Expression of myeloperoxidase and gene mutations in AML patients with normal karyotype: double CEBPA mutations are associated with high percentage of MPO positivity in leukemic blasts.
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概要
- 論文の詳細を見る
The percentage of myeloperoxidase (MPO)-positive blast cells is a simple and highly significant prognostic factor in AML patients. It has been reported that the high MPO group (MPO-H), in which >50% of blasts are MPO activity positive, is associated with favorable karyotypes, while the low MPO group (≤50% of blasts are MPO activity positive, MPO-L) is associated with adverse karyotypes. The MPO-H group shows better survival even when restricted to patients belonging to the intermediate chromosomal risk group or those with a normal karyotype. It has recently been shown that genotypes defined by the mutational status of NPM1, FLT3, and CEBPA are associated with treatment outcome in patients with cytogenetically normal AML. In this study, we aimed to evaluate the relationship between MPO positivity and gene mutations found in normal karyotypes. Sixty AML patients with normal karyotypes were included in this study. Blast cell MPO positivity was assessed in bone marrow smears stained for MPO. Associated genetic lesions (the NPM1, FLT3-ITD, and CEBPA mutations) were studied using nucleotide sequencing. Thirty-two patients were in the MPO-L group, and 28 patients in the MPO-H group. FLT3-ITD was found in 11 patients (18.3%), NPM1 mutations were found in 19 patients (31.7%), and CEBPA mutations were found in 11 patients (18.3%). In patients with CEBPA mutations, the carrying two simultaneous mutations (CEBPA (double-mut)) was associated with high MPO expression, while the mutant NPM1 without FLT3-ITD genotype was not associated with MPO activity. Both higher MPO expression and the CEBPA (double-mut) genotype appeared to be associated with improved overall survival after intensive chemotherapy. Further studies are required to determine the importance of blast MPO activity as a prognostic factor, especially in CEBPA wild-type patients with a normal karyotype.
- 2011-07-01
著者
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谷脇 雅文
高知工科大学工学部
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三木 義男
癌研ゲノムセンター
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Morishima Y
Department Of Hematology Kinki University School Of Medicine
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Moriwaki Yuji
長崎大学大学院医歯薬学総合研究科附属原爆後障害医療研究施設 分子治療研究分野
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TSUSHIMA Hideki
Nagasaki CML Study Group
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YOSHIDA Shinichiro
Nagasaki CML Study Group
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TAWARA Masayuki
Nagasaki CML Study Group
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KURIYAMA Kazutaka
Nagasaki CML Study Group
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Mano Hiroyuki
Division of functional genomics, Jichi Medical University
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三木 義男
東京医歯大 難治疾患研 疾患医科学研究系分子遺伝分野
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Takahashi Masatomo
Division Of Hematology And Oncology Department Of Internal Medicine St. Marianna University School O
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Takahashi Masatomo
聖マリアンナ医科大学 血液・腫瘍内科
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Matsushima Takafumi
Department Of Hematology St. Marianna University School Of Medicine
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谷脇 雅文
Department Of Environmental Systems Engineering Kochi University Of Technology
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Hotta Tomomitsu
国立がんセンター中央病院 血液内科
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Hotta Tomomitsu
東海大学 医学研究科血液腫瘍内科
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Taniwaki Masafumi
国立がんセンター中央病院 血液内科
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Taniwaki Masafumi
Division Of Hematology And Oncology Department Of Medicine Kyoto Prefectural University Of Medicine
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Tsuchida Masahiro
産業医科大学 小児科学
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Tanimoto M
Blood Transfusion Division Department Of Internal Medicine Ii Okayama University Graduate School Of
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Tanimoto Mitsune
Okayama Univ. Hospital Okayama Jpn
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Tanimoto Mitsune
岡山大学 医歯総研究 第2内科
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Kitamura Kunio
名古屋大学 医学系研究科血液・腫瘍内科学
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Iwanaga Masako
Nagasaki Univ. Graduate School Of Biomedical Sci. Nagasaki Jpn
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Iwanaga Masako
Department Of Hematology And Molecular Medicine Unit Atomic Bomb Disease Institute Nagasaki Universi
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Iwanaga Masako
Department Of Hematology And Molecular Medicine Nagasaki University Graduate School Of Biomedical Sc
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Kuriyama K
Blood Immunology Laboratory School Of Health Sciences Faculty Of Medicine And University Hospital Un
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Murakami Hirokazu
School Of Health Sciences Faculty Of Medicine Gunma University
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Murakami Hirokazu
Third Department Of Internal Medicine Gunma University School Of Medicine
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Tomonaga Masao
Department Of Hematology And Molecular Medicine Unit Atomic Bomb Disease Institute Nagasaki Universi
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Hotta T
National Hospital Organization Nagoya Medical Center
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Hotta Tomomitsu
Department Of Hematology Molecular Medicine Unit Atomic Disease Institute Nagasaki University Gradua
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Hata Tomoko
Nagasaki University
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Hata Tomoko
Department Of Hematology Molecular Medicine Unit Atomic Bomb Disease Institute Nagasaki University G
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Taniwaki M
Celgene Kk
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Tanimoto Mitsune
名古屋大学 第1内科
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Matsumoto-mishima Yuko
癌研究会癌化学療法センター 臨床研究部
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Imanishi Daisuke
Department Of Hematology And Molecular Medicine Unit Atomic Bomb Disease Institute Nagasaki Universi
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TSUSHIMA Hideki
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki Univer
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YOSHIDA Shinichiro
Department of Internal Medicine, Nagasaki Medical Center
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HONDA Miyuki
Nagasaki CML Study Group
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Matsuno Y
Department Of Surgical Pathology Hokkaido University Hospital
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Matsuno Yoshihiro
Department Of Chemotherapy Tokyo Metropolitan Cancer And Infectious Diseases Center Komagome Hospita
