SCN5A Mutation Is Associated With Early and Frequent Recurrence of Ventricular Fibrillation in Patients With Brugada Syndrome
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概要
- 論文の詳細を見る
Background: Mutations in SCN5A are reportedly linked to Brugada syndrome (BS), but recent observations suggest that they are not necessarily associated with ventricular fibrillation (VF) in BS patients. Therefore, the clinical importance of SCN5A mutations in BS patients was examined in the present study. Methods and Results: The 108 BS patients were examined for SCN5A mutations and various parameters were compared between patients with and without mutations. An implantable cardioverter defibrillator (ICD) was implanted in 49 patients and a predictor of appropriate ICD shock was investigated. The existence of a SCN5A mutation was not associated with initial VF episodes (21.7% vs 20.0%, P=0.373). In the secondary prevention group, appropriate shock-free survival rate was significantly lower in patients with spontaneous type 1 ECG than in those without (41.1% vs 85.7% at 2 years, P=0.014). The appropriate shock-free survival rate was also significantly lower in patients with SCN5A mutations than in those without (28.6% vs 83.3% at 1 year, P=0.040). Appropriate shock was more frequent in patients with SCN5A mutations than in those without (6.6±6.2 vs 1.7±3.0, P=0.007). Conclusions: SCN5A mutations are associated with early and frequent VF recurrence, but not with initial VF episodes. This is the first report on the genotype-phenotype interaction and clinical significance of this mutation. (Circ J 2010; 74: 2572-2578)
- 社団法人 日本循環器学会の論文
- 2010-11-25
著者
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Nagata S
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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ITO Hiroshi
Department of Internal Medicine, Division of Cardiovascular Medicine, Akita University Faculty of Me
-
Tsuji T
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine And Dentistry
-
Maruyoshi Hidetomo
Department Of Bioscience National Cardiovascular Center Research Institute
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Maruyama Masahiko
Cardiovascular Medicine The Sakakibara Heart Institute Of Okayama
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Kusano Kengo
Dep. Of Cardiovascular Medicine Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Ok
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Ohe Tohru
Department of Cardiovascular Medicine, Okayama University Graduate School of Medical and Dentistry
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Tsuji T
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
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Morita Hiroshi
Department of Cardiology, Shingu Munichipal Hospital
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Ogawa Masahiro
Department of Cardiology, Fukuoka University School of Medicine
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Nagase Satoshi
Dep. Of Cardiovascular Medicine Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Ok
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Nakatani Satoshi
国立循環器病センター
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Ohe T
Dep. Of Cardiovascular Medicine The Sakakibara Heart Inst. Of Okayama
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Ohe Tohru
Japanese Lqts Multicenter Registry By The Minister Of Health Lobour And Welfare National Cardiovascu
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Ohe Tohru
群馬県立心臓血管センター 循環器内科
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Ohe Tohru
国立循環器病センター
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Ohe Tohru
J-rhythm Study
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Nishii Nobuhiro
Department of Cardiovascular Medicine Okayama University
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Nagase Satoshi
Department of Cardiovascular Medicine Okayama University
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Nakamura Kazufumi
Department of Cardiovascular Medicine Okayama University
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Kusano Kengo
Department of Cardiovascular Medicine Okayama University
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Tada Takeshi
Department of Cardiovascular medicine, Okayama University Graduate School of Medicine
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Murakami Masato
Department of Cardiovascular Medicine, Okayama University graduate school of Medicine
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Miura Daiji
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine
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Nakagawa Koji
Department of Cardiology, Okayama University School of Medicine
