Peroxidase-Like Catalytic Activity of Aqueous- and Immobilized-Mn^<3+>-octabromo-porphyrins on Ion-Exchange Resin Supplied as Mimetic of Horseradish Peroxidase
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概要
- 論文の詳細を見る
In order to explore the capability of metal porphyrins as an alternative of horseradish peroxidase (HRP), HRP-like activity of three manganese-porphyrins (Mn-Ps) and three Mn-octabromo-porphyrins (Mn-OBPs) was examined in both aqueous and immobilized states. It was found that Mn^<3+>-octabro-motetrakis (1-methyl-pyridinium-4yl) porphine (Mn-OBTMPyP) has an activity of at least 90% of HRP in an aqueous solution. Mn-OBTMPyP exhibited a catalytic activity even in the presence of hydrogen peroxide without suicide reaction. In addition, Mn-OBTMPyP was revealed to function as an alternative to HRP in the quantitative determination of serum uric acid. These results are of great interest because they indicate that metal-octabromo-porphyrins possibly include promising candidates of artificial enzyme capable of substituting for HRP.
- 公益社団法人日本薬学会の論文
- 2008-09-01
著者
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Kitamura Youji
Department Of Pharmaceutical Sciences Graduate School Of Medicine And Dentistry And Pharmaceutical S
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Saito Yutaka
Department Of Pharmaceutical Sciences Graduate School Of Medicine And Dentistry And Pharmaceutical S
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Saito Y
Department Of Pharmaceutical Sciences Graduate School Of Medicine And Dentistry And Pharmaceutical S
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Saito M
Tsukuba Research Drug Safety Research Laboratories Eisai Co. Ltd.
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Saito Mariko
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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MORI Katsuya
Department of Pharmaceutical Sciences, Graduate School of Medicine and Dentistry and Pharmaceutical
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YAMAMOTO Makiko
Department of Pharmaceutical Chemistry, Graduate School of Natural Science and Technology, Okayama U
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NOZAKI Akira
Department of Pharmaceutical Chemistry, Graduate School of Natural Science and Technology, Okayama U
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SAITO Madoka
Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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TSUKAMOTO Ikuko
Faculty of Medicine, Kagawa University
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MIFUNE Masaki
Department of Pharmaceutical Sciences, Graduate School of Medicine and Dentistry and Pharmaceutical
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Mifune Masaki
Department Of Pharmaceutical Sciences Graduate School Of Medicine And Dentistry And Pharmaceutical S
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Kuge Yuji
Department Of Patho-functional Bioanalysis Graduate School Of Pharmaceutical Sciences Kyoto Universi
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Mori Katsuya
Department Of Pharmaceutical Sciences Graduate School Of Medicine And Dentistry And Pharmaceutical S
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Nozaki Akira
Department Of Pharmaceutical Chemistry Graduate School Of Natural Science And Technology Okayama Uni
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Nozaki Akira
Department Of Biochemical Science And Technology Faculty Of Agriculture Kagoshima University
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Yamane M
Department Of Pharmaceutical Chemistry Graduate School Of Natural Science And Technology Okayama Uni
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Kitamura Youji
Department Of Patho-functional Bioanalysis Graduate School Of Pharmaceutical Sciences Kyoto Universi
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Tsukamoto Ikuko
Faculty Of Medicine Kagawa University
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Yamamoto Makiko
Department Of Food Science And Nutrition Nara Women's University
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Saito Yutaka
Department Of Endoscopy National Cancer Center Hospital
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Yamamoto Makiko
Department Of Biology Faculty Of Sciences Ochanomizu University
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Saito Madoka
Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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Saito Yutaka
Department of Pharmaceutical Sciences, Graduate School of Medicine and Dentistry and Pharmaceutical Sciences, Okayama University
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Mifune Masaki
Department of Pharmaceutical Sciences, Graduate School of Medicine and Dentistry and Pharmaceutical Sciences, Okayama University
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Saito Yutaka
Department of Chemistry, Nagaoka University of Technology
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