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Tomonaga Masao
Department Of Hematology Atomic Bomb Disease Institute Nagasaki University School Of Medicine
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Taniwaki Masafumi
Third Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Taniwaki Masafumi
Department Of Molecular Hematology And Oncology Kyoto Prefectural University Of Medicine Graduate Sc
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Morishima Yasuo
Department Of Hematology And Cell Therapy Aichi Cancer Center Central Hospital
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Tomonaga Masao
Department Of Hematology Molecular Medicine Unit Atomic Disease Institute Nagasaki University Gradua
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Tomonaga Masao
Department Of Hematology Molecular Medicine Unit Atomic Bomb Disease Institute Nagasaki University
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Matsuo Yuji
Department Of Hematology And Molecular Medicine Unit Atomic Bomb Disease Institute Nagasaki Universi
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Fukushima Takuya
Department Of Hematology And Molecular Medicine Unit Atomic Bomb Disease Institute Nagasaki Universi
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Morishima Yasuo
Department Of Hematology And Chemotherapy
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Murai Yoshiro
Department Of Hematology Tama Hokubu Medical Center
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Taniwaki Masafumi
Department Of Hematology/oncology Kyoto Prefectural University Of Medicine
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Hata Tomoko
Department Of Hematology And Molecular Medicine Unit Atomic Bomb Disease Institute Nagasaki Universi
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Masaki Y
Department Of Hematology And Immunology Kanazawa Medical University
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Morishita Yoshihisa
Department Of Hematology And Oncology Ja Aichi Showa Hospital
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Morita Yasuyoshi
Kinki Univ. School Of Medicine Osaka Jpn
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Matsumoto Yosuke
Department Of Molecular Hematology And Oncology Graduate School Of Medical Science Kyoto Prefectural
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Miyazaki Yasushi
Department Of Hematology And Molecular Medicine Unit Atomic Bomb Disease Institute Nagasaki Universi
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Morishita Yasuyuki
Department Of Pathology And Oncology Institute Of Medical Science University Of Tokyo
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Matsuyama Toshifumi
Department Of Molecular Microbiology And Immunology Nagasaki University Graduate School Of Medicine
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Imaizumi Yoshitaka
Department Of Hematology And Molecular Medicine Unit Atomic Bomb Disease Institute Nagasaki Universi
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Tomonaga Masao
Department Of Haematology Atomic Bomb Disease Institute Nafasaki University School Of Medicine
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Mano Hiroyuki
Division Of Cardiovascular Medicine Department Of Medicine Jichi Medical School
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Yasukawa Masaki
Department Of Bioregulatory Medicine Ehime University
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Taguchi Jun
Department Of Hematology And Molecular Medicine Unit Atomic Bomb Disease Institute Nagasaki Universi
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Taguchi Jun
Department Of Hematology Kanagawa Cancer Center
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Itonaga Hidehiro
Department Of Hematology And Molecular Medicine Unit Atomic Bomb Disease Institute Nagasaki Universi
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Miki Yoshio
Department Of Human Genome Analysis Cancer Chemotherapy Center Japanese Foundation For Cancer Resear
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Tanimoto Mitsune
Okayama Univ. Graduate School Of Medicine Okayama Jpn
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Tominaga Shinya
Department Of Hematology And Molecular Medicine Unit Atomic Bomb Disease Institute Nagasaki Universi
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Hotta Tomomitsu
Nagoya Medical Center Nagoya Jpn
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Morishima Yasuo
Department Of Pathology And Oncology Institute Of Medical Science University Of Tokyo
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Fukushima Toshihiro
Department Of Hematology And Immunology Kanazawa Medical University
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Ando Koji
Department Of Hematology And Molecular Medicine Unit Atomic Bomb Disease Institute Nagasaki Universi
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Tabata Masahiro
The Department Of Internal Medicine Ii Okayama University Medical School
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Imanishi Daisuke
Department Of Hematology Molecular Medicine Unit Atomic Bomb Disease Institute Nagasaki University G
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Ando Koji
Department Of Applied Chemistry Faculty Of Science And Technology Keio University
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Takabayashi Maki
Department Of Internal Medicine And Clinical Immunology Yokohama City University Graduate School Of
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TOMINAGA SATO
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki Univer
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MORIUCHI Yukiyoshi
Division of Hematology, Sasebo City General Hospital
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KURIYAMA Kazutaka
School of Health Sciences, University of the Ryukyus
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Yoshida Shinichiro
Department Of Internal Medicine Nagasaki National Medical Center
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Kuriyama Kazutaka
School Of Health Sciences University Of The Ryukyus
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Fukushima Takuya
Department Of Hematology Nagasaki University Hospital
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Mikami Yuzuru
Department Of Hematology And Cell Therapy Aichi Cancer Center Hospital
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Tominaga-Sato Shinya
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences
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TAGUCHI Jun
Department of Chemistry and Materials Science Tokyo Institute of Technology
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IMAIZUMI Yoshitaka
Department of Hematology, Nagasaki University Hospital
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IMAIZUMI Yoshitaka
Department of Basic Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan
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YOSHIDA Shinichiro
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute Nagasaki University Graduate School of Biosciences
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