Brain Extraction of 4-(4-Chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]pyridinium Ion (HPP^+), a Neurotoxic Metabolite of Haloperidol : Studies Using [^3H]HPP^+
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概要
- 論文の詳細を見る
Tritium-labeled 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]pyridinium ion (HPP+) was synthesized enzymatically from [3H]haloperidol using rat liver microsomal preparations, and using prepared [3H]HPP+, the passage of HPP+ into the brain was investigated. Consequently, HPP+ showed a moderate brain uptake index, indicating that it is able to permeate the blood-brain barrier. Furthermore, HPP+ was detected in murine brains after being intravenously injected. These results suggested that HPP+, produced mainly in the liver, is taken up into the brain and induces damage to brain dopaminergic neurons.
- 社団法人 日本薬理学会の論文
- 2002-08-01
著者
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Saji H
Graduate School Of Pharmaceutical Sciences Kyoto University
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Saji Hideo
明治鍼灸大学
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Saji Hideo
Department Of Patho-functional Bioanalysis Graduate School Of Pharmaceutical Sciences Kyoto Universi
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Saji Hideo
茨城県立医療大学 放射線技術科学
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石井 靖
福井医科大学放射線部
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Magata Y
Photon Medical Research Center Hamamatsu University School Of Medicine:molecular Imaging Frontier Re
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Magata Yasuhiro
京都大学 医学研究科心臓血管外科学
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Magata Yasuhiro
浜松医科大学附属光量子医学研究センター
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Saji Hideo
Graduate School Of Pharmaceutical Sciences Kyoto University
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IIDA Yasuhiko
Department of Bioimaging Information Analysis, Gunma University Graduate School of Medicine
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Kiyono Yasushi
Department Of Radioisotope Laboratory Graduate School Of Medicine Kyoto University
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Kiyono Yasushi
京都大学 薬研究 病態機能分析
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Kiyono Yasushi
Faculty Of Pharmaceutical Sciences Kyoto University
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Magata Y
Laboratory Of Genome-bio Photonics Photon Medical Research Center Hamamatsu University School Of Med
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Yasuhiro Magata
Photon Medical Research Center Hamamatsu University School Of Medicine:molecular Imaging Frontier Re
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Kitamura Youji
Department Of Pharmaceutical Sciences Graduate School Of Medicine And Dentistry And Pharmaceutical S
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KAWASHIMA Hidekazu
Department of Patho-functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto Univer
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MAGATA Yasuhiro
Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto Univer
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ISHII Yasushi
Department of Radiology
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Ida Yuko
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences Universit
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Ishii Yasushi
Third Division Dept. Of Internal Medicine And Nuclear Medicine
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Iida Y
Department Of Bioimaging Medical Sciences Gunma University
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Iida Yasuhiko
Department Of Bioimaging Medical Sciences Gunma University
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Iida Yasuhiko
Department Of Radiopharmaceutical Chemistry Faculty Of Pharmaceutical Sciences Kyoto University
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Magata Yasuhiro
Department Of Nuclear Medicine Graduate School Of Medicine
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Sakahara H
Department Of Radiology Hamamatsu University School Of Medicine
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KAWASHIMA Hidekazu
Kyoto University Hospital
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Miyake Yoshinori
Department Of Radiology And Nuclear Medicine National Cardiovascular Center
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Kawashima Hideaki
Kyoto University Hospital
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Yamamuro Masaki
Department Of Diagnostic Imaging And Nuclear Medicine Kyoto University Graduate School Of Medicine
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Saji Hideo
Dep. Of Patho-functional Bioanalysis Graduate School Of Pharmaceutical Sciences Kyoto Univ.
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Kuge Yuji
Department Of Patho-functional Bioanalysis Graduate School Of Pharmaceutical Sciences Kyoto Universi
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Kitamura Youji
Department Of Patho-functional Bioanalysis Graduate School Of Pharmaceutical Sciences Kyoto Universi
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Sakahara H
Kyoto Univ. School Of Medicine
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Kawashima Hideaki
Graduate School Of Pharmaceutical Sciences Kyoto University
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Ishii Yasushi
Department Of Radiology Kyoto University School Of Medicine
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Saji Hideo
Department Of Cardiology Matsushita Memorial Hosipital
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Kawashima H
Kyoto Univ.
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Ishii Yasushi
Department Of Patho-functional Bioanalysis Graduate School Of Pharmaceutical Sciences Kyoto Universi
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Kawashima Hidekazu
Department Of Orthopaedic Surgery Kawasaki Municipal Kawasaki Hospital
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Kawashima Hidekazu
Department Of Nuclear Medicine And Diagnostic Imaging Graduate School Of Medicine Kyoto University
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