RADIOSENSITIZING HYPOXIC CELLS WITH NEW 3-NITRO-1,2,4-TRIAZOLE DERIVATIVES IN VITRO AND IN VIVO

概要

論文の詳細を見る
The new regioisomer derivatives <4a>___〜-f__〜 and <5a>___〜-f__〜 of 3-nitro-1,2,4-triazole (3-NTR) were synthesized for the development of new radiosensitizers of hypoxic cancer cells for radiotherapy. N(2)-Substituted 3-NTR derivatives <5a>___〜-f__〜 were stronger radiosensitizers of hypoxic cells in vitro (Chinese hamster V79 cells) than N(1)-substituted 3-NTR derivatives <4a>___〜-f__〜, but in vivo they were weaker (SCCVII carcinoma cells inoculated into C3H/He mouse).
社団法人日本薬学会の論文
1989-07-25