TAWARA Masayuki | Nagasaki CML Study Group
スポンサーリンク
概要
関連著者
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TAWARA Masayuki
Nagasaki CML Study Group
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谷脇 雅文
高知工科大学工学部
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Moriwaki Yuji
長崎大学大学院医歯薬学総合研究科附属原爆後障害医療研究施設 分子治療研究分野
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Morishima Y
Department Of Hematology Kinki University School Of Medicine
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三木 義男
癌研ゲノムセンター
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Tobinai K
Hematology And Stem Cell Transplantation Divisions National Cancer Center Hospital
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Maeda S
Center For Hematopoietic Disorders Ohta Nishinouchi Hospital The Ohta Foundation
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Seto M
Department Of Hematology And Chemotherapy
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Miyazaki Yoshitsugu
長崎大学 第二内科
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Seto Masao
愛知県がんセンター研究所 分子腫瘍学部
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ISHIGATSUBO Yoshiaki
Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of
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OHNO Ryuzo
Aichi Cancer Center
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Seto Masao
東京大学医学部附属病院 無菌治療部
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Tobinai Kensei
国立がんセンター中央病院 血液内科グループ
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Tobinai Kensei
東海大学 医学部
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SUGIYAMA Haruo
Departments of Clinical Laboratory Science
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MIYAZAKI Yasushi
Department of Hematology, Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki Universit
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Kishimoto Yuji
The First Department Of Internal Medicine Kansai Medical University
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KURIYAMA Kazutaka
Nagasaki CML Study Group
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UEDA Atsuhisa
Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of
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Matsuse Michiko
Graduate School Of Biomedical Sciences Nagasaki Univ.
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Yamashita S
Department Of Molecular Medicine Atomic Bomb Disease Institute Nagasaki University Graduate School O
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TOBINAI Kensei
Hematology and Stem Cell Transplantation Divisions, National Cancer Center Hospital
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OGURA Michinori
Department of Hematology and Cell Therapy, Aichi Cancer Center
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Katayama Y
Division Of Hematology Saitama Medical Center Jichi Medical University
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TOMONAGA Masao
Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine
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Tsuboi Naoya
Department Of Hematology And Oncology Nagoya University Graduate School Of Medicine
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TSUSHIMA Hideki
Nagasaki CML Study Group
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OKAMOTO Shinichiro
Division of Hematology, Department of Medicine, Keio University School of Medicine
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IMANISHI Daisuke
Department of Hematology, Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki Universit
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YAGASAKI Fumiharu
Department of Hematology, Saitama Medical University Hospital
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NAOE Tomoki
Department of Hematology and Oncology, Nagoya University Graduate School of Medicine
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永井 正
自治医科大学内科学講座血液学部門
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坂本 弘明
Department of Internal Medicine II, Fukushima Medical University, School of Medicine
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WATANABE Takashi
Hematology and Stem Cell Transplantation Divisions, National Cancer Center Hospital
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ITOH Kuniaki
Division of Oncology and Hematology, National Cancer Center Hospital East
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TSUKASAKI Kunihiro
Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine
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永井 正
自治医科大学 内科学講座血液学部門
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Nakamura S
Department Of Pathology Nagoya University School Of Medicine
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Nakamura Shigeo
国立がんセンター中央病院 血液内科
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Nakamura Shigeo
群馬県立がんセンター 病理検査
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岡田 昌也
兵庫医科大学総合内科学血液・腫瘍科
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斉藤 広信
福島県立医科大学 医学部内科学第二講座
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HATA Tomoko
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki Univer
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INOUE Yoriko
Nagasaki CML Study Group
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KAWAGUCHI Yasuhisa
Nagasaki CML Study Group
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YOSHIDA Shinichiro
Nagasaki CML Study Group
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JINNAI Itsuro
Nagasaki CML Study Group
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Mano Hiroyuki
Division of functional genomics, Jichi Medical University
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Ando Kiyoshi
Division of Hematology and Oncology, Tokai University School of Medicine
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KANDA Yoshinobu
Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo
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MARUTA Atsuo
Department of Hematology, Kanagawa Cancer Center
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Honda Sumihisa
Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences
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Sasaki Nana
Division Of Hematology And Oncology Department Of Medicine Kyoto Prefectural University Of Medicine
