Clinical Significance of Serum Soluble HLA Class I Antigens in Systemic Lupus Erythematosus
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概要
- 論文の詳細を見る
Serum soluble HLA (SHLA) class I antigens in patients with systemic lupus erythematosus (SLE) were examined by enzyme-linked immunosorbent assay. The primary antibody used was W6/32, anti-HLA class I mouse monoclonal antibody, and the secondary antibody was peroxidase-conjugated anti-mouse IgG antibody. The reactivity of SHLA class I antigens, the number of peripheral lymphocytes, and the clinical state of SLE were compared. The results were as follows; 1) Sixteen of 55 samples from SLE patients were SHLA class I antigen-positive (29%). 2) The reactivity of SHLA class I antigens was closely related to disease activity. 3) The number of lymphocytes and the reactivity of SHLA class I antigens were negatively correlated. 4) Nine of 23 samples from the active SLE patients were SHLA class I antigen-negative. Of these, 7 were from patients with a nephrotic syndrome due to lupus nephritis. It is concluded that SHLA class I antigens can be an useful marker for monitoring the clinical state of SLE.
- 東海大学の論文
著者
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SHIMURA TATSUO
Department of General Surgical Science (Surgery I), Gunma University Graduate School of Medicine
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Shimura Tatsuo
Department Of Surgery Gumma University School Of Medicine
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Shimura Tatsuo
東海大学 移植免疫
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Shimura Tatsuo
Department Of General Surgical Science (surgery I) Gunma University Graduate School Of Medicine
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Hagihara Masao
Department Of Hematology And Oncology Tokai University School Of Medicine
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TSUJI Kimiyoshi
Department of Transplantation Immunology, Tokai University School of Medicine
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TSUJI Shuichi
Department of Molecular Glycobiology, Frontier Research Program, RIKEN
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Tsuji S
Ochanomizu Univ. Tokyo Jpn
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Tsuji K
Department Of Transplantation Immunology Tokai University School Of Medicine
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Tsuji Kimiyoshi
Department Of Transplantation Ii School Of Medicine Tokai University
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YAMAMURA Masaichi
Department of Molecular Life Science, Tokai University School of Medicine
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YAMAMOTO Kozue
Transplantation Immunology Center, Tokai University Hospital
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SUJIRACHATO Kanchana
Department of Transplantation Immunology, Tokai University School of Medicine
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Yamamoto Kenji
Department Of Psychiatry Tokai University School Of Medicine
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Yamazaki K
Department Of Psychiatry Course Of Specialized Clinical Science Tokai University School Of Medicine
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Yamamoto Kenji
Department Of Psychiatry Kitasato University School Of Medicine
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Yamamura Masaichi
Department Of Biochemistry School Of Medicine Tokai University
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Yamamura Masaichi
Department Of Biochemistry Tokai University School Of Medicine
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Sujirachato K
Mahidol Univ.
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Tsuji Shuichi
Department Of Molecular Glycobiology Frontier Research Program Riken
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TSUJI Shuichi
Department of Internal Medicine, Kawasaki Municipal Hospital
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TSUJI KIMIYOSHI
Department of Radiology, School of Medicine, Keio University
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