Effect of Ovarian Steroids on Uptake of Radioactive Amino Acids by Brain Tissues
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概要
- 論文の詳細を見る
Effects of two major ovarian hormones, estrogen (E) and progesterone (P), on the uptake of amino acids by the brain nuclei of ovariectomized mice were examined. They were divided into four groups : (1) oil controls, (2) P-treated, (3) estradiol benzoate (E_2B)-treated, and (4) E_2B-primed P-treated mice. Two hr after the last hormonal treatment they were given a single s. c. injection of a mixture of ^3H-leucine and ^3H-methionine, and then sacrificed 2 hr later. Intensity of the uptake of radioactivity was measured on autoradiograms of the stained tissue sections. Group 1 showed a relatively high uptake of radioactivity by the SO, PV and SPH, compared with that by the remaining brain cells. Group 2 had a slight enhancement of the uptake by the VM, SPH and CC, compared with that in group 1. Group 3 showed a significant enhancement of the uptake by most of the preoptico-hypothalamic nuclei except for the VM, DM and PM, compared with that in group 1. Group 4 had slightly enhanced uptake by the POM, POL, SCH, SO, PV, VM, ARC, SPH and CC, compared with that in group 1. E-priming affected the uptake; it enhanced the uptake by the VM and SPH, and inhibited it by the PVA, AH, LH and CC. Uptake by the PM and EC remained unchanged in all groups. The present results suggest that two major steroids, E and P, influence protein synthesis in most of the brain regions including the preoptic and hypothalamic areas. It is also suggested that response of the preoptico-hypothalamic nuclei to P for protein synthesis is affected by E-priming.
- 東海大学の論文
著者
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SAKABE KOU
Department of Public Health and Molecular Toxicology, Kitasato University School of Pharmaceutical S
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HARUKI Yasuo
Department of Medical Informatics, Tokai University School of Medicine
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Haruki Yasuo
Department Of Anatomy School Of Medicine Tokai University
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Sakabe Kou
Department Of Anatomy School Of Medicine Tokai University
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Sakabe Kou
Department Of Anatomy And Cellular Biology Tokai University School Of Medicine
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Nakano Mayumi
Department Of Bioresource Science Obihiro University Of Agriculture And Veterinaty Medicine
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SEIKI Kanji
Department of Anatomy, School of Medicine, Tokai University
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Seiki Kanji
Department Of Anatomy School Of Medicine Tokai University
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Seiki Kanji
Department Of Analomy School Of Medicine Tokai University
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FUJII Hideko
Department of Anatomy, School of Medicine, Tokai University
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Fujii Hideko
Department Of Anatomy School Of Medicine Tokai University
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Nakano Mayumi
Department Of Anatomy School Of Medicine Tokai University
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