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Banba Kimikazu
Department of Cardiovascular Medicine, Okayama University
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Nagase Satoshi
群馬県立心臓血管センター 循環器内科
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Nishii Nobuhiro
Department Of Cardiology Okayama University Graduate School Of Medicine
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Matsubara H
Dep. Of Cardiovascular Medicine Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Ok
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Morita Hiroshi
岡山大学 医歯薬学総合研究科循環器内科
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Hiramatsu Shigeki
Department Of Cardiovascular Medicine Okayama University Graduated School Of Medicine Density And Ph
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Kohno Kunihisa
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine
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Kohno Kunihisa
Department Of Cardiology National Hospital Organization Iwakuni Clinic Center
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Kohno Kunihisa
岡山大学 第2生理
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Kohno Kunihisa
Department Of Physiology Ii Okayama University Medical School
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Nakamura Seishi
Division Of Cardiology Takarazuka Hospital
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Kuroki Kenji
筑波大学 人間総合科学研究科循環器内科
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Kumagai K
The Cardiovascular Center Yokosuka Kyousai Hospital
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Saku Keijiro
Department Of Cardiology Fukuoka University Faculty Of Medicine
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Saku Keijiro
福岡大学 医学研究科臨床研究科学
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Saku Keijiro
福岡大学 医学部心臓血管内科学
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Takai M
Department Of Physiology Ii Nara Medical University
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Mori H
国立病院機構岡山医療センター 循環器科
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Mori H
Department Of Bioscience Department Of Cardiovascular Surgery
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Koyama Keiko
群馬大学 医学系研究科臓器病態内科学
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Nakatani Satoshi
Cardiology Division Of Medicine National Cardiovascular Center
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Ohe Tohru
岡山大学 循環器内科
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Ohno Tetsuo
東京慈恵会医科大学 生理学第1
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Kusano Kengo
岡山大学 医歯薬学総合研究科循環器内科
-
Kusano Kengo
Japanese Brugada Multicenter Registry By The Minister Of Health Labour And Welfare National Cardiova
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Fukushima (kusano)
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine
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Nakamura K
Division Of Cardiology Gunma Prefectural Cardiovascular Center
-
Tanaka Masamichi
Department of Cardiology, Okayama University Graduate School of Medicine
-
Fukushima Kusano
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
-
Kengo Fukushima
Departments Of Cardiovascular Medicine
-
Nagase Satoshi
Department Of Cardiovascular Medicine Okayama University Graduated School Of Medicine Density And Ph
-
Matsunaga Akira
Department Of Cardiology Fukuoka University
-
Kitamura Satoko
国立循環器病センター 心臓血管内科
-
Kajinami Kouji
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
-
Matsubara Hiromi
Departments of Cardiovascular Medicine
-
Nakamura Koki
Division Of Cardiology Gunma Prefectural Cardiovascular Center
-
Ohe Tohru
岡山医療センター 循環器科
-
Ohe Tohru
Department Of Cardiovascular Medicine Okayama University
-
Kuroki Kenji
Cardiology Department Of Internal Medicine University Of Tsukuba Graduate School Of Comprehensive Hu
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Saku Keijiro
Fukuoka University
-
Tada Takeshi
Department Of Biological And Environmental Chemistry Faculty Of Agriculture Tottori University
-
Kimura Hideo
Department Of Cardiology National Hospital Organization Okayama Medical Center
-
Horiba Mitsuru
名古屋大学環境医学研究所 循環器学
-
Kawamura Hiroshi
Cardiovascular Center Sakakibara Hospital
-
Minami Hitosi
Department of Cardiovascular Physiology
-
Kusano Hitoshi
Fukushima-Naika Clinic
-
Urakawa Shigemi
Department Of Cardiovascular Medicine Okayama University
-
Murakami Masahiro
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine And Dentistry
-
Nakamura Kazufumi
Department Of Cardiology Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical
-
Mori Hidezo
The Native
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Matsunaga Akira
Fukuoka University, School of Medicine
-
Horie Minoru
Department Of Cardiopulmonary Medicine Shiga University Of Medical Science
