EFFECT OF PACEMAKER SITES ON CONTACTILE FORCES OF THE LOCAL MYOCARDIUM AND BLOOD FLOW IN THE MAJOR BRANCHES OF THE LEFT CORONARY ARTERY IN ANESTHETIZED OPEN-CHEST DOGS
スポンサーリンク
概要
- 論文の詳細を見る
Decreased cardiac performance during ventricular tachycardia or ventricular pacing has been ascribed to the lack of synchrony due to altered ventricular contraction. However, the direct effect of the pacemaking site on blood flow in the major coronary arterial branches and on regional contractile forces has not been adequately examined. In this investigation, twelve dogs were used to assess coronary flow in the left anterior descending (LAD) and circumflex coronary arteries (LCx) and the regional myocardial function in response to ectopic electrical pacing. The sites were the outflow tract of the right ventricle (RV pacing), the anterior left ventricular wall suppled by the LAD (LAD pacing), and the lateral wall perfused by the LCx (LCx pacing). Strain gauge arches were transmurally fixed to myocardial segments of the anterior and lateral walls of the left ventricle. The mechanical forces generated were measured while simultaneously recording blood flow in the LAD and LCx. RV pacing diminished developed-tension similarly in both areas. LAD flow was further decreased during anterior pacing as was the developed-tension in the LAD supplied area. A similar relationship was observed between LCx flow and developed-tension in the LCx area during lateral pacing. Compared to RV pacing, anterior pacing did not affect LCx flow and local myocardial force in the lateral wall of the left ventricle, and lateral pacing did not cause further changes in LAD flow and anterior myocardial function. The decrements in blood flow were closely related to decreased myocardial function (p<0.01). These findings indicate that ventricular pacing decreases ventricular performance with attenuated regional myocardial function at the pacing area, in addition to causing altered ventricular contraction sequence.
- 1984-04-20
著者
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SAITO DAIJI
The First Depertment of Internal Medicine, Okayama University Medical School
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TANI HIDEKI
The First Depertment of Internal Medicine, Okayama University Medical School
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Haraoka Shoichi
The First Department of Internal Medicine, Okayama University Medical School
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Nagashima Hideo
The First Department of Internal Medicine, Okayama University Medical School
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Saito Daiji
Iwakuni National Hospital
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Saito Daiji
The First Department Of Internal Medicine Okayama University Medical School
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Saito Daiji
The Department Of Laboratory Medicine
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Tani Hideki
Department Of Cardiorenal Cerebrovasucluar Medicine
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Saito Daiji
Department Of Cardiovascular Medicine Okayama University
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Haraoka Shoichi
The Central Laboratory of Okayama University Medical School
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TAKEDA KOU
The First Department of Internal Medicine
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HYODO TAZUO
The First Department of Internal Medicine
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ABE YUKIHIRO
The First Department of Internal Medicine
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UCHIDA TOSHIAKI
The First Department of Internal Medicine
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NAGAHANA Haruki
The First Department of Internal Medicine Okayama University Medical School
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Haraoka Shoichi
The Department Of Cardiovascular Medicine Okayama University Medical School
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Haraoka Shoichi
The First Department Of Internal Medicine Okayama University Medical School
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Nagashima Hideo
The First Department Of Internal Medicine Okayama University Medical School
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Takeda Kou
The First Department Of Internal Medicine Okayama University Medical School
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Hyodo Tatsuo
The First Department Of Internal Medicine
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Abe Yukihiro
First Department Of Internal Medicine Okayama University Medical School
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Saito Daiji
1st Dept. Intern. Med. Okayama Univ. School Of Med.
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Takinami Hiroyuki
Department Of Cardiorenal Cerebrovasucluar Medicine
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Nagashima Hideo
The Ist Dept. Of Intern. Med. Okayama Univ. Med. School
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NAGAHARA HARUKI
The First Department of Internal Medicine, Okayama University Medical School
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Saitio Daiji
岡山大学 循環器内科
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Tani H
Second Department Of Internal Medicine Kagawa University
-
Saito Daiji
First Department Of Internal Medicine Okayama University Medical School
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Tani H
Department Of Cardiorenal Cerebrovasucluar Medicine
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Nagahana H
First Department Of Internal Medicine Okayama University Medical School
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