Laminin .ALPHA.1, .ALPHA.2, .ALPHA.4 and .BETA.1 Chain mRNA Expression in Mouse Embryonic, Neonatal, and Adult Hearts.

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概要

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• We examined the relative expression of laminin α1, α2, α4 and β1 chain genes in the heart of embryonic, neonatal and adult BALb/c mice. The reverse transcriptase-polymerase chain reaction was employed to determine the mRNA expression of these chains because of the relatively small amount of RNA extracted from rat embryonic hearts. Glyceraldehyde 3-phosphate dehydrogenase and β-actin were used as internal controls. Among the hearts examfined, a relatively high expression of laminin α1 chain was observed in the embryonic hearts, while its expression was very weak in the neonatal and negligible in the adult hearts. Conversely, expression of laminin α2 chain was virtually not observed in the embryonic hearts, but this chain was expressed weakly in the neonatal and substantially in the adult hearts. Similar to laminin α1, laminin α4 was expressed in the embryonic hearts, while its expression was relatively weak in the neonatal and adult hearts. Laminin β1 was expressed in the hearts of mice at all stages examined. These results demonstrate that the laminin chain gene expression changes in the different developmental stages of the hearts of BALb/c mice.

• International Heart Journal刊行会の論文

著者

• NINOMIYA Yoshifumi

  Department of Molecular Biology and Biochemistry, Okayama University Medical School

• Kusachi Shozo

  First Department Of Internal Medicine Okayama University Medical School

• Kondo Jun

  First Department Of Internal Medicine Okayama University Medical School

• MURAKAMI Masahiro

  First Department of Internal Medicine

• DOI Masayuki

  First Department of Internal Medicine

• Ninomiya Yoshifumi

  Department Of Molecular Biology And Biocemistry Okayama University Medical School

• Tsuji Takao

  First Department Of Internal Medicine Okayama University Medical School

• HIROHATA Satoshi

  First Department of Internal Medicine Okayama University Medical School

• SANO Issei

  First Department of Internal Medicine Okayama University Medical School

• DOI Masayuki

  First Department of Internal Medicine Okayama University Medical School

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