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OHTAKE Shigeki
Department of Hematology, Kanazawa University Graduate School of Medical Science
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MIYAWAKI Shuichi
Division of Hematology, Saiseikai Maebashi Hospital
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OKUMURA Hirokazu
Department of Hematology, Kanazawa University Graduate School of Medical Science
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MATSUDA Shin
Center for Hematopoietic Disorders, Ohta Nishinouchi Hospital, The Ohta Foundation
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KISHIMOTO Yuji
The First Department of Internal Medicine, Kansai Medical University
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TAKAHASHI Masatomo
Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School
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ASOU Norio
Department of Hematology, Kumamoto University School of Medicine
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ANDO Kiyoshi
Department of Hematology/Oncology, Tokai University School of Medicine
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ANDO KOJI
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
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Yamaji Satoshi
Department of Cardiology, Nihon University Surugadai Hospital
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MORISHIMA Yasuo
Department of Hematology and Cell Therapy, Aichi Cancer Center
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清水 一之
名古屋市立緑市民病院内科
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MATSUO Yuzi
the Department of Laboratory Midicine
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KOBAYASHI Hiroshi
Department of Physics, Rikkyo University
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Miura S
Division Of Molecular Medicine Aichi Cancer Center Research Institute
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Fujimoto Yoshiko
京都府立大学 医学研究科血液腫瘍内科学
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Fujimoto Yoshiko
Department Of Molecular Hematology And Oncology Graduate School Of Medical Science Kyoto Prefectural
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Ogawa Daisuke
Nagasaki Cml Study Group
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SAKAI Mari
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki Univer
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MATSUO Emi
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki Univer
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MORIUCHI Yukiyoshi
Nagasaki CML Study Group
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FUKUSHIMA Takuya
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki Univer
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IMAIZUMI Yoshitaka
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki Univer
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TAGUCHI Jun
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki Univer
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IWANAGA Masako
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki Univer
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TAKASAKI Yumi
Nagasaki CML Study Group
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NAGAI Kazuhiro
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki Univer
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TSUTSUMI Chizuko
Nagasaki CML Study Group
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SAWAYAMA Yasushi
Nagasaki CML Study Group
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YAMASAKI Reishi
Nagasaki CML Study Group
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IKEDA Shuichi
Nagasaki CML Study Group
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ONIMARU Yasuyuki
Nagasaki CML Study Group
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ATOGAMI Sunao
Nagasaki CML Study Group
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JOH Tatsuro
Nagasaki CML Study Group
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YAMAMURA Masaomi
Nagasaki CML Study Group
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MATSUO Yuji
Nagasaki CML Study Group
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SODA Hisashi
Nagasaki CML Study Group
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NONAKA Hiroaki
Nagasaki CML Study Group
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KANAMORI Heiwa
Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of
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SAKAMAKI Hisashi
Department of Hematology, Tokyo Metropolitan Komagome Hospital
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MORI Takehiko
Division of Hematology, Department of Medicine, Keio University School of Medicine
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KASAI Masanobu
Department of Hematology, Nagoya Daini Red Cross Hospital
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MINE Mariko
Biostatistics Section, Nagasaki University Graduate School of Biomedical Sciences
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MINE MARIKO
Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences
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HAYASHI Yoshihiko
Research Reactor Institute, Kyoto University
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YOSHIIE Toshimasa
Research Reactor Institute, Kyoto University
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AKIYAMA Hideki
Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
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SAKAMAKI Hisashi
Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
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MORITA Yasuyoshi
Department of Hematology, Kinki University School of Medicine
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KANAMARU Akihisa
Department of Hematology, Kinki University School of Medicine
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TANIMOTO Mitsune
Blood Transfusion Division, Department of Internal Medicine II, Okayama University Graduate School o
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KURIYAMA Kazutaka
Blood Immunology Laboratory, School of Health Sciences, Faculty of Medicine and University Hospital,
