The Serum Soluble HLA-DR Antigens as a Predictive Marker of the Response to Interferon-α Treatment in Patients with Chronic Hepatitis C

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概要

• 論文の詳細を見る

• The serum concentrations of soluble HLA-DR antigens (sDR) were monitored in 40 patients with chronic hepatitis C (CHC) who received interferon treatment. The expression of HLA-class II antigens in liver tissues was also studied by immunohistochemistry. The sDR levels in patients with chronic hepatitis C were significantly higher than those in healthy subjects (416±236 [mean±S.D.] ng/ml vs. 286±163 ng/ml) (P<0.05). There was no correlation between the sDR levels and serum alanine aminotransferase levels, suggesting that sDR do not reflect the extent of liver necrosis. Although there was no difference in pretreatment sDR levels between interferon complete responders and non-responders, sDR significantly declined in complete responders, while they did not in non-responders. The hepatic expression of HLA-DR antigens was observed in dendritic cells, lymphocytes and Kupffer cells in portal area, while in Kupffer cells and endothelial cells in central acinus. These expression significantly decreased in complete responders. From these results, sDR, reflecting the hepatic expression of HLA-DR antigens, could be a predictive marker of response to inteferon treatment.

• 東海大学の論文

著者

• Watanabe Norihito

  Department Of Internal Medicine Tokai University School Of Medicine

• Hagihara Masao

  Department Of Hematology And Oncology Tokai University School Of Medicine

• MATSUZAKI Shohei

  Digestive and Liver Disease Center, Tokai University Tokyo Hospital

• KAGAWA Tatehiro

  Department of Gastroenterology, Tokai University School of Medicine

• WATANABE NORIHITO

  Division of Gastroenterology, Department of Internal Medicine, Tokai University School of Medicine

• KAGAWA TATEHIRO

  Division of Gastroenterology, Department of Internal Medicine, Tokai University School of Medicine

• MATSUZAKI SHOHEI

  Division of Gastroenterology, Department of Internal Medicine, Tokai University School of Medicine

• HOSOI Katsumi

  Division of Gastroenterology, Department of Internal Medicine, Tokai University School of Medicine

• HAGIHARA Masao

  Division of Hematology and Rheumatology, Department of Internal Medicine, Tokai University School of

• Matsuzaki S

  Digestive And Liver Disease Center Tokai University Tokyo Hospital

• Matsuzaki S

  Department Of Internal Medicine Tokai University School Of Medicine

• Matsuzaki Shohei

  Department Of Medicine (gastroenterology) Tokai University School Of Medicine

• Matsuzaki Shohei

  Division Of Gastroenterology Department Of Internal Medicine Tokai University School Of Medicine

• Watanabe Norihito

  Division Of Gastroenterology Department Of Internal Medicine Tokai University School Of Medicine

• Matsuzaki Shouji

  Department Of Urology Tokai University School Of Medicine

• Hosoi Katsumi

  Division Of Gastroenterology Department Of Internal Medicine Tokai University School Of Medicine

• Kagawa Tatehiro

  Department Of Gastroenterology Tokai University School Of Medicine

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