Polarographic Measurement of Misonidazole in Mouse Mammary Tumors
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概要
- 論文の詳細を見る
The sensitizing effect of misonidazole, a hypoxic cell radiosensitizer, is presumed to be due to its strong electron affinity. The concentration of misonidazole in mouse mammary tumors was measured polarographically in vivo. When 1 mg of misonidazole per gram body weight was administered intraperitoneally to C3H/He mice, 0.5-0.75 mM of misonidazole was observed in the tumors 25-60 min later. The distribution of misonidazole in the tumors varied, but the mean concentrations were not significantly different except in the necrotic area and the central-superficial region, where the concentration of misonidazole tended to be lower than in the other regions. No differences in the concentration of misonidazole were observed in tumors with diameters ranging from 4 to 11 mm. The polarographic measurement of misonidazole in vivo is technically simple and can be applied to the study of hypoxic cells in tumor tissue.
- 東海大学の論文
著者
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母里 知之
東海大学 放射線
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母里 知之
Department Of Radiation Oncology School Of Medicine Tokai University
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MURAYAMA Chieko
Department of Radiation Oncology, School of Medicine, Tokai University
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大泉 幸雄
東海大学医学部放射線科学教室
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MAEZAWA HIROSHI
Department of Radiology, School of Medicine, Tokai University
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MORI Tomoyuki
Department of Radiology, School of Medicine, Tokai University
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前沢 博
Sch. Health Science Univ. Tokushima
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Maezawa Hiroshi
Department Of Molecular Biology School Of Medicine Tokai University
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Murayama Chieko
Department Of Radiation Oncology School Of Medicine Tokai University
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OHIZUMI Yukio
Department of Radiation Oncology, Tokai University School of Medicine
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Oizumi Yukio
Department Of Radiation Oncology Tokai University School Of Medicine
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Ohizumi Y
Department Of Radiation Oncology Tokai University School Of Medicine
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Mori T
Tokai University Hospital
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Mori Tomoyuki
Department Of Biomolecular Sciences Saga Medical School
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Ohizumi Yukio
Department Of Radiation Oncology Tokai University School Of Medicine
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Ohizumi Yukio
Department Of Radiation Oncology School Of Medicine Tokai University
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Maezawa H
Department Of Radiation Oncology School Of Medicine Tokai University
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Maezawa H
Dept. Radiat. Oncol. Tokai Univ. Sch. Med.
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