The Effect of Hypoxic Radiosensitizer after Mild Hyperthermia in C3H Mammary Carcinoma
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概要
- 論文の詳細を見る
The radiosensitizing effect of misonidazole after hyperthermia was investigated in C3H mammary carcinoma. The tumors transplanted into the flanks of the mice were heated in a 42.3℃ water bath for 30 min. When misonidazole was administrated before heating, the subsequent radiation effect was prominently enhanced, whereas postheating administration of misonidazole did not enhance the radiation effect significantly. The effect of varing the time between heating and radiation with or without misonidazole was as follows. Without misonidazole, the radiation effect was decreased at 6 hours after heating but increased at 12 hours, then it returned to the initial level at 24 hours and remained until 96 hours after heating. With misonidazole administered 30 min before irradiation, the radiosensitizing effect was observed at 24, 48 and 96 hours after heating. However, the total effects of this procedure were almost the same as the results in the combination without heating. Changes in the hypoxic fraction after hyperthermia are also discussed.
- 東海大学の論文
著者
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母里 知之
東海大学 放射線
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MURAYAMA Chieko
Department of Radiation Oncology, School of Medicine, Tokai University
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大泉 幸雄
東海大学医学部放射線科学教室
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MAEZAWA HIROSHI
Department of Radiology, School of Medicine, Tokai University
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MORI Tomoyuki
Department of Radiology, School of Medicine, Tokai University
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前沢 博
Sch. Health Science Univ. Tokushima
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Maezawa Hiroshi
Department Of Molecular Biology School Of Medicine Tokai University
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Murayama Chieko
Department Of Radiation Oncology School Of Medicine Tokai University
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OHIZUMI Yukio
Department of Radiation Oncology, Tokai University School of Medicine
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Oizumi Yukio
Department Of Radiation Oncology Tokai University School Of Medicine
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Mori Tomoyuki
Department Of Radiation Oncology Tokai University School Of Medicine
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Mori T
Tokai University Hospital
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Mori Tomoyuki
Department Of Biomolecular Sciences Saga Medical School
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母里 知之
Department Of Radiation Oncology Tokai University School Of Medicine
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Ohizumi Yukio
Department Of Radiation Oncology Tokai University School Of Medicine
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Maezawa Hiroshi
東海大学 放射線
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Ohizumi Yukio
Department Of Radiation Oncology School Of Medicine Tokai University
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Maezawa H
Department Of Radiation Oncology School Of Medicine Tokai University
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