Serum N-3 Polyunsaturated Fatty Acid Levels Correlate With the Extent of Coronary Plaques and Calcifications in Patients With Acute Myocardial Infarction
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概要
- 論文の詳細を見る
Background The relationship between serum fatty acid levels and the extent of coronary plaques and calcification was examined in patients with acute myocardial infarction (AMI). Methods and Results The serum levels of the n-3 polyunsaturated fatty acids (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) and the n-6 polyunsaturated fatty acids (arachidonic acid (AA) and dihomo-gamma-linolenic acid (DGLA)) were determined using gas chromatography on admission of 95 consecutive patients with their first AMI and 17 controls. Using multidetector-row computed tomography, soft plaques and calcification lesions were scored according to the extent of coronary involvement. Serum logarithmic transformed (log) EPA and logDHA levels were inversely correlated with soft plaque scores (r=-0.546, p<0.0001 and r=-0.377, p<0.0001, respectively). Serum logAA and logDGLA levels were not significantly correlated with soft plaque scores. Serum logEPA and logDHA levels were significantly, but weakly, correlated with calcification scores. Multivariate analysis with clinical characteristics and risk factors selected serum n-3 polyunsaturated fatty acid levels as independent factors associated with the extent of coronary soft plaques. Conclusion The present study demonstrates a significant correlation between serum n-3 polyunsaturated fatty acid levels and the extent of coronary soft plaques and calcification in AMI patients.
- 社団法人日本循環器学会の論文
- 2008-10-20
著者
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Kusachi Shozo
Department of Medical Technology, Okayama University Medical School
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MIYOSHI Toru
Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, De
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HIROHATA Satoshi
Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, De
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Kusachi Shozo
Department Of Medical Technology Okayama University Graduate School Of Health Sciences
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Kusachi Shozo
Department Of Medical Technology Faculty Of Medical Sciences Okayama University Medical School
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Kusachi Shozo
The First Department Of Internal Medicine
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Ueeda Masayuki
Department Of Cardiology Mitoyo General Hospital
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Ueeda Masayuki
Division Of Cardiology Mitoyo General Hospital
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Katayama Yusuke
Division Of Cardiovascular Medicine Mitoyo General Hospital
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Hirohata Satoshi
Department Of Molecular Biology And Biochemistry Okayama University Graduate School Of Medicine Dent
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Doumei Takenori
Division of Cardiovascular Medicine, Mitoyo General Hospital
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Takaya Yoichi
Division of Cardiovascular Medicine, Mitoyo General Hospital
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Shinohata Ryoko
Department of Medical Technology, Okayama University Graduate School of Health Sciences
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Ohnishi Nobuhiko
Division of Cardiovascular Medicine, Mitoyo General Hospital
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Takaishi Atsushi
Division of Cardiovascular Medicine, Mitoyo General Hospital
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Miyoshi Toru
Department Of Molecular Biology And Biochemistry Okayama University Graduate School Of Medicine Dent
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Domei Takenori
Division Of Cardiovascular Medicine Mitoyo General Hospital
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Takaishi Atsushi
Department Of Cardiology Mitoyo General Hospital
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Takaishi Atsushi
Division Of Cardiology Mitoyo General Hospital
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Hirohata Satoshi
Department Of Molecular Biology And Biochemistry Okayama University Graduate School Of Medicine And
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Ohnishi Nobuhiko
Department Of Cardiology Mitoyo General Hospital
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Kusachi Shozo
Okayama University Medical School
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Saito Kouhei
Department Of Biological Science And Technology Science University Of Tokyo
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Onishi Nobuhiko
Division Of Cardiology Mitoyo General Hospital
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Kusachi Shozo
Dept Of Mol Biol And Biochem Okayama Univ Grad Sch Of Med And Dent:dept Of Nursing Niimi College
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Takaya Yoichi
Department Of Cardiology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
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Shinohata Ryoko
Department Of Medical Technology Okayama University Graduate School Of Health Sciences
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Hirohata Satoshi
Department Of Molecular Biology And Biochemistry Okayama University Graduate School Of Medicine And
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Miyoshi Toru
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sciences
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Hirohata Satoshi
Department of Medical Technology, Okayama University Graduate School of Health Sciences, Japan
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Kusachi Shozo
Department of Internal Medicine I, Okayama University Medical School
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