-
Matsumori Akira
Department Of Cardiovascular Medicine Kyoto University Graduate Shool Of Medicine
-
Murakami Masato
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine
-
Murakami Takashi
Department Of Cardiology Okayama University School Of Medicine
-
Kaseno Kenichi
Gunma Prefectural Cardiovascular Center
-
Tsuji Takao
The First Depertment Of Internal Medicine Okayama University Medical School
-
Ogawa Masahiro
Department Of Cardiology Fukuoka University School Of Medicine
-
Ito Hiroshi
Department Of Cardiovascular And Respiratory Medicine Akita University Graduate School Of Medicine
-
Fukushima Kusano
Department Of Cardiovascular Medicine Okayama University Medical School
-
Katoh Kenichi
Yokohama Rousai Hospital Department Of Cardiology
-
Murakami Masato
Department Of Cardiology Okayama University Graduate School Of Medicine
-
Ohe Tohru
岡山大学 医歯薬学総合研究科循環器内科
-
Ohe Tohru
Department Of Cardiovascular Surgery And Cardiology
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Tsuji Takao
The First Department Of Internal Medicine
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Koura Kenji
Cardiovascular Center Yokosuka Kyosai Hospital
-
Nakamura Kazufumi
Division Of Cardiology Gunma Prefectural Cardiovascular Center
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Nagase Satoshi
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
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Mitani Hironobu
Research Division Tsukuba Research Institute Novartis Pharma K. K.
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Banba Kimikazu
Department Of Cardiovascular Medicine Okayama University
-
Banba Kimikazu
Department Of Cardiology Kochi Health Sciences Center
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Miyaji Kohei
Department Of Cardiology Okayama University Graduate School Of Medicine
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Kusano Kengo
Department Of Cardiovascularmedicine Okayama University
-
Saku Keijiro
Department Of Cardiology Fukuoka University School Of Medicine Fukuoka University
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Ohe Toru
Department Of Cardiology Okayama University
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Nagai Masahiro
Fukuyama Cardiovascular Hospital
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Nakatani Satoshi
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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OGAWA Masahiro
Fukuoka University School of Medicine
-
KUMAGAI Naoko
Fukuoka University School of Medicine
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URAKAWA Shigemi
National Hospital Organization Okayama Medical Center
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MIYAJI Kohei
National Hospital Organization Okayama Medical Center
-
SATOH Katsumasa
Fukuyama Cardiovascular Hospital
-
Hiramatsu Shigeki
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
-
Ohe Tohru
Cardiovascular Medicine Okayama University Medical School
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Mitani Hidenobu
Cardiovascular Surgery Okayama University Graduate School Of Medicine And Dentistry
-
Moritan Toshiyuki
Departments Of Physiology Ii Okayama University Medical School
-
Mikohchi Hiroshi
Division Of Cardiology National Hospital Organization Okayama Medical Center
-
Koyama Keiko
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
-
Ohe Tohru
Division Of Cardiology Department Of Medicine National Cardiovascular Center
-
Nakagawa Koji
Department Of Cardiology Okayama University
-
Miura Daiji
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
-
Nakatani Satoshi
Division Of Functional Diagnostics Department Of Health Sciences Osaka University Graduate School Of
-
Kumagai Naoko
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
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Taguchi Takehito
Department Of Radiological Technology Faculty Of Health Sciences Okayama University School Of Medici
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Nakamura Kazufumi
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
-
Murakami Masaaki
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
-
Nakahawa Koji
Department Of Cardiology Okayama University
-
Matsunaga Akira
Fukuoka University School Of Medicine
-
Murakami Masato
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine And Dentistry
-
Nagase Satoshi
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
-
Murakami Masaaki
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
-
Nakanishi Norifumi
Departments Of Internal Medicine National Cardiovascular Center
-
Morita Hiroshi
Department Of Applied Physics Graduate School Of Engineering The University Of Tokyo:crest Japan Sci
-
Nakarnura Seishi
2nd Dept. Of Int. Med. Kansai Medical Univ.
-
Fukushima Kusano
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
-
Morita Hiroshi
Department Of Applied Chemistry School Of Engineering Kanagawa University
-
Ohe Tohru
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
-
Mori Hidezo
Department Of Bioscience National Cardiovascular Center Research Institute
-
Ito Hiroshi
Department Neurosurgery Tokyo Medical College
-
Miyasaka Takehiro
Department Of Health Care Science Hijmeji Dokkyo University
-
Nagase Satoshi
Division Of Health Sciences Osaka University Graduate School Of Medicine
-
Nakamura Satoko
Department Of Internal Medicine National Cardiovascular Center
-
Nagase Satoshi
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
-
Saku Keijiro
Department Of Internal Medicine Fukuoka University School Of Medicine
-
Hirota Masanori
Department Of Cardiac Physiology National Cardiovascular Center Research Institute
-
Fukushima Kusano
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And P
-
Ohno Tetsuo
Department Of Cardiology Okayama University
-
Ohe Tohru
Department Of Cardiology Okayama University
-
Ito Hiroshi
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sciences
-
Fukushima Kusano
Department Of Cardiovascular Medicine Okayama University
-
Taguchi T
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sciences
-
Tada Takeshi
Department Of Cardiovascular Medicine Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Science
-
Satoh Nagato
Department Of Cardiovascular Medicine National Cardivascular Center
-
Numata Satoshi
National Cardiovascular Center Department Of Cardiovascular Surgery
-
Kuga Keisuke
Department Of Cardiovascular Medicine Okayama University
-
Takaki Miyako
Department Of Physiology Ii Nara Medical University School Of Medicine
-
NAKAMURA Kazufumi
Department of Applied Chemistry, Tokai University
-
Nakagawa Koji
Department of Biochemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Nakamura Kazufumi
Department of Applied Chemistry, Faculty of Science and Technology, Keio University
-
Nagase Satoshi
Department of Cardiology, Okayama University Graduate School of Medicine
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- OE-308 C-Terminal Endothelin-1 Precursor Fragment (CT-proET-1) Reflects Cardiac Dysfunction in Hemodialysis Patients with Cardiovascular Disease(OE52,Kidney/Renal Circulation/CKD 2 (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The
- OJ-208 Which Blood Pressure is the Most Powerful Predictor of Hypertensive Multiple Organ Damages?(Hypertension, clinical(03)(H),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-542 Cystatin C indicates diastoric dysfunction in patients without clinical cardiac dysfunction(Heart failure, clinical(12)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-340 International Comparison of Clinical Use of Inotrope and Vasodilator Therapy for Acute Decompensated Heart Failure(Heart failure, clinical(10)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-193 The Effect of Noninvasive Positive Pressure Ventilation on Treatment of Patients with Flash Pulmonary Edema Admitted to the Emergency Department(Heart failure, clinical(08)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japane
- PE-565 Plasma Endothelin-1 Concentration in Patients with Pulmonary Hypertension Treated with Bosentan(Pulmonary circulation(02)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Second Left Ventricular Aneurysm Newly Developed in a Patient With Untreated Cardiac Sarcoidosis
- SCN5A Mutation Is Associated With Early and Frequent Recurrence of Ventricular Fibrillation in Patients With Brugada Syndrome
- Different Characteristics of Peripartum Cardiomyopathy Between Patients Complicated With and Without Hypertensive Disorders : Results From the Japanese Nationwide Survey of Peripartum Cardiomyopathy
- Bland-White-Garland syndrome
- Evaluation of left ventricular rotation by two-dimensional speckle tracking method and real-time three-dimensional echocardiography : comparison with MRI tagging method
- Gender Differences in Age-Related Changes in Left and Right Ventricular Geometries and Functions : Echocardiography of a Healthy Subject Group
- Guidelines for Indication and Management of Pregnancy and Delivery in Women With Heart Disease (JCS 2010) : Digest Version
- Normal Values of Real-Time 3-Dimensional Echocardiographic Parameters in a Healthy Japanese Population : The JAMP-3D Study
- Intermittent arm ischemia induces vasodilatation of the contralateral upper limb