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KOBAYASHI Toru
Department of Hematopoietic Pathobiology and Medical Oncology, Mie University Graduate School of Med
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IMOTO Shion
Hyogo Prefectural Red Cross Blood Center
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OHNISHI Kazunori
Third Department of Internal Medicine, Hamamatsu University School of Medicine
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KIYOI Hitoshi
Department of Hematology and Oncology, Nagoya University Graduate School of Medicine
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NAGAI Tadashi
Division of Hematology, Jichi Medical University
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OKADA Masaya
Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine
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HANDA Hiroshi
Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
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TAKEUCHI Jin
Department of Hematology and Rheumatology, Nihon University School of Medicine
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KAGEYAMA Shinichi
Department of Hematology and Oncology, Mie University Graduate School of Medicine
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MAEDA Yasuhiro
Department of Hematology, Kinki University School of Medicine
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OHNISHI Kazunori
Oncology Center, Hamamatsu University School of Medicine
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UIKE Naokuni
Department of Hematology, National Kyushu Cancer Center
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SAKAMAKI Hisashi
Division of Hematology, Tokyo Metropolitan Komagome Hospital
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EMI Nobuhiko
Department of Hematology, Fujita Health University
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MITANI Kinuko
Department of Hematology, Dokkyo University School of Medicine
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MIYAZAKI Yasushi
The Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University School of Medicine
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OGAWA Yoshiaki
Department of Hematology and Oncology, Tokai University School of Medicine
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Sao Hiroshi
Department of Hematology, Meitetsu Hospital
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KONDO Hisayoshi
Biostatics Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki Un
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Kawabata S
Second Dep. Of Internal Medicine Nagasaki Univ. School Of Medicine
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Tsukamoto Norifumi
Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
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Murakami Hirokazu
Faculty of Health Science, Gunma University School of Medicine
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NAKAO Shinji
Department of Cellular Transplantation Biology, Graduate School of Medical Sciences, Kanazawa Univer
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TANAKA Takashi
Department of Physics, Faculty of Science, Okayama University
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Yamada Y
Dep. Of Lab. Medicine Nagasaki Univ. Graduate School Of Biomedical Sciences Nagasaki Univ. Hospital
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Yamada Yasuaki
富山大学 工学部
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上平 憲
長崎大学臨床検査医学
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Yamashita S
Radiation And Environmental Health Department Of Protection Of The Human Environment World Health Or
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Sugahara Kazuyuki
長崎大学 医歯薬学総合研究科臨床検査医学講座
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Maruyama Dai
Hematology And Stem Cell Transplantation Divisions National Cancer Center Hospital
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YOKOYAMA Hiroki
Hematology and Stem Cell Transplantation Division, National Cancer Center Hospital
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NAKATA Masanobu
Division of Oncology and Hematology, National Cancer Center Hospital East
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HOTTA Tomomitsu
Department of Hematology and Oncology, Tokai University School of Medicine
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SHIINA MASAAKI
Department of Gastroenterology, Sendai National Hospital
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Yamada Y
Nagasaki Univ. Graduate School Of Biomedical Sci. Nagasaki Jpn
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TSUCHIDA Masahiro
Department of Pediatrics, Ibaraki Children's Hospital
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新田 紀子
神戸大工
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KOHGO YUTAKA
Department of Medicine, Division of Gastroenterology and Hematology/Oncology, Asahikawa Medical Coll
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Ohashi Yasuo
Department of Biostatistics/Epidemiology and Preventive Health Sciences, School of Health Sciences a
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OGAWA Daisuke
Department of Medicine and Clinical Science (Internal Medicine III), Okayama University Graduate Sch
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Kawata Eri
Division Of Hematology And Oncology Department Of Medicine Kyoto Prefectural University Of Medicine
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Kohno Shigeru
佐世保市立総合病院 内科
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NAKAMURA Shigeo
Department of Clinical Pathology, Aichi Cancer Center Hospital
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Doi Yuko
Nagasaki Univ. Graduate School Of Biomedical Sci. Nagasaki Jpn
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TSURUTA Kazuto
the Department of Laboratory Midicine
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新田 紀子
神戸大学工学研究科機械工学専攻
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Totsune Kazuhito
東北大学 臨床薬学
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Tokunaga Katsushi
Department Of Clinical Pharmacology And Therapeutics Tohoku University Graduate School Of Pharmaceut
