Alpha-1-Antichymotrypsin (ACT) as an Immune Regulatory Agent

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概要

• 論文の詳細を見る

• This study was carried out to elucidate the interaction of alpha-1-antichymotrypsin (ACT) with the immune reaction induced by interleukin-2 (IL-2). ACT, isolated from human sera and determined to be a single glycoprotein, was added to human peripheral T-cell cultured with IL-2. It was found that ACT effectively suppressed T-cell activation induced by IL-2, but the suppressive effect of ACT was inversely proportional to the concentration of IL-2. A similar effect was found when T-cells were stimulated with PHA. ACT had a suppressive effect when suboptimal concentrations of PHA were used, however this suppressive effect could not be found at the optimal PHA concentration. These findings suggest that ACT may be a regulatory agent in immune reactivity where low concentrations of IL-2 are present. Even under normal conditions, an individual is surrounded and invaded by numerous foreign elements and it may be that small amounts of IL-2 are constantly produced, which would indefinitely trigger chained immune reactions if there were no regulatory agent like ACT.

• 1988-03-17

著者

• Nakamura Kenji

  Department of Surgery, Tokai University School of Medicine

• KATSUNUMA Tsunehiko

  Department of Biochemistry and Microbiology, School of Medicine Tokai University

• YAMAMURA Masaichi

  Department of Molecular Life Science, Tokai University School of Medicine

• NAKAMURA Kazue

  Department of Biochemistry, School of Medicine, Tokai University

• Nakamura K

  Department Of Surgery Tokai University School Of Medicine

• KURAHASHI Kazuo

  Department of Biochemistry, School of Medicine, Tokai University

• KATO Kazumasa

  Department of Biochemistry, School of Medicine, Tokai University

• Kurahashi Kazuo

  Department Of Biochemistry School Of Medicine Tokai University

• Katsunuma T

  Tokai Univ. Kanagawa Jpn

• Kato Kazumasa

  Department Of Biochemistry School Of Medicine Tokai University

• Yamamura M

  Tokai Univ. School Of Medicine

• Yamamura Masaichi

  Department Of Biochemistry School Of Medicine Tokai University

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