Comparison of Soluble and Membrane Bound HLA-Class I and DR Levels in Umbilical Cord Blood and Adult Peripheral Blood
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概要
- 論文の詳細を見る
HLAs are membrane bound (membrane HLA=mHLA) or secreted as soluble forms (soluble HLA=sHLA) in plasma or serum. Umbilical cord blood (UCB) mHLA, from mononuclear cells (MNCs), and sHLA were quantified by flow cytometry and enzyme linked immunosorbant assay (ELISA), respectively, and compared to levels of MNC-mHLA and sHLA in adult peripheral blood (PB). The mean fluorescence intensity (MFI) of mHLA-I was 3-fold lower in UCB-MNCs than in adult PB-MNCs, however, due to higher cell numbers in UCB, total mHLA-I quantities per ml of blood were not different in UCB and adult PB. In addition, sHLA-I in UCB was significantly lower than in adult PB. The MFI of mHLA-DR from UCB-MNCs was significantly higher than the MFI of mHLA-DR in adult PB-MNCs, and the total mDR quantity (per ml of blood) in UCB was 3-fold higher than in adult PB. sHLA-DR concentrations, however, were equivalent in UCB and adult PB. These findings indicate that fetal tissue or cells might excrete smaller quantities of both sHLA-I and sDR antigens than adult tissues or cells. Alternatively, fetal sHLA antigens might be unstable and degradated compared to those of adult.
- 東海大学の論文
著者
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KATO Shunichi
Department of Cell Transplantation and Regenerative Medicine, Tokai University School of Medicine
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HOTTA Tomomitsu
Department of Hematology and Oncology, Tokai University School of Medicine
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Hotta Tomomitsu
国立がんセンター中央病院 血液内科
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Hotta T
National Hospital Organization Nagoya Medical Center
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Hata Tomoko
Nagasaki University
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Hata Tomoko
Department Of Hematology Molecular Medicine Unit Atomic Bomb Disease Institute Nagasaki University G
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Kato Shunichi
Cell Transplantation And Regenerative Medicine Tokai University School Of Medicine
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Kato Shunichi
Department Of Cell Transplantation And Regenerative Medicine Tokai University School Of Medicine
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Higuchi Ayako
Cell Transplantation And Regenerative Medicine Tokai University School Of Medicine
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Hagihara Masao
Department Of Hematology And Oncology Tokai University School Of Medicine
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Kato Shunichi
Department Of Cell Transplantation And Regenerative Medicine Tokai University
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Hotta Tomomitsu
Department Of Hematology And Molecular Medicine Unit Atomic Bomb Disease Institute Nagasaki Universi
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Hotta T
Tokai Univ. School Of Medicine Kanagawa
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Tsumuraya Naoko
Department of Cardiology, Tokai University Hospital
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GANSUVD Balgansuren
Department of Hematology and Oncology, Tokai University School of Medicine
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Tsumuraya Naoko
Department Of Cardiology Tokai University Hospital
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Tsumuraya Naoko
Department Of Hematology And Oncology Tokai University School Of Medicine
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Hotta Tomomitsu
Nagoya Medical Center Nagoya Jpn
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Gansuvd Balgansuren
Department Of Hematology And Oncology Tokai University School Of Medicine
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Hotta Tomomitsu
Department Of Hematology Nagasaki University Hospital
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