The Release of Collagenase Inhibitors from Procollagen Additional Peptides by Pepsin Treatment

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概要

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• Procollagen, a precursor of collagen, was isolated from cultured medium of matrix-free cells from tendon of 16-day-old chick embryos. Tendon procollagen was shown, by limited proteolysis with pepsin followed by gel chromatography, to possess collagenase inhibiting capacity at its N- and/or C-terminal additional peptide portion(s). The results suggest that collagenase inhibiting activity is manifested upon conversion of procollagen to collagen to protect it from proteolysis with collagenase.

• 日本学士院の論文

著者

• Ninomiya Yoshifumi

  Department Of Molecular Biology And Biocemistry Okayama University Medical School

• Nagai Yutaka

  Department Of Obstetrics And Gynecology Faculty Of Medicine University Of The Ryukyus

• Shinkai Hiroshi

  Department Of Clinical Biology Of Extracellular Matrix Graduate School Of Medicine Chiba University

• SHINKAI Hiroshi

  Department of Dermatology, Osaka University School of Medicine

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