Abnormality of energy metabolism in the skeletal muscle of patients with Liver Cirrhosis and changes under administration of Glucose and Branched-Chain Amino Acids
スポンサーリンク
概要
- 論文の詳細を見る
We assessed changes in skeletal muscle energy metabolism by 31P-magnetic resonance spectroscopy (31P-MRS) and oxygen supply by near-infrared spectroscopy (NIR), after exercise and after administration of glucose and a branched-chain amino acids (BCAA), in healthy volunteers and patients with liver cirrhosis. As for the patients with liver cirrhosis, 4 were classified in Child-Pugh Grade A and the other 4 in Grade B. In patients with liver cirrhosis, the intramuscular pH and PCr index (PCr/PCr+Pi) were lower than in healthy subjects after exercise in the fasting state; the ⊿pH and ⊿PCr index were statistically siginificant (p<0.05), indicating a disorder of aerobic metabolism. NIR revealed normality with oxygen supply and suggested a decreased oxygen utilization efficiency; that is, failure of the TCA cycle. The ⊿pH improved slightly after the administration of glucose alone, while it was definitely low (p<0.05) after co-administration of glucose and BCAA, which acts directly on the TCA cycle, indicating improvement of skeletal muscle energy metabolism.
著者
-
Shiraishi Koichi
Department of Applied Physics, Fukuoka University
-
HAIDA Munetaka
Departments of Neurology Tokai University School of Medicine
-
Haida Munetaka
Department Of Medical Education & Informatics Tokai University School Of Medicine
-
Haida Munetaka
Department Of Internal Medicine School Of Medicine Tokai University
-
MATSUZAKI Shohei
Department of Internal Medicine III, Tokai University School of Medicine
-
Doi Jun
Department of Agricultural Chemistry, University of Osaka Prefecture
-
Matsuzaki Shohei
Department Of Gastroenterology Tokai University School Of Medicine
-
Matsuzaki Shohei
Department Of Gastroenterology I Tokai University School Of Medicine
-
Doi Jun
Department Of Gastroenterology Tokai University School Of Medicine
-
Shiraishi Koichi
Department Of Gastroenterology Tokai University School Of Medicine
-
Shiraishi Koichi
Department Of Applied Physics Fukuoka University
関連論文
- Data of Project on Atmospheric Circulation and Material Cycle in the Antarctic, Part 3. Backscattering Properties of Tropospheric Clouds and Aerosols Observed by a Lidar at Dome Fuji Station in 1997
- Lidar Observations of Polar Stratospheric Clouds over Ny-Aalesund in the Winters of 1994/95-1996/97: Impact of the Temperature and the Temperature History on the PSC Structure
- 1. Determination of the Mixing State of PSC Particles(The Mixing State of Polar Stratospheric Cloud Particles in "Sandwich Structure" Observed by Lidar)
- LIDAR OBSERVATION ABOVE SVALBARD, NORWAY IN THE WINTER OF 1996/97 : Characteristics of Backscattering Ratio and Depolarization Ratio of PSC Particles
- LARGE SIZE LIQUID PSC PARTICLES OBSERVED OVER NY-ALESUMD
- LIDAR OBSERVATIONS ABOVE NY-ALESUND, SVALBARD, NORWAY DURING WINTER 1995/96
- Lidar observed polar stratospheric clouds over Svalbard in mid-December 1994 (scientific paper)
- Polar vortex meandering and stratospheric aerosol distribution: Lidar measurements at Fairbanks, Alaska (scientific paper)
- A case of systemic lupus erythematosus with various central and pripheral neurological disorders developed with motor paralytic bladder as a major manifestation
- The changes of serum soluble HLA-class I and CD8 concentrations during interferon treatment of chronic hepatitis C patients
- Structure of a New Antibiotic Oxaspirol A
- Development of quantitative neuropsychological tests for diagnosis of subclinical hepatic encephalopathy in liver cirrhosis patients and establishment of diagnostic criteria-multicenter collaborative study in Japanese
- Hemophagocytic syndrome in ileum-origin B-cell lymphoma
- Microcirculatory Disturbance of the Liver : an Important Background for Oxidative Stress in Liver Disease(The 4th Joint Symposium between Tokai University School of Medicine and Semmelweis University School of Medicine 7-9, June, 1993, Budapest)
- The Magnetic Properties of Ferroelectric and Ferromagnetic Ni-Cl Boracite at Low Temperature
- Platelet Activation in Patients with Alcoholic Liver Disease
- Platelet Activation in Patients with Obstructive Sleep Apnea Syndrome and Effects of Nasal-Continuous Positive Airway Pressure
- Platelet Activation in Patients with Chronic Hepatitis C
- Initiation, Persistence, and Cessation of the Series of Intracellular Ca2+ Responses during Fertilization of Bovine Eggs
- Discrimination of the mixed state in PSCs by the means of combined lidar and OPC observations
- Variations of Volcanic Aerosols Observed in Fukuoka-A Comparison of Mt. El Chichon and Mt. Pinatubo Events-
- Seasonal Variation of Pinatubo Volcanic Aerosols in the Stratosphere Observed by Lidar in Fukuoka
- Abnormality of energy metabolism in the skeletal muscle of patients with Liver Cirrhosis and changes under administration of Glucose and Branched-Chain Amino Acids
- Initiation, Persistence, and Cessation of the Series of Intracellular Ca^ Responses during Fertilization of Bovine Eggs
- Detection of Stable Radicals in Malignant Ascites and Pleural Effusion by Electron Spin Resonance
- Anomalous Weak Ferromagnetism in Ferroelectric CuCl Boracite
- Paramagnetic Torque an Crystallographic Domain Distributions in an Iron Iodine Boracite Single Crystal
- Interpretation of Pathophysiology by Laboratory Data (3) A Consultation Program Based on Clinical Laboratory Data
- Differentiation of Lung Cancer and Radiation Fibrosis Using Magnetic Resonance Images : A Case Study
- Deoxygenated Hemoglobin/Myoglobin Kinetics of Forearm Muscles from Rest to Exercise in Patients with Chronic Obstructive Pulmonary Disease
- Dependence of Transverse Relaxation Time T_2 of Biologic Tissues on the Interpulse Delay Time in Carr-Purcell-Meiboom-Gill (CPMG) Measurements
- Dielectric Study on Tissue Water by a Time Domain Reflectometry Method
- Quantification of Water Content in Biological Tissues by Proton Nuclear Magnetic Resonance
- Magnetic Torque and Weak Ferromagnetism in KFeF_3 Single Crystals
- Comparative analysis of measurements of stratospheric aerosol by lidar and aerosol sonde above Ny-Alesund in the winter of 1995 [Comparative analysis of lidar and OPC observations]
- Apheresis for Fulminant Hepatitis Effects on Clinical Complications and Prognosis(Symposium 3: Apheresis in the Treatment of Liver Disease)