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Shibata Yoshisada
Department of Radiation Epidemiology, Nagasaki University Graduate School of Biomedical Sciences
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MORI Hirotaro
Research Center for Ultrahigh Voltage Electron Microscopy, Osaka University
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KONDO Hisayoshi
Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences
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NISHIDA Koichi
Department of Internal Medicine, Aiseikai Yamashina Hospital
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OHKAWARA Yasuo
Department of Internal Medicine, Aiseikai Yamashina Hospital
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Kawakami S
Department Of Laboratory Medicine Nagasaki University Graduate School Of Biomedical Sciences
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KODERA Yoshihisa
Department of Hematology, Japanese Red Cross Nagoya First Hospital
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TERAUCHI Takashi
Screening Technology and Development Division, Research Center for Cancer Prevention and Screening,
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Yamada Yasuaki
Department Of Laboratory Medicine Nagasaki University Graduate School Of Biomedical Sciences
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OGAWA Hiroyasu
Department of Molecular Medicine, Osaka University Graduate School of Medicine
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Sekiguchi Akiko
Department of Cardiology, Cardiovascular Institution
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SUZUKI Ritsuro
Department of HSCT Data Management, Nagoya University Hospital
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MATSUMOTO Kenji
Department of Allergy and Immunology, National Research Institute for Child Health and Development,
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CHOU Takaaki
Department of Internal Medicine, Niigata Cancer Center Hospital
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OHNISHI Kazunori
Department of Internal Medicine, Hamamatsu University School of Medicine
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HOTTA Tomomitsu
National Hospital Organization, Nagoya Medical Center
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ENDO Keigo
Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicin
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KOJIMA Masaru
Department of Anatomic and Diagnostic Pathology, Dokkyo University School of Medicine
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Kishimoto Yuji
Kansai Medical University Takii Hospital
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FUJIMOTO Yoshiko
Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Onishi Yasushi
Department Of Biostatistics School Of Public Health University Of Tokyo
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MATSUO Keitaro
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
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Kojima M
Department Of Anatomic And Diagnostic Pathology Dokkyo University School Of Medicine
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Kami Masahiro
Division Of Exploratory Research Institute Of Medical Science University Of Tokyo
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Kami Masahiro
Jr東京総合病院 血液内科
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TSUCHIYA Takeshi
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki Univer
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KOMODA Minori
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki Univer
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HORIO Kensuke
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki Univer
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MORIWAKI Yuji
Nagasaki CML Study Group
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TOMINAGA Shinya
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki Univer
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ITONAGA Hidehiro
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki Univer
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KOIDA Satoshi
Nagasaki CML Study Group
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ATSUTA Yoshiko
Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University
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OHYASHIKI Kazuma
First Department of Internal Medicine (Division of Hematology), Tokyo Medical University
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NAGAFUJI Koji
Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science
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TESHIMA Takanori
Center for Cellular and Molecular Medicine, Kyushu University Hospital
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MORI Shin-ichiro
Hematopoietic Stem Cell Transplantation Division, National Cancer Center Hospital
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HIDAKA Michihiro
Department of Internal Medicine, Kumamoto Medical Center, National Hospital Organization
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YOSHIBA Fumiaki
Department of Hematology and Oncology, Tokai University School of Medicine
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ICHINOHE Tatsuo
Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University
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TAKATSUKA Yoshifusa
Department of Hematology, Imamura Bun-in Hospital
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KUBO Kohmei
Department of Hematology, Aomori Prefectural Central Hospital
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YOSHIDA Takashi
Hematology Department, Toyama Prefectural Hospital
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HARADA Mine
Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science
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IIDA Shinsuke
Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sci
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Osaki Koichi
九州厚生年金病院
著作論文
- Allogeneic stem cell transplantation versus chemotherapy as post-remission therapy for intermediate or poor risk adult acute myeloid leukemia : results of the JALSG AML97 study
