Early Skin Response to Fractionated Doses of Pions for Determining Therapeutic Gain Factors
スポンサーリンク
概要
- 論文の詳細を見る
This study concerns the biological effectiveness of fractionated doses of pions on early skin reactions near the implanted tumor, to evaluate the therapeutic gain factors of pions. The C3H mouse limbs bearing microscopical SCCVII tumors were irradiated with pions (9.6-38.4 Gy) or x-rays (14.4-50.4Gy) in 2-7 fractions. Nicotinamide (500mg/kg) and carbogen (a mixture of 95% O_2+5% CO_2), as hypoxic radiosensitizers, were administered prior to the x-rays, to confirm the presence of hypoxic cells in the skin. The mean skin scores and number of damaged nails assessed. The ratios of x-ray/pion doses needed for giving comparable skin reactions were 1.3-1.5. Nicotinamide and carbogen enhanced the skin reactions. When the ratios were compared with those of tumor cure, the pions showed no therapeutic gains. One of the possible causes was that the presence of hypoxic cells in the skin may have reduced the therapeutic gain.
- 東海大学の論文
著者
-
Lam Gabriel
Batho Biomedical Facility
-
OHIZUMI Yukio
Department of Radiation Oncology, Tokai University School of Medicine
-
Chaplin David
Department Of Medical Biophysics British Columbia Cancer Research Center
-
Ohizumi Y
Department Of Radiation Oncology Tokai University School Of Medicine
-
PICKLES Tom
Section of Developmental Radiotherapy, British Columbia Cancer Agency
-
Ohizumi Yukio
Department Of Radiation Oncology Tokai University School Of Medicine
-
Ohizumi Yukio
Department Of Radiation Oncology School Of Medicine Tokai University
関連論文
- Primary radiotherapy for tongue cancers with a tumor thickness exceeding 1 cm
- Prediction of Tumor Control by Tumor Regression at 40 Gy/4 Weeks of External Beam Irradiation for Oropharyngeal Carcinoma
- Hyperthermia Combined with Re-Irradiation for Neck Node Metastasis from Head and Neck Cancer
- Vaginal Applicators (ovoids) for Local Control and Alleviation of Rectal Complications of Cervical Cancers Treated by Brachytherapy
- Epinephrine or Peplomycin Combined with Hyperthermia in Irradiated Lewis Lung Carcinoma : Effects on Tumor Growth, Skin Reaction, and Lung Metastasis
- Local Control Rate of Split-course Irradiation Combined with Chemotherapy for Head and Neck Cancer
- Early Skin Response to Fractionated Doses of Pions for Determining Therapeutic Gain Factors
- Radiosensitizing Effect of Nicotinamide and Carbogen Combined in Fractionated Pions or X - Rays in SCCVII Tumors
- Biological Effectiveness of Fractionated Dose of Pions in Microscopic SCCVII Tumors: Comparison between Tumor Control Dose and Tumor Growth Time Assays
- Radiosensitizing Effects of Adriamycin on Hypoxic Cells
- Synergistic Effects of Hyperthermia and Intratumorous Injection of Anti-Cancer Drugs
- Relationship between Primary Tumor Volume and Lung Metastasis in Lewis Lung Carcinoma : (II) Tumor Bed Effect
- Relationship between Primary Tumor Volume and Lung Metastasis in Lewis Lung Carcinoma : (1) Assay for Time Course of Development of Metastasis
- The Effect of Hypoxic Radiosensitizer after Mild Hyperthermia in C3H Mammary Carcinoma
- Polarographic Measurement of Misonidazole in Mouse Mammary Tumors
- The Relative Effectiveness of the Modulated Proton Beam at TRIUMF