Hyperthermia Combined with Re-Irradiation for Neck Node Metastasis from Head and Neck Cancer

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The effects of hyperthermia combined with re-irradiation were compared with those of reirradiation alone using retrospectively matched-pair analysis. Between 1984 and 1997, 12 patients were treated with hyperthermia combined with re-irradiation for neck node metastasis from squamous cell carcinoma of the head and neck. During the same period, 12 patients treated with re-irradiation alone were selected retrospectively using the same anatomical diagnosis, nodal site, and nodal size. Recurrent nodes were heated by a 2450MHz microwave or 13MHz radio frequency 4 times on average for 30 to 50 min immediately before radiotherapy. The maximum temperatures were >41℃ in 83% and >42℃ in 58% of patients. Results: The median survival and median recurrence periods were 12 months and 6 months, respectively in both groups. The response rate was 83% in both groups. Nodal size and radiation dose, but not heating temperature, were prognostic factors. Five patients in the hyperthermia group experienced skin ulcers or burns as acute complications. Late complications were observed in one patient in the hyperthermia group and 3 patients in the reirradiation-alone group. Conclusion: Heating induced acute complications and had no significant effect on the tumors. Further advances in hyperthermic technique are required.
東海大学の論文