The Role of the Brain in Immune Response in Rats

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概要

• 論文の詳細を見る

• To prove our hypothesis that there is a higher level center of the immune system in the brain itself than in the thymus and that the brain, including the hypothalamus and cerebrum, may play a role in controlling immune regulation in mammals, immune responses following brain transection and/or cerebroectomy in rats were investigated. We observed: 1) markedly decreased thymus and spleen weights and significant involution in thymus and spleen tissues microscopically but no change in the adrenals; 2) slightly inhibited formation of anti-SRBC antibody and delayed immunological transmission; 3) no significant change in mitogen induced transformation in axillary lymph nodes and spleen cells; and 4) no change in hormone levels, thyroxine, growth hormone and cortisone 3, 5 and 7 days after cerebroectomy inhibited the immunological competent tissue due to bankruptcy of direct or indirect immunological transmission from the brain.

• 東海大学の論文

著者

• Saito Yutaka

  Department Of Pharmaceutical Sciences Graduate School Of Medicine And Dentistry And Pharmaceutical S

• KOMORI Kiyotaka

  Department of Transplantation, Tokai University

• Tsuji Kimiyoshi

  Department Of Transplantation Tokai University

• Tsuji Kimiyoshi

  Department Of Transplantation Ii School Of Medicine Tokai University

• Inouye Hiroo

  Department Of Transplantation Tokai University

• Ozawa Atsushi

  Department Of Cardiology St. Marianna University Yokohama City Seibu Hospital

• Ito Motoaki

  Department Of Transplantation School Of Medicine Tokai University

• Ito Motoaki

  Department Of Bioscience School Of Science And Technology Kwnasei Gakuin University

• SHIRAISHI Takemasa

  Department of Physiology, School of Medicine, Tokai University

• Komori Kiyotaka

  Department Of Transplantation Tokai University

• UNOKUCHI Toshiro

  Department of Transplantation, School of Medicine, Tokai University

• KOMORI Kiyokazu

  Department of Transplantation, School of Medicine, Tokai University

• Shiraishi Takemasa

  Department Of Physiology School Of Medicine Tokai University

• Unokuchi Toshiro

  Department Of Transplantation School Of Medicine Tokai University

• Saito Yutaka

  Department Of Endoscopy National Cancer Center Hospital

• Saito Yutaka

  Department Of Neurosurgery Tokyo Medical College

• Ozawa Atsushi

  Department Of Bacteriology 2nd National Tokyo Hospital

• TSUJI KIMIYOSHI

  Department of Radiology, School of Medicine, Keio University

• Saito Yutaka

  Department of Chemistry, Nagaoka University of Technology

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