Brain Link Proteins : New Insights for Hyaluronan-Binding Proteoglycans in Brain(<Special Issue>Roles of Extracellular Matrix in the Development and Regeneration of Nervous Systems)

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概要

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• Link protein is originally characterized as an abundant extracellular matrix protein in cartilage and named Crtl1. It can stabilize aggregates of aggrecan and hyaluronan, giving cartilage its tensile strength. Similarly to the cartilage matrix, a high content of hyaluronan matrix has also been recognized in the brain matrix. Subsequently, several hyaluronan binding chondroitin sulphate proteoglycans, called lecticans, have been identified as the abundant extracellular matrix molecules in the developing and/or adult brain. Other than Crtl1, brain-specific link protein gene, Brail, was cloned recently. The two link proteins (LPs), old and new, are differentially expressed and seemed to be coordinately expressed with lecticans in the brain. In this review, we will focus on these brain link proteins that may play crucial roles in hyaluronan matrix.

• 日本結合組織学会の論文
• 2003-03-25

著者

• NINOMIYA Yoshifumi

  Department of Molecular Biology and Biochemistry, Okayama University Medical School

• OOHASHI Toshitaka

  Department of Molecular Biology and Biochemistry, Okayama University Medical School

• Ninomiya Y

  Department Of Molecular Biology And Biochemistry Okayama University Graduate School Of Medicine Dent

• Ninomiya Yoshifumi

  Departments Of Molecular Biology And Biochemistry Okayama University Graduate School Of Medicine And

• Ninomiya Yoshifumi

  Department Of Molecular Biology And Biocemistry Okayama University Medical School

• Okigaki T

  Division Of Social Welfare Faculty Of Social Welfare Kinki Welfare University

• Oohashi Toshitaka

  Departments Of Molecular Biology And Biochemistry Okayama University Graduate School Of Medicine And

• Oohashi Toshitaka

  Department Of Molecular Biology And Biochemistry Okayama University Medical School

• Oohashi Toshitaka

  Department Of Molecular Biology And Biochemistry Okayama University Graduate School Of Medicine Dent

• Oohashi Toshitaka

  Department Of Molecular Biology And Biochemistry Okayama University Graduate School Of Medicine And

• Oohashi T

  Department Of Molecular Biology And Biochemistry Okayama University Graduate School Of Medicine Dent

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