comparative analysis of measurements of stratospheric aerosol by lidar and aerosol sonde above Ny-Alesund in the winter of 1995 [Comparative analysis of lidar and OPC observations]
- Estrogen Receptor in the Thymus of the Castrated Mice
- Further Evidence of the Presence of Progesterone-Binding Proteins in Female Rat Hypothalamus
- Apheresis for Fulminant Hepatitis Effects on Clinical Complications and Prognosis(Symposium 3: Apheresis in the Treatment of Liver Disease)
- Weight-based high- and low-dose ribavirin in combination with peginterferon α-2b therapy for genotype 2 chronic hepatitis C : A randomized trial