AUTO-ANTIBODY AGAINST ADENINE NUCLEOTIDE TRANSLOCATOR IN DILATED CARDIOMYOPATHY AND MYOCARDITIS : Incidence and Relation to Cardiac Function and Morphology
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概要
- 論文の詳細を見る
Using an enzyme-linked immunosorbent assay, we measured anti-adenine nucleotide translocator (ANT) antibody in control subjects and in patients with dilated cardiomyopathy (DCM), myocarditis, and other heart diseases. Analysis with sodium dodecyl sulfate-polyacrylamide gel electrophoresis, Western blotting, and immunoabsorption tests confirmed accurate purification of the ANT protein and correct measurememt of anti-ANT auto-antibody. Anti-ANT anti-body was detected in 6 of 37 cases (16%) of DCM and in 5 of 12 cases (42%) of myocarditis. This antibody was not positive in other heart diseases or in apparently healthy controls. There were no differences between anti-ANT autoanti-body-positive and -negative DCM or myocarditis patients in any of the cardiac parameters examined (left ventricular ejection fraction, LVEF; left ventricular end-diastolic dimension, LVDd; and cardiothoracic ratio, CTR). Moreover, in patients who were positive for anti-ANT auto-antibody, no positive correlations were found between the parameters and anti-ANT antibody titers in either DCM or myocarditis. Although these results indicate that the detection of anti-ANT antibody was achieved at a high specificity and could have certain diagnostic value in DCM and myocarditis, there was no statistically significant relationship between the cardiac parameters (LVEF, LVDd, and CTR) and anti-ANT antibody titers in either DCM or myocarditis. Some compensatory mechanism of ventricular function may mask the effects of the anti-ANT auto-antibody or alternatively, this auto-antibody may have mimic effects on the pathogenesis and/or progression of DCM and myocarditis.
- 社団法人日本循環器学会の論文
- 1993-11-20
著者
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TSUJI TAKAO
The First Depertment of Internal Medicine, Okayama University Medical School
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Kusachi Shozo
The First Department of Internal Medicine, Okayama University Medical School
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Takemoto Masao
The First Department Of Internal Medicine Okayama University Medical School
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Kusachi Shozo
The First Department Of Internal Medicine
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URABE NORIO
The First Department of Internal Medicine, Okayama University Medical School
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INOUE KIMIHITO
The First Department of Internal Medicine, Okayama University Medical School
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Tsuji Takao
The First Department Of Internal Medicine
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Urabe Norio
Dept Of Mol Biol And Biochem Okayama Univ Grad Sch Of Med And Dent:dept Of Med And Medical Sci Okaya
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Inoue Kimihito
The First Department Of Internal Medicine Okayama University Medical School
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