Active synthesis of collagen by albumin-producing liver parenhymal cell clones in culture.

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概要

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• Two lines of albumin-producing rat liver parenchymal cell clones (BB and BC) have been shown to synthesize collagen at a level of 1-2% of total proteins produced which was two to nine times higher than those by the fibroblastic cells (L-929 and RLG-1). Type analysis of the collagen by carboxymethylcellulose chromatography has shown that the former two cell lines synthesized type I collagen, [α1(I)]2α2, type X, composed of α1 chains and type Y similar to type III collagen, while a transformed liver cell line (M) did the former two collagen types.

• 日本学士院の論文

著者

• Ninomiya Yoshifumi

  Department Of Molecular Biology And Biocemistry Okayama University Medical School

• Hata Ryu-ichiro

  Department Of Biochemistry And Molecular Biology Kanagawa Dental College

• Nagai Yutaka

  Department Of Obstetrics And Gynecology Faculty Of Medicine University Of The Ryukyus

• TSUKADA Yutaka

  Department of Biochemistry, Hokkaido University School of Medicine

• NINOMIYA Yoshifumi

  Department of Tissue Physiology, Medical Research Institute, Tokyo Medical and Dental University

• SAKAKIBARA Kooko

  Department of Carcinogenesis and Cancer Susceptibility, Institute of Medical Science, University of Tokyo

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