Effect of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) on Allogeneic Bone Marrow Transplantation in Mice
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概要
- 論文の詳細を見る
The effects of recombinant human granulocyte colony stimulating factor (rhG-CSF) on the survival rate and hemopoiesis after allogeneic bone marrow transplantation (BMT) was examined. Specific pathogen-free (SPF) C3H mice, kept in a flexible isolator for germ-free animals, received 10Gy of total body irradiation (TBI), and an allogeneic BMT 24 hours later. The 14 day survival rate was 33%. When the mice were received rhG-CSF (30 μg/kg/day subcutaneously) daily for 2 weeks following BMT, the 14 day survival rate rose to 79%. The effect of rhG-CSF treatment on hemopoiesis in BMT mice resulted in higher neutrophil counts in the peripheral blood by day 14 post-BMT. Administration of rhG-CSF after allogeneic BMT benefited survival rate and neutrophil recovery without any apparent complications.
- 東海大学の論文
- 1990-03-08
著者
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Ozawa Atsushi
Department of Cardiology, Yokohama City Seibu Hospital, St. Marianna University
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MORI Tomoyuki
Department of Radiology, School of Medicine, Tokai University
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Ohnishi Nobuhiko
Department of Cardiology, Mitoyo General Hospital
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Mori Tomoyuki
Department Of Radiation Oncology School Of Medicine Tokai University
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Mori Tomoyuki
Department Of Biomolecular Sciences Saga Medical School
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Ozawa Atsushi
Department Of Cardiology St. Marianna University Yokohama City Seibu Hospital
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FUKUHARA Noboru
Department of Radiation Oncology, School of Medicine, Tokai University
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Fukuhara Noboru
Department Of Radiation Oncology School Of Medicine Tokai University
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Ohnishi Nobuhiko
Department Of Cardiology Mitoyo General Hospital
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Ozawa Atsushi
Department Of Bacteriology 2nd National Tokyo Hospital
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