- Randomized trial of response-oriented individualized versus fixed-schedule induction chemotherapy with idarubicin and cytarabine in adult acute myeloid leukemia : the JALSG AML95 study
- Comparative analysis of remission induction therapy for high-risk MDS and AML progressed from MDS in the MDS200 study of Japan Adult Leukemia Study Group
- 点欠陥の自己組織化的挙動を利用した微細構造形成法
- Long-term efficacy of imatinib in a practical setting is correlated with imatinib trough concentration that is influenced by body size : a report by the Nagasaki CML Study Group
- Peripheral blood stem cell versus bone marrow transplantation from HLA-identical sibling donors in patients with leukemia : a propensity score-based comparison from the Japan Society for Hematopoietic Stem Cell Transplantation registry
- Lenalidomide plus dexamethasone treatment in Japanese patients with relapsed/refractory multiple myeloma
- Phase 1/2 clinical study of dasatinib in Japanese patients with chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia
- Japanese phase II study of ^Y-ibritumomab tiuxetan in patients with relapsed or refractory indolent B-cell lymphoma
- Geographical Study on the Frequency of Epilation among Atomic Bomb Survivors in Nagasaki
- Correlation between Acute Radiation Injuries and Hematological Parameters in Atomic Bomb Survivors
- Mental health conditions among atomic bomb survivors in Nagasaki
- Rapid isolation of viral integration site reveals frequent integration of HTLV-1 into expressed loci
- Monosomies 7p and 12p and FLT3 internal tandem duplication : possible markers for diagnosis of T/myeloid biphenotypic acute leukemia and its clonal evolution
- Multiple extra-articular synovial cysts complicated with rheumatoid arthritis
- Systemic sclerosis and pseudomesotheliomatous adenocarcinoma of the lung
- Imatinib Provides Durable Molecular and Cytogenetic Responses in a Practical Setting for Both Newly Diagnosed and Previously Treated Chronic Myelogenous Leukemia : A Study in Nagasaki Prefecture, Japan
- Phase II and pharmacokinetic study of thalidomide in Japanese patients with relapsed/refractory multiple myeloma
- Japanese epidemiological survey with consensus statement on Japanese guidelines for treatment of iron overload in bone marrow failure syndromes
- Aplastic Anemia
- 3 Geographic Effects on Cancer Mortality in Nagasaki A-Bomb Survivors(Atomic bomb effects, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- Multicenter Prospective Study of Interferon α versus Allogeneic Stem Cell Transplantation for Patients with New Diagnoses of Chronic Myelogenous Leukemia
- Human Herpesvirus 6 Meningoencephalitis in Allogeneic Hematopoietic Stem Cell Transplant Recipients
- Asymptomatic Patients with Acute Leukemias and Malignant Lymphomas Found in Ningen Dock
- Tocilizumab is effective for pulmonary hypertension associated with multicentric Castleman's disease
- Emergence of chronic myelogenous leukemia during treatment for essential thrombocythemia
- Cyclin-dependent kinase inhibitor SU9516 enhances sensitivity to methotrexate in human T-cell leukemia Jurkat cells
- Serum HO-1 is useful to make differential diagnosis of secondary hemophagocytic syndrome from other similar hematological conditions
- Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1
- Cerebral venous sinus thrombosis after allogeneic stem cell transplantation
- Clinical Significance of Fragmented Red Cells after Allogeneic Bone Marrow Transplantation
- Durable Remission by Sobuzoxane in an HIV-Seronegative Patient with Human Herpesvirus 8-Negative Primary Effusion Lymphoma
- A case of systemic lupus erythematosus complicated with pneumatosis cystoides intestinalis
- Use of musculoskeletal ultrasound in Japan : a survey of practicing rheumatologists
- Void Formation and Structure Change Induced by Heavy Ion Irradiation in GaSb and InSb
- Phase II study of oral fludarabine in combination with rituximab for relapsed indolent B-cell non-Hodgkin lymphoma
- Therapeutic angiogenesis in patients with systemic sclerosis by autologous transplantation of bone-marrow-derived cells
- Phase I study of the oral mammalian target of rapamycin inhibitor everolimus (RAD001) in Japanese patients with relapsed or refractory non-Hodgkin lymphoma
- Bortezomib for post-allogeneic hematopoietic stem transplantation relapse and GVHD in multiple myeloma : a single institute experience
- Bortezomib plus dexamethasone for relapsed or treatment refractory multiple myeloma : the collaborative study at six institutes in Kyoto and Osaka
- Phase I and pharmacokinetic study of bendamustine hydrochloride in relapsed or refractory indolent B-cell non-Hodgkin lymphoma and mantle cell lymphoma
- Formation of Defect Structure on Ge Surface by Ion Irradiation at Controlled Substrate Temperature
- Pure red cell aplasia caused by parvovirus B19 in two patients without chronic hemolysis
- Relevance of monitoring metabolic reduction in patients with relapsed or refractory follicular and mantle cell lymphoma receiving bendamustine : a multicenter study
- Analysis of bacteremia/fungemia and pneumonia accompanying acute myelogenous leukemia from 1987 to 2001 in the Japan Adult Leukemia Study Group
- Lack of non-hematological cross intolerance of dasatinib to imatinib in imatinib-intolerant patients with Philadelphia chromosome positive chronic myeloid leukemia or acute lymphatic leukemia : a retrospective safety analysis
- Expression of myeloperoxidase and gene mutations in AML patients with normal karyotype: double CEBPA mutations are associated with high percentage of MPO positivity in leukemic blasts.
- Successful treatment of a chronic-phase T-315I-mutated chronic myelogenous leukemia patient with a combination of imatinib and interferon-alfa
- Feasibility and pharmacokinetic study of bendamustine hydrochloride in combination with rituximab in relapsed or refractory aggressive B cell non-Hodgkin's lymphoma
- Phase I and II study of azacitidine in Japanese patients with myelodysplastic syndromes
- Intravascular B-cell lymphoma with hypercalcemia as the initial presentation
- Monosomy 13 in metaphase spreads is a predictor of poor long-term outcome after bortezomib plus dexamethasone treatment for relapsed/refractory multiple myeloma