基底膜コラーゲンのフラグメントによる血管新生阻害(<特集>コラーゲン研究)

概要

論文の詳細を見る
Basement membrane is a complex network of various proteins, proteoglycans, and other macromolecules that are interconnected in a mesh-like structure that provides mechanical support for cells and tissues. In the last three decades, considerable research has been conducted concerning that tumor growth and metastasis require angiogenesis. Therefore, endogenous angiogenesis inhibitors are promising candidates for cancer therapy with low toxicity. These include endostatin, which was originally purified from the conditioned media of a murine hemangioendothelioma and identified as a proteolytically cleaved fragment of type XVIII collagen. This review describes the characteristic features and functions of the carboxyterminal NC 1 domains of collagens type IV, VIII, XV and XVIII, that provide inhibitory activity of angiogenesis.
日本結合組織学会の論文
2002-06-25