漿膜中皮細胞下の基底膜コラーゲンはα1鎖, α2鎖, α5鎖, and α6鎖で構成される

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概要

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• Serous membrane (SM) covers inner surface of abdominal, thoracic and pericardial cavities, aswell as outer surface of organs inside the cavities. It consists of surface mesothelial cells andloose connective tissue. Between them, a thim layer of basement membrane (BM) is located. Type IVcollagen is major constituent of BM, and consists of 6 different a(IV) chains, a1(IV) through a6(IV).Chain-specific functions are assumed by a chain-specific manner of localization. The a(IV) chaincomposition of skin, covering outer surface of the body, is demonstrated to have a1(IV), a2(IV), a5(IV),and a6(IV) chains, whereas that of SM, covering inner surface of the body, is yet to be analyzed. Abdominal wall, small intestine, thoracic wall, lung, pericardium and epicardium of humanmaterials were used in this study. Chain-specific monoclonal antibodies (mAbs) used were H11(for a1), H22 (for a2), H31 (fo a3), H43 (for a4), H53 (for a5) and H63 (for a6). Fresh frozen sectionswere stained with indirect immunofluorescence staining using the mAbs. Four out of six a(IV) chains, a1, a2, a5 and a6, were demonstrated in BM beneath themesothelial cells of all types of SMs, whereas only capillary BM consisted of a1 and a2. Besides,epicardial SM expressed a3 and a4 moderately as extra components. The a(IV) chain composition was same as those of epidermal skin BM. Therefore, these a(IV)chains are designated to be essential for BM covering inside and outside of the body.

• 近畿医療福祉大学の論文
• 2000-12-12

著者

• 二宮 善文

  岡山大学大学院 医歯薬学総合研究科 分子医化学

• 二宮 善文

  岡山大学 第2解剖

• SADO Yoshikazu

  Division of Immunology, Shigei Medical Research Institute

• NINOMIYA Yoshifumi

  Department of Molecular Biology and Biochemistry, Okayama University Medical School

• Sado Y

  Shigei Medical Research Institute

• Sado Yoshikazu

  Division Of Immunology Shigei Medical Research Institute

• Sado Yoshikazu

  Divisions Of Immunology And Ultrastructure Research Shigei Medical Research Institute

• NAITO Ichiro

  Divisions of Ultrastructural Biology and Immunology, Shigei Medical Research Institute

• Ninomiya Y

  Department Of Molecular Biology And Biochemistry Okayama University Graduate School Of Medicine Dent

• Ninomiya Yoshifumi

  Department Of Molecular Biology And Biocemistry Okayama University Medical School

• Okigaki T

  Division Of Social Welfare Faculty Of Social Welfare Kinki Welfare University

• Takahashi Chieko

  Shigei Medical Research Institute

• TAKAHASHI Chieko

  Divisions of Ultrastructural Biology, Shigei Medical Research Institute

• Oohashi Toshitaka

  Department Of Molecular Biology And Biochemistry Okayama University Medical School

• Oohashi Toshitaka

  Department Of Molecular Biology And Biochemistry Okayama University Graduate School Of Medicine Dent

• Naito Ichiro

  Department Of Human Morphology Okayama University Graduate School Of Medicine Dentistry And Pharmace

• Ohmori Hiroyuki

  Shigei Med. Res. Inst. Okayama Univ. Grad. Sch. Med. And Dent.

• Naito Ichiro

  Division Of Immunology Shigei Medical Research Institute

• Matsubara Tatsuya

  Division of Internal Medicine, Shigei Medical Research Hospital

• Ohmori Hiroyuki

  Division of Internal Medicine, Shigei Medical Research Hospital

• Okigaki Tohru

  Department of Social Welfare, School of Social Welfare, Kinki Welfare University

• Ninomiya Yoshifumi

  Department Of Molecular Biology And Biochemistry Okayama University Graduate School Of Medicine Dent

• Sado Y

  Division Of Immunology Shigei Medical Research Institute

• Oohashi T

  Department Of Molecular Biology And Biochemistry Okayama University Graduate School Of Medicine Dent

• Naito Ichiro

  Department Of Human Morphology Okayama University Graduate School Of Medicine Dentistry And Pharmace

• Matsubara Tatsuya

  Division Of Internal Medicine Shigei Medical Research Hospital

• Naito I

  Department Of Human Morphology Okayama University Graduate School Of Medicine Dentistry And Pharmace

• 内藤 一郎

  Division of Ultrastructual Biology, Shigei Medical Research Institute

• 松原 龍也

  Division of Internal Medicine, Shigei Medical Research Hospital

• 高橋 千恵子

  Division of Ultrastructual Biology, Shigei Medical Research Institute

• Hiroyuki Ohmori

  Division of Internal Medicine, Shigei Medical Research Hospital

• Yoshikazu Sado

  Division of Immunology, Shigei Medical Research Institute

• Yoshifumi Ninomiya

  Department of Molecular Biology and Biochemistry,Okayama University School of Medicine

• Tohru Okigaki

  Department of Social Welfare, School of Social Welfare, Kinki Welfare University

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