Coronary Flow Reserve and Oxygen Metabolism of the Right Ventricle : SYMPOSIUM ON COR PULMONALE
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概要
- 論文の詳細を見る
The flow reserve of the right coronary artery (RCA) and myocardial oxygen extraction are important tractors in any investigation of the mechanisms of impaired right ventricular function. The present study induced brief coronary occlusions and examined the effect on right coronary blood flow in normal dogs, and the effect on myocardial oxygen metabolism in dogs with right ventricular hypertrophy (RVH). Right coronary flow reserve, represented by occlusion duration causing a half maximum dilatation (T1/2), was greater in the RCA than in the left anterior descending coronary artery of normal dogs; 11.3±2.3 sec vs 5.9±1.4 sec. Myocardial oxygen extraction ratio (EO_2) of the right ventricle (RV), 51.3±1.6%, was significantly (p<0.05) lower than the index of the left ventricle (LV), 60.6±1.0%, and the extraction of the RV increased significantly in association with an increase of myocardial oxygen demand. In dogs with RVH caused by chronic banding of the pulmonary artery, this dominant oxygen reserve was lost: the EO_2 of the hypertrophied RV was high compared with the EO_2 of the normal RV (57.3±3.4% vs 51.3±1.6%, p<0.05), and no further increase in EO_2 was observed in the hypertrophied RV in response to the elevation of the myocardial oxygen requirement. Oxygen usage per 100g of the RV for a certain level of overall RV work, rate-pressure product, was significantly (p<0.02) lower in the hypertrophied RV (0.00054 mlO_2/beat・mmHg) than in the normal RV (0.0012 mlO_2/beat-mmHg). These \findings suggest that the normal RV had the dominant reserve of oxygen supply through both the greater capacity of flow increment and ability to increase oxygen uptake from blood. This advantage was lost in the hypertrophied RV, but improved oxygen efficacy to overall RV mechanical work would contribute to maintain the normal function in the hypertrophied RV.
- 社団法人日本循環器学会の論文
- 1989-10-20
著者
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Watanabe Hirofumi
The First Depertment Of Internal Medicine Okayama University Medical School
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Hina Kazuyoshi
Cardiovascular Medicine The Sakakibara Heart Institute Of Okayama
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SAITO DAIJI
The First Depertment of Internal Medicine, Okayama University Medical School
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YAMADA NOBUYUKI
The First Depertment of Internal Medicine, Okayama University Medical School
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KUSACHI SHOZOU
The First Depertment of Internal Medicine, Okayama University Medical School
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TANI HIDEKI
The First Depertment of Internal Medicine, Okayama University Medical School
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SHIMIZU AKINORI
The First Depertment of Internal Medicine, Okayama University Medical School
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HINA KAZUMASA
The First Depertment of Internal Medicine, Okayama University Medical School
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UEEDA MASAYUKI
The First Depertment of Internal Medicine, Okayama University Medical School
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MIMA TSUTOMU
The First Depertment of Internal Medicine, Okayama University Medical School
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TSUJI TAKAO
The First Depertment of Internal Medicine, Okayama University Medical School
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HARAOKA SHOICHI
Clinical Laboratory of Medicine, Okayama University Medical School
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Saito Daiji
The Department Of Cardiovascular Medicine Okayama University Medical School
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Saito Daiji
Iwakuni National Hospital
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Saito Daiji
The First Department Of Internal Medicine Okayama University Medical School
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Saito Daiji
The Department Of Laboratory Medicine
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Tani Hideki
Department Of Cardiorenal Cerebrovasucluar Medicine
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Mima Tsutomu
The Center Laboratories Of Okayama University Medical School
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Hina Kazuyoshi
The First Department Of Internal Medicine Okayama University Medical School
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Ueeda Masayuki
The First Depertment Of Internal Medicine Okayama University Medical School
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Shimizu Akinori
Cardiovascular Center Sakakibara Hospital
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Yonahara Nobuhiko
The 1st Department Of Internal Medicine Okayama University Medical School
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Saito Daiji
Department Of Cardiovascular Medicine Okayama University
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Haraoka Shoichi
The Central Laboratory of Okayama University Medical School
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Yamada Nobuyuki
The Department Of Cardiology Fukuyama Municipal Hospital
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Haraoka Shoichi
The Department Of Cardiovascular Medicine Okayama University Medical School
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Hirano Kazuhiro
The 1st Department of lnternal Medicine Okayama University Medical School
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Haraoka Shoichi
1st Dept. Of Intern. Med. Okayama Univ. Med. School
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Haraoka Shoichi
Center Labor. Okayama Univ. School Of Med.
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Tsuji Takao
The First Depertment Of Internal Medicine Okayama University Medical School
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Tsuji Takao
The First Department Of Internal Medicine
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Saito Daiji
1st Dept. Intern. Med. Okayama Univ. School Of Med.
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Takinami Hiroyuki
Department Of Cardiorenal Cerebrovasucluar Medicine
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Hina Kazumasa
Cardiovascular Medicine The Sakakibara Heart Institute Of Okayama
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Yamada Nobuyuki
The First Department Of Internal Medicine Okayama University Medical School
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Saitio Daiji
岡山大学 循環器内科
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Tani H
Second Department Of Internal Medicine Kagawa University
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Saito Daiji
First Department Of Internal Medicine Okayama University Medical School
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Haraoka Shoichi
Dept. Of Intern. Med. Okayama Univ. Med. School
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Tani H
Department Of Cardiorenal Cerebrovasucluar Medicine
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Yonahara Nobuhiko
1st Dept Of Intern. Med. Okayama Univ. School Of Med.:central Laboratory Okayama Univ. School Of Med
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Shimizu Akinori
Cardiovasucular Center Sakakibara Hospital
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Hina Kazumasa
First Department Of Internal Medicine Okayama University Medical School
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Takinami Hiroyuki
Department Of Cardiorenal And Cerebrovascular Medicine Kagawa University
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Yonahara Nobuhiko
1st Dept Of Intern. Med. Okayama Univ. School Of Med.:central Laboratory Okayama Univ. School Of Med.:sakakibara Jyuzen Hospital
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