Collagen production by Cultured Human Retinal Pigment Epithelial Cells
スポンサーリンク
概要
- 論文の詳細を見る
We investigated extracellular matrix produced by human retinal pigment epithelial cells (RPE) in vitro using electron microscopy and enzyme linked immunosorbent assay (ELISA). The thickness of the matrix under the cell layer was about 30 μm after 360 days of culture. It consisted mainly of fibrous and granular components. Type IV and V collagen were detected but type I and III were not detected by ELISA. It appeared that REE can secrete type IV and V collagen and form a thick membrane which may cause proliferative vitreoretinopathy (PVR) by contraction. Control of RPE proliferation and secretion of extracellular matrix is indispensable for prevention of PVR.
- 東海大学の論文
著者
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MINAMOTO TOSHINARI
Department of Surgical Oncology, Cancer Research Institute, Kanazawa University
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TANAKA Yasuhiko
Department of Cardiology, Shizuoka Children's Hospital
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ISHIKAWA Hiroshi
Department of Radiology, Niigata University School of Medicine
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OBAZAWA Hajime
Eye Research Institute of Cataract Foundation
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Kigasawa Kazuteru
Department Of Ophthalmology School Of Medicine Tokai University
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Obazawa H
Tokai Univ. School Of Medicine
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Obazawa Hajime
Department Of Ophthalmology School Of Medicine Tokai University
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NAGAI Yutaka
Departments of Obstetrics and Gynecology, University of the Ryukyus School of Medicine
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Tanaka Yasuhiko
Department Of Ophthalmology School Of Medicine Keio University
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Minamoto Toshinari
Department Of Tissue Physiology Medical Research Institute Tokyo Medical And Dental University
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Minamoto Toshinari
Department Of Surgical Oncology Cancer Research Institute Kanazawa University
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Ishikawa Hiroshi
Department Of Public Health Mie University School Of Medicine
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Tanaka Y
Department Of Ophthalmology School Of Medicine Keio University
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Nagai Yutaka
Department Of Obstetrics And Gynecology Faculty Of Medicine University Of The Ryukyus
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Nagai Yutaka
Department Of Tissue Physiology Medical Research Institute Tokyo Medical And Dental University
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Tanaka Yasuhiko
Department Of Applied Chemistry Graduate School Of Engineering Kyushu University
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Ishikawa Hiroshi
Department Of Anatomy Jikei University School Of Medicine
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Ishikawa Hiroshi
Department Of Ophthalmology School Of Medicine Tokai University
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Ishikawa Hiroshi
Department Of Anatomy Jikai University School Of Medicine
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