Comparative Effects of Heart Rate and Aortic Blood Pressure on MVO2 in the Anesthetized Open-Chest Dog

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Comparative effects of heart rate and aortic blood pressure on myocardial oxygen consumption (MVO2) were studied in anesthetized openchest dogs. The left coronary artery was perfused through the external shunt with blood from the left common carotid artery. Heart rate was changed with the left atrial pacing and the constriction of the descending thoracic aorta was utilized to elevate the proximal aortic blood pressure (BP). The left ventricular enddiastolic pressure was insignificantly changed with the atrial pacing and with the aortic constriction. With the constant BP (100±5mmHg), an unit increase in heart rate per minute augmented MVO2, by 0.027ml/min/100Gm of left ventricular muscle, while one mmHg elevation of BP caused 0.15ml increment in MVO2 per minute per 100Gm of left ventricular muscle under the conscant heart rate (115±5beats/min). Therefore an unit change in BP caused five-to six-fold greater increase in MVO2 compared with that in heart rate, indicating extremely important roles of BP in MVO2.
International Heart Journal刊行会の論文