A Case with Silent Type of Pseudo-Acholinesterasemia

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概要

• 論文の詳細を見る

• One case of pseudo-acholinesterasemia was experienced in our hospital. The patient was a 54-year-old female with sigmoid colon cancer. A preoperative examination showed that her cholinesterase (ChE) level was 7 IU/L (normal range: 3,700-5,400 IU/L) although no abnormalities were found in other enzymes derived from the liver, total protein and albumin level in the serum. An investigation of eight family members over two generations revealed two cases of acholinesterasemia in addition to the patient. Immunological examination by Ouchterlony's method and isoenzyme analysis by polyacrylamide gel electrophoresis showed that ChE production was absent in this case, while dibucaine or fluoride number was normal among the family members. Based on these results, it was concluded that this patient belonged to the silent type of homozygote. A case of pseudo-acholinesterasemia, which is very rare in Japan, is described.

• 東海大学の論文

著者

• NIWA Masaharu

  Department of Clinical Pathology, School of Medicine Tokai University

• ANDO Yasuhiko

  Department of Blood Transfusion Service Center Tokai University Hospital

• KONDO HITOSHI

  Endoscopy Division, National Cancer Center Hospital

• Ito Kiichi

  Department Of Clinical Pathology School Of Medicine Tokai University

• Niwa Masaharu

  Department Of Clinical Pathology School Of Medicine Tokai University

• Ando Yasuhiko

  Department Of Clinical Pathology School Of Medicine Tokai University

• HARASAWA Shigeru

  Endoscopic Center, School of Medicine Tokai University

• Harasawa Shigeru

  Endoscopic Center School Of Medicine Tokai University

• MIYAMOTO Motoaki

  Central Cilinical Laboratory, Tokai University Hospital

• MASUKAWA Atuko

  Central Cilinical Laboratory, Tokai University Hospital

• OCHIAI Akiyo

  Central Cilinical Laboratory, Tokai University Hospital

• Kondo Hitoshi

  Endoscopic Center School Of Medicine Tokai University

• Ochiai Akiyo

  Central Cilinical Laboratory Tokai University Hospital

• Masukawa Atuko

  Central Cilinical Laboratory Tokai University Hospital

• Miyamoto Motoaki

  Central Cilinical Laboratory Tokai